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Age-Specific Difference in Pulmonary Cellular Injury and Mitochondrial Damage

  • Katherine L. Tuggle
  • Michelle V. FanucchiEmail author
Chapter
  • 704 Downloads
Part of the Respiratory Medicine book series (RM, volume 15)

Abstract

The impact of lung-targeted toxicants on the respiratory system of developing and aging animals is not well defined, let alone the role that mitochondria may play in the cascade of factors involved in cellular injury. Environmentally induced pulmonary cell injury is often due to exposure to bioactivated toxicants or oxidant gases. The major defense mechanisms against these insults are the antioxidant and xenobiotic-metabolizing enzymes. The age-specific expression of these enzymes and their roles in protecting the lung from specific toxicants is discussed as well as the interrelationship with mitochondrial function. A review of the literature reveals evidence of the mitochondrial involvement in cellular injury during lung development and aging. Whether the alterations of mitochondria are critical early steps in lung injury or an outcome of a cascade of processes during lung development and aging is not clear at this time.

Keywords

Lung development Lung aging Mitochondria mtDNA Antioxidant Tobacco smoke Ozone Hyperoxia 

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of MedicalCystic Fibrosis FoundationBethesdaUSA
  2. 2.Department of Environmental Health SciencesUniversity of Alabama at BirminghamBirminghamUSA

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