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Mitochondrial Excitation-Energy Coupling in Airway Smooth Muscle

  • Niccole Schaible
  • Philippe Delmotte
  • Gary C. SieckEmail author
Chapter
Part of the Respiratory Medicine book series (RM, volume 15)

Abstract

Force generation and contraction of human airway smooth muscle (ASM) involves both an increase in intracellular Ca2 + and an increase in the demand for energy in the form of ATP. Excitation-contraction coupling (ECC) represents a cascade of events that connects the initiating signal, an elevation of cytosolic Ca2 +([Ca2 +]cyt), with the ensuing ATP-consuming mechanical work. Mitochondria play a vital role in this overall process by producing ATP. Moreover, mitochondria also possess the ability to sense [Ca2 +]cyt through a coupled increase in mitochondrial Ca2 +([Ca2 +]mito). In fact, an increase in [Ca2 +]mito leads to an increase in ATP production. Thus, the linkage between [Ca2 +]cyt and [Ca2 +]mito may reflect an “excitation-energy coupling” in ASM that mirrors the energy demand that results from excitation-contraction coupling. The result, in ASM, is the maintenance of an energy supply despite transient and/or sustained energetic demands – an energy homeostasis.

Keywords

Excitation-contraction coupling Metabolism Ca2+ signaling Homeostasis Energetics 

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Niccole Schaible
    • 1
  • Philippe Delmotte
    • 1
  • Gary C. Sieck
    • 1
    Email author
  1. 1.Department of Physiology and Biomedical EngineeringMayo Clinic College of MedicineRochesterUSA

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