Abstract
B-cell lymphomas associated with HIV infection refer to a spectrum of lymphoid neoplasms whose incidence is increased in patients with HIV infection. These include AIDS-defining lymphomas, which confer a diagnosis of AIDS when they occur in an HIV-infected individual, as well as other lymphomas that are associated with HIV infection but do not confer an AIDS diagnosis. There is evidence that the immunologic milieu and the inflammatory state induced by HIV proteins are integral to the pathogenesis of these neoplasms. Effective combination antiretroviral therapy modulates these pathophysiologic features and effects changes in both tumor epidemiology and biology. Improved outcomes in patients with these tumors are based not only on improved prospects for HIV disease control but also due in part to more treatment-sensitive tumors that are more likely to develop when there is better preserved immune function. This chapter reviews the epidemiology and tumor pathology supporting this thesis. An additional and essential concept forwarded by this chapter is that AIDS-related lymphoma is no longer a clinically meaningful term, and the importance of modern lymphoid tumor classification is highlighted.
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Little, R.F., Pittaluga, S., Dunleavy, K. (2014). Presentation and Pathogenesis of B-Cell Lymphoid Cancers Associated with HIV Infection. In: Yarchoan, R. (eds) Cancers in People with HIV and AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0859-2_11
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DOI: https://doi.org/10.1007/978-1-4939-0859-2_11
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