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Bioreactors for Plant Biomass Production and Bioprocessing

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Genetically Engineered Plants as a Source of Vaccines Against Wide Spread Diseases

Abstract

In vitro propagation of plant biomass has played a key role in the production of plant-based vaccines, being the first US Department of Agriculture (USDA)-approved vaccine produced in cell suspension cultures. This chapter presents an analysis of the main characteristics and design aspects related to the distinct bioreactor types used for plant cell culture in the production of plant-based vaccines. Culture strategies for plant cells and bioprocess factors influencing yields or productivity in plant cultivation are also discussed with emphasis in biopharmaceutical production. Besides describing the main bioreactor types, the importance of operational conditions, design, scale-up, and bioprocess optimization is emphasized. Main parameters that would pave the way towards the successful commercialization of vaccines using plant cell bioprocesses are also discussed.

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Authors and Affiliations

  1. Laboratorio de Ingeniería de Biorreactores, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Av. Salvador Nava Martínez No. 6 Zona Universitaria, 78210, SLP, México

    Luz María Teresita Paz-Maldonado & José Enrique González-Ramírez

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  1. Luz María Teresita Paz-Maldonado
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  2. José Enrique González-Ramírez
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Correspondence to Luz María Teresita Paz-Maldonado .

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  1. Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico

    Sergio Rosales-Mendoza

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Paz-Maldonado, L., González-Ramírez, J. (2014). Bioreactors for Plant Biomass Production and Bioprocessing. In: Rosales-Mendoza, S. (eds) Genetically Engineered Plants as a Source of Vaccines Against Wide Spread Diseases. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0850-9_6

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