Skip to main content
SpringerLink
Log in

Fertility Control in Wildlife: Review of Current Status, Including Novel and Future Technologies

  • Chapter
  • First Online:
Book cover Reproductive Sciences in Animal Conservation

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 753))

Abstract

Overpopulation of selected groups of animals is widely recognised as an issue that can have adverse effects on several current global problems, such as animal and human health, conservation and environmental changes. This review will, therefore, focus on recent novel contraception together with future technologies that may provide additional contraceptive methods.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Alving CR, Koulchin V, Glenn GM, Rao M. Liposomes as carriers of peptide antigens – induction of antibodies and cytotoxic T-lymphocytes to conjugated and unconjugated peptides. Immunol Rev. 1995;145:5–31.

    CAS  PubMed  Google Scholar 

  • Arlt SP, Spankowsky S, Heuwieser W. Follicular cysts and prolonged oestrus in a female dog after administration of a deslorelin implant. N Z Vet J. 2011;59:87–91.

    CAS  PubMed  Google Scholar 

  • Asa C, Porton I, Baker A, Plotka E. Contraception as a management tool for controlling surplus animals. In: Kleiman M, Allen M, Thompson K, Lumpkin S, editors. Wild mammals in captivity. Chicago, IL: University of Chicago Press; 1996.

    Google Scholar 

  • Ballesteros C, Carrasco-Garcia R, Vicente J, Carrasco J, Lasagna A, de la Fuente J, et al. Selective piglet feeders improve age-related bait specificity and uptake rate in overabundant Eurasian wild boar populations. Wildl Res. 2009a;36:203–12.

    Google Scholar 

  • Ballesteros C, Garrido JM, Vicente J, Romero B, Galindo RC, Minguijon E, et al. First data on Eurasian wild boar response to oral immunization with BCG and challenge with a Mycobacterium bovis field strain. Vaccine. 2009b;27:6662–8.

    CAS  PubMed  Google Scholar 

  • Ballesteros C, Gortazar C, Canales M, Vicente J, Lasagna A, Gamarra JA, et al. Evaluation of baits for oral vaccination of European wild boar piglets. Res Vet Sci. 2009c;86:388–93.

    PubMed  Google Scholar 

  • Ballesteros C, Vicente J, Morriss G, Jockney I, Rodriguez O, Gortazar C, et al. Acceptance and palatability for domestic and wildlife hosts of baits designed to deliver a tuberculosis vaccine to wild boar piglets. Prev Vet Med. 2011;98:198–203.

    PubMed  Google Scholar 

  • Baskran N, Desai AA. Ranging behavior of the Asian elephant (Elephas maximus) in the Nilgiri biosphere reserve, South India. Gajah. 1996;15:41–57.

    Google Scholar 

  • Bergman D, Bender S, Wenning K, Slate D, Rupprecht C, Heuser C, et al. Bait acceptability for delivery of oral rabies vaccine to free-ranging dogs on the Navajo and Hopi Nations. Dev Biol. 2008;131:145–50.

    CAS  Google Scholar 

  • Bertschinger HJ, Trigg TE, Jochle W, Human A. Induction of contraception in some African wild carnivores by downregulation of LH and FSH secretion using the GnRH analogue deslorelin. Reproduction. 2002;41–52.

    Google Scholar 

  • Bertschinger HJ, Jago M, Nothling JO, Human A. Repeated use of the GnRH analogue deslorelin to down-regulate reproduction in male cheetahs (Acinonyx jubatus). Theriogenology. 2006;66:1762–7.

    CAS  PubMed  Google Scholar 

  • Bertschinger, H. J., A. Delsink, J.J. van Altena, D. Grobler, J.F. Kirkpatrick, M. Bates & Burke, T. Effects of porcine zona pellucida immunocontraception on annual calving percentages of six discrete African Elephant populations. 6th International Conference on Fertility Control for Wildlife. York, UK. 2007.

    Google Scholar 

  • Blackburn TM, Cassey P, Duncan RP, Evans KL, Gaston KJ. Avian extinction and mammalian introductions on oceanic islands. Science. 2004;305:1955–8.

    CAS  PubMed  Google Scholar 

  • Buddle BM, Wedlock DN, Denis M, Vordermeier HM, Hewinson RG. Update on vaccination of cattle and wildlife populations against tuberculosis. Vet Microbiol. 2011;151:14–22.

    PubMed  Google Scholar 

  • Budke CM, Slater MR. Utilization of matrix population models to assess a 3-year single treatment nonsurgical contraception program versus surgical sterilization in feral cat populations. J Appl Anim Welf Sci. 2009;12:277–92.

    CAS  PubMed  Google Scholar 

  • Chen Z, He W, Wu Y, Yan P, He H, Zhang J, et al. A highly specific antibody response after protein prime-peptide boost immunization with Eppin/B-cell epitope in mice. Hum Vaccines. 2011;7:849–55.

    CAS  Google Scholar 

  • Choudhury S, Kakkar V, Suman P, Chakrabarti K, Vrati S, Gupta SK. Immunogenicity of zona pellucida glycoprotein-3 and spermatozoa YLP12 peptides presented on Johnson grass mosaic virus-like particles. Vaccine. 2009;27:2948–53.

    CAS  PubMed  Google Scholar 

  • Corner LA, Buddle BM, Pfeiffer DU, Morris RS. Aerosol vaccination of the brushtail possum (Trichosurus vulpecula) with bacille Calmette-Guerin: the duration of protection. Vet Microbiol. 2001;81:181–91.

    CAS  PubMed  Google Scholar 

  • Corner LA, Costello E, Lesellier S, O'Meara D, Gormley E. Vaccination of European badgers (Meles meles) with BCG by the subcutaneous and mucosal routes induces protective immunity against endobronchial challenge with Mycobacterium bovis. Tuberculosis (Edinb). 2008;88:601–9.

    Google Scholar 

  • Corner LAL, Costello E, O'Meara D, Lesellier S, Aldwell FE, Singh M, et al. Oral vaccination of badgers (Meles meles) with BCG and protective immunity against endobronchial challenge with Mycobacterium bovis. Vaccine. 2010;28:6265–72.

    CAS  PubMed  Google Scholar 

  • Cross ML, Henderson RJ, Lambeth MR, Buddle BM, Aldwell FE. Lipid-formulated bcg as an oral-bait vaccine for tuberculosis: vaccine stability, efficacy, and palatability to brushtail possums (Trichosurus vulpecula) in New Zealand. J Wildl Dis. 2009;45:754–65.

    PubMed  Google Scholar 

  • Curtis PD, Pooler RL, Richmond ME, Miller LA, Mattfeld GF, Quimby FW. Comparative effects of GnRH and porcine zona pellucida (PZP) immunocontraceptive vaccines for controlling reproduction in white-tailed deer (Odocoileus virginianus). Reproduction. 2002;131–141.

    Google Scholar 

  • Dell'Omo G, Palmery M. Fertility control in vertebrate pest species. Contraception. 2002;65:273–5.

    PubMed  Google Scholar 

  • Delsink AK, van Altena JJ, Kirkpatrick J, Grobler D, Fayrer-Hosken RA. Field applications of immunocontraception in African elephants (Loxodonta africana). Reproduction. 2002; 117–124.

    Google Scholar 

  • Delsink AK, van Altena JJ, Grobler D, Bertschinger HJ, Kirkpatrick JF, Slotow R. Implementing immunocontraception in free-ranging African elephants at makalali conservancy. J S Afr Vet Assoc. 2007;78:25–30.

    CAS  PubMed  Google Scholar 

  • Delves PJ, Roitt IM. Vaccines for the control of reproduction—status in mammals, and aspects of comparative interest. Dev Biol. 2005;121:265–73.

    CAS  Google Scholar 

  • Druce HC, Mackey RL, Slotow R. How Immunocontraception Can Contribute to Elephant Management in Small. Enclosed Reserves: Munyawana Population as a Case Study. Plos One; 2011. p. 6.

    Google Scholar 

  • Dubna S, Langrova I, Jankovska I, Vadlejch J, Pekar S, Napravnik J, et al. Contamination of soil with Toxocara eggs in urban (Prague) and rural areas in the Czech Republic. Vet Parasitol. 2007;144:81–6.

    CAS  PubMed  Google Scholar 

  • Edelman A, Jensen JT, Bulechowsky M, Cameron J. Combined oral contraceptives and body weight: do oral contraceptives cause weight gain? A primate model. Hum Reprod. 2011;26: 330–6.

    CAS  PubMed  Google Scholar 

  • Ellerman DA, Cohen DJ, Weigel Munoz M, Da Ros VG, Ernesto JI, Tollner TL, et al. Immunologic behavior of human cysteine-rich secretory protein 1 (hCRISP1) in primates: prospects for immunocontraception. Fertil Steril. 2010;93:2551–6.

    CAS  PubMed  Google Scholar 

  • Farquhar VJ, McCue PM, Carnevale EM, Nett TM, Squires EL. Deslorelin acetate (Ovuplant) therapy in cycling mares: effect of implant removal on FSH secretion and ovarian function. Equine Vet J. 2002;34:417–20.

    CAS  PubMed  Google Scholar 

  • Fayrer-Hosken RA, Bertschinger HJ, Kirkpatrick JF, Grobler D, Lamberski N, Honneyman G, et al. Contraceptive potential of the porcine zona pellucida vaccine in the African elephant (Loxodonta africana). Theriogenology. 1999;52:835–46.

    CAS  PubMed  Google Scholar 

  • Felnerova D, Viret JF, Gluck R, Moser C. Liposomes and virosomes as delivery systems for antigens, nucleic acids and drugs. Curr Opin Biotechnol. 2004;15:518–29.

    CAS  PubMed  Google Scholar 

  • Fernando P. Managing ‘problem elephants’. Loris [Online]. 2011;25. http://www.ccrsl.org/Downloads/Fernando-10-ProblemEles.pdf.

  • Fernando P, Wikramanayake ED, Janaka HK, Jayasinghe LKA, Gunawardena M, Kotagama SW, et al. Ranging behavior of the Asian elephant in Sri Lanka. MAMBIO Mamm Biol. 2008;73:2–13.

    Google Scholar 

  • Fernando P, Pastorini J, Leimgruber P, Prasad T. Problem-elephant translocation: translocating the problem and the elephant? PLoS One. 2012;7:e50917.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Ferro VA. Adjuvants and vaccine delivery systems. In:Novel approaches to vaccine research. Hefferon, K. L. (ed.)^(eds). Kerala, India: Research Signpost; 2011.

    Google Scholar 

  • Figueiredo L, Cadete A, Goncalves LMD, Corvo ML, Almeida AJ. Intranasal immunisation of mice against Streptococcus equi using positively charged nanoparticulate carrier systems. Vaccine. 2012;30:6551–8.

    CAS  PubMed  Google Scholar 

  • Fry T, Van Dalen K, Hurley J, Nash P. Mucosal adjuvants to improve wildlife rabies vaccination. J Wildl Dis. 2012;48:1042–6.

    CAS  PubMed  Google Scholar 

  • Goldberg E, Herr J. LDH-C4 as a contraceptive vaccine. In: Gupta S, editor. Reproductive immunology. Amsterdam: Springer; 2000.

    Google Scholar 

  • Gormley E, Corner LAL. Control Strategies for wildlife tuberculosis in Ireland. Transbound Emerg Dis. 2013;60:128–35.

    PubMed  Google Scholar 

  • Gu W, Holland M, Janssens P, Seamark R, Kerr P. Immune response in rabbit ovaries following infection of a recombinant myxoma virus expressing rabbit zona pellucida protein B. Virology. 2004;318:516–23.

    CAS  PubMed  Google Scholar 

  • Hardy CM. Current status of virally vectored immunocontraception for biological control of mice. Soc Reprod Fertil Suppl. 2007;63:495–506.

    CAS  PubMed  Google Scholar 

  • Hardy CM, Hinds LA, Kerr PJ, Lloyd ML, Redwood AJ, Shellam GR, et al. Biological control of vertebrate pests using virally vectored immunocontraception. J Reprod Immunol. 2006;71:102–11.

    CAS  PubMed  Google Scholar 

  • Herbert CA, Trigg TE. Applications of GnRH in the control and management of fertility in female animals. Anim Reprod Sci. 2005;88:141–53.

    CAS  PubMed  Google Scholar 

  • Herbert CA, Trigg TE, Renfree MB, Shaw G, Eckery DC, Cooper DW. Effects of a gonadotropin-releasing hormone agonist implant on reproduction in a male marsupial, Macropus eugenii. Biol Reprod. 2004;70:1836–42.

    CAS  PubMed  Google Scholar 

  • Herbert CA, Trigg TE, Renfree MB, Shaw G, Eckery DC, Cooper DW. Long-term effects of deslorelin implants on reproduction in the female tammar wallaby (Macropus eugenii). Reproduction. 2005;129:361–9.

    CAS  PubMed  Google Scholar 

  • Herbert CA, Eckery DC, Trigg TE, Cooper DW. Chronic treatment of male tammar wallabies with deslorelin implants during pouch life: effects on development, puberty, and reproduction in adulthood. Biol Reprod. 2007;76:1054–61.

    CAS  PubMed  Google Scholar 

  • Herr JC, Flickinger CJ, Homyk M, Klotz K, John E. Biochemical and morphological characterization of the intraacrosomal antigen Sp-10 from human sperm. Biol Reprod. 1990;42:181–93.

    CAS  PubMed  Google Scholar 

  • Holland MK, Andrews J, Clarke H, Walton C, Hinds LA. Selection of antigens for use in a virus-vectored immunocontraceptive vaccine: PH-20 as a case study. Reprod Fertil Dev. 1997;9:117–24.

    CAS  PubMed  Google Scholar 

  • Holland OJ, Cowan PE, Gleeson DM, Duckworth JA, Chamley LW. MHC haplotypes and response to immunocontraceptive vaccines in the brushtail possum. J Reprod Immunol. 2009;82:57–65.

    CAS  PubMed  Google Scholar 

  • Hurley JC, Johnston JJ. Poly(methyl methacrylate) synthetic grit formulations sustain the delivery of nicarbazin, a contraceptive agent, in pest waterfowl. J Contr Release. 2002;85:135–43.

    CAS  Google Scholar 

  • Hynes EF, Nave CD, Shaw G, Renfree MB. Effects of levonorgestrel on ovulation and oestrous behaviour in the female tammar wallaby. Reprod Fertil Dev. 2007;19:335–40.

    CAS  PubMed  Google Scholar 

  • Hynes EF, Handasyde KA, Shaw G, Renfree MB. Levonorgestrel, not etonogestrel, provides contraception in free-ranging koalas. Reprod Fertil Dev. 2010;22:913–9.

    CAS  PubMed  Google Scholar 

  • Janne OA, Zook BC, Didolkar AK, Sundaram K, Nash HA. The roles of estrogen and progestin in producing deciduosarcoma and other lesions in the rabbit. Toxicol Pathol. 2001;29:417–21.

    CAS  PubMed  Google Scholar 

  • Jessup DA. The welfare of feral cats and wildlife. JAVMA J Am Vet Med Assoc. 2004;225:1377–83.

    Google Scholar 

  • Johnson CA, Thompson DL, Cartmill JA. Effects of deslorelin acetate implants in horses: single implants in stallions and steroid-treated geldings and multiple implants in mares. J Anim Sci. 2003;81:1300–7.

    CAS  PubMed  Google Scholar 

  • Junaidi A, Williamson PE, Cummins JM, Martin GB, Blackberry MA, Trigg TE. Use of a new drug delivery formulation of the gonadotrophin-releasing hormone analogue Deslorelin for reversible long-term contraception in male dogs. Reprod Fertil Dev. 2003;15:317–22.

    CAS  PubMed  Google Scholar 

  • Khan SA, Jadhav SV, Suryawanshi AR, Bhonde GS, Gajbhiye RK, Khole VV. Evaluation of contraceptive potential of a novel epididymal sperm protein SFP2 in a mouse model. Am J Reprod Immunol. 2011;66:185–98.

    CAS  PubMed  Google Scholar 

  • Killian G, Kreeger TJ, Rhyan J, Fagerstone K, Miller L. Observations on the use of GonaCon in captive female elk (Cervus elaphus). J Wildl Dis. 2009;45:184–8.

    PubMed  Google Scholar 

  • Kirkpatrick JF, Turner A. Achieving population goals in a long-lived wildlife species (Equus caballus) with contraception. Wildl Res. 2008;35:513–9.

    Google Scholar 

  • Kirkpatrick JF, Turner JW, Liu IKM, FayrerHosken R, Rutberg AT. Case studies in wildlife immunocontraception: wild and feral equids and white-tailed deer. Reprod Fertil Dev. 1997;9:105–10.

    CAS  PubMed  Google Scholar 

  • Kirkpatrick JF, Lyda RO, Frank KM. Contraceptive vaccines for wildlife: a review. Am J Reprod Immunol. 2011;66:40–50.

    PubMed  Google Scholar 

  • Knobel DL, Cleaveland S, Coleman PG, Fevre EM, Meltzer MI, Miranda MEG, et al. Re-evaluating the burden of rabies in Africa and Asia. Bull World Health Organ. 2005;83:360–8.

    PubMed Central  PubMed  Google Scholar 

  • Kutzler M, Wood A. Non-surgical methods of contraception and sterilization. Theriogenology. 2006;66:514–25.

    CAS  PubMed  Google Scholar 

  • Ladd A, Tsong YY, Walfield AM, Thau R. Development of an antifertility vaccine for pets based on active immunization against luteinizing-hormone-releasing hormone. Biol Reprod. 1994;51:1076–83.

    CAS  PubMed  Google Scholar 

  • Lea IA, van Lierop MJC, Widgren EE, Grootenhuis A, Wen Y, van Duin M, et al. A chimeric sperm peptide induces antibodies and strain-specific reversible infertility in mice. Biol Reprod. 1998;59:527–36.

    CAS  PubMed  Google Scholar 

  • Levy JK. Contraceptive vaccines for the humane control of community cat populations. Am J Reprod Immunol. 2011;66:63–70.

    PubMed  Google Scholar 

  • Levy JK, Crawford PC. Humane strategies for controlling feral cat populations. JAVMA J Am Vet Med Assoc. 2004;225:1354–60.

    Google Scholar 

  • Levy JK, Mansour M, Crawford PC, Pohajdak B, Brown RG. Survey of zona pellucida antigens for immunocontraception of cats. Theriogenology. 2005;63:1334–41.

    PubMed  Google Scholar 

  • Li H, Ding X, Guo C, Guan H, Xiong C. Immunization of male mice with B-cell epitopes in transmembrane domains of CatSper1 inhibits fertility. Fertil Steril. 2012;97:445–52.

    CAS  PubMed  Google Scholar 

  • Lincoln G, Anderson R, Anderson H. Progestagen depot with or without testosterone: a strategy for regulating fertility in male elephants. Expert consultation on the control of wild elephant populations. Utrecht: Office for International Co-operation, Faculty of Veterinary Medicine, Utrecht University, The Netherlands; 2004.

    Google Scholar 

  • Locke SL, Cook MW, Harveson LA, Davis DS, Lopez RR, Silvy NJ, et al. Effectiveness of Spayvac (R) for reducing white-tailed deer fertility. J Wildl Dis. 2007a;43:726–30.

    PubMed  Google Scholar 

  • Locke SL, Cook MW, Harveson LA, Davis DS, Lopez RR, Silvy NJ, et al. Effectiveness of Spayvac for reducing white-tailed deer fertility. J Wildl Dis. 2007b;43:726–30.

    PubMed  Google Scholar 

  • Mann JF, Shakir E, Carter KC, Mullen AB, Alexander J, Ferro VA. Lipid vesicle size of an oral influenza vaccine delivery vehicle influences the Th1/Th2 bias in the immune response and protection against infection. Vaccine. 2009;27:3643–9.

    CAS  PubMed  Google Scholar 

  • Marks CA. Bait-delivered cabergoline for the reproductive control of the red fox (Vulpes vulpes): estimating mammalian non-target risk in south-eastern Australia. Reprod Fertil Dev. 2001;13:499–510.

    CAS  PubMed  Google Scholar 

  • Massei G, Jones A, Platt T, Cowan DP. Iophenoxic acid as a long-term marker for wild boar. J Wildl Manage. 2009;73:458–61.

    Google Scholar 

  • Mayle BA, Broome AC. Changes in the impact and control of an invasive alien: the grey squirrel (Sciurus carolinensis) in Great Britain, as determined from regional surveys. Pest Manag Sci. 2013;69:323–33.

    CAS  PubMed  Google Scholar 

  • Menkhorst EM, Cui S, Selwood L. Novel immunocontraceptive targets in mammals: uterine secretions and the conceptus; a marsupial approach. Reproduction. 2008;136:471–80.

    CAS  PubMed  Google Scholar 

  • Miller LA, Gionfriddo JP, Fagerstone KA, Rhyan JC, Killian GJ. The single-shot GnRH immunocontraceptive vaccine (GonaCon) in white-tailed deer: comparison of several GnRH preparations. Am J Reprod Immunol. 2008;60:214–23.

    CAS  PubMed  Google Scholar 

  • Monier L. Metabolic risks of oral contraception. Rev Int Pediatr. 1988;178:64–5.

    PubMed  Google Scholar 

  • Moore HDM, Jenkins NM, Wong C. Immunocontraception in rodents: a review of the development of a sperm-based immunocontraceptive vaccine for the grey squirrel (Sciurus carolinensis). Reprod Fertil Dev. 1997;9:125–9.

    CAS  PubMed  Google Scholar 

  • Moudgal NR, Ravindranath N, Murthy GS, Dighe RR, Aravindan GR, Martin F. Long-term contraceptive efficacy of vaccine of ovine follicle-stimulating hormone in male bonnet monkeys (Macaca radiata). J Reprod Fertil. 1992;96:91–102.

    CAS  PubMed  Google Scholar 

  • Mulatti P, Ferre N, Patregnani T, Bonfanti L, Marangon S. Geographical information systems in the management of the 2009-2010 emergency oral anti-rabies vaccination of foxes in north-eastern Italy. Geospat Health. 2011;5:217–26.

    PubMed  Google Scholar 

  • Munks MW. Progress in development of immunocontraceptive vaccines for permanent non-surgical sterilization of cats and dogs. Reprod Domest Anim. 2012;47:223–7.

    PubMed  Google Scholar 

  • Nation A, Cui S, Selwood L. Vesicle-associated protein 1: a novel ovarian immunocontraceptive target in the common brushtail possum, Trichosurus vulpecula. Reproduction. 2008;136: 657–65.

    CAS  PubMed  Google Scholar 

  • Nave CD, Shaw G, Short RV, Renfree MB. Contraceptive effects of levonorgestrel implants in a marsupial. Reprod Fertil Dev. 2000;12:81–6.

    CAS  PubMed  Google Scholar 

  • Nave CD, Coulson G, Short RV, Poiani A, Shaw G, Renfree MB. Long-term fertility control in the kangaroo and the wallaby using levonorgestrel implants. Reproduction. 2002;71–80.

    Google Scholar 

  • Naz RK. Antisperm contraceptive vaccines: where we are and where we are going? Am J Reprod Immunol. 2011;66:5–12.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Naz RK, Alexander NJ, Isahakia M, Hamilton MS. Monoclonal-antibody to a human germ-cell membrane glycoprotein that inhibits fertilization. Science. 1984;225:342–4.

    CAS  PubMed  Google Scholar 

  • Nie GY, Butt AR, Salamonsen LA, Findlay JK. Hormonal and non-hormonal agents at implantation as targets for contraception. Reprod Fertil Dev. 1997;9:65–76.

    CAS  PubMed  Google Scholar 

  • Nikolovski S, Lloyd ML, Harvey N, Hardy CM, Shellam GR, Redwood AJ. Overcoming innate host resistance to vaccination: employing a genetically distinct strain of murine cytomegalovirus avoids vector-mediated resistance to virally vectored immunocontraception. Vaccine. 2009;27:5226–32.

    CAS  PubMed  Google Scholar 

  • Nol P, Palmer MV, Waters WR, Aldwell FE, Buddle BM, Triantis JM, et al. Efficacy of oral and parenteral routes of Mycobacterium bovis bacille Calmette-Guerin vaccination against experimental bovine tuberculosis in white-tailed deer (Odocoileus virginianus): a feasibility study. J Wildl Dis. 2008;44:247–59.

    CAS  PubMed  Google Scholar 

  • O'Hern PA, Bambra CS, Isahakia M, Goldberg E. Reversible contraception in female baboons immunized with a synthetic epitope of sperm-specific lactate dehydrogenase. Biol Reprod. 1995;52:331–9.

    PubMed  Google Scholar 

  • Olivera P, Menezes D, Trout R, Buckle A, Geraldes P, Jesus J. Successful eradication of the European rabbit (Oryctolagus cuniculus) and house mouse (Mus musculus) from the island of Selvagem Grande (Macaronesian archipelago), in the Eastern Atlantic. Integr Zool. 2010;5:70–83.

    PubMed  Google Scholar 

  • Patton ML, Bashaw MJ, del Castillo SM, Jochle W, Lamberski N, Rieches R, et al. Long-term suppression of fertility in female giraffe using the GnRH agonist deslorelin as a long-acting implant. Theriogenology. 2006;66:431–8.

    CAS  PubMed  Google Scholar 

  • Powers JG, Baker DL, Davis TL, Conner MM, Lothridge AH, Nett TM. Effects of gonadotropin-releasing hormone immunization on reproductive function and behavior in captive female rocky mountain Elk (Cervus elaphus nelsoni). Biol Reprod. 2011;85:1152–60.

    CAS  PubMed  Google Scholar 

  • Primakoff P, Lathrop W, Woolman L, Cowan A, Myles D. Fully effective contraception in male and female guinea-pigs immunized with the sperm protein Ph-20. Nature. 1988;335:543–6.

    CAS  PubMed  Google Scholar 

  • Pukazhenthi B, Comizzoli P, Travis AJ, Wildt DE. Applications of emerging technologies to the study and conservation of threatened and endangered species. Reprod Fertil Dev. 2006;18:77–90.

    PubMed  Google Scholar 

  • Rao KS, Maikhuri RK, Nautiyal S, Saxena KG. Crop damage and livestock depredation by wildlife: a case study from Nanda Devi Biosphere Reserve, India. J Environ Manage. 2002;66:317–27.

    CAS  PubMed  Google Scholar 

  • Rattner BA, Horak KE, Lazarus RS, Eisenreich KM, Meteyer CU, Volker SF, et al. Assessment of toxicity and potential risk of the anticoagulant rodenticide diphacinone using Eastern screech-owls (Megascops asio). Ecotoxicology. 2012;21:832–46.

    CAS  PubMed  Google Scholar 

  • Robbins SC, Jelinski MD, Stotish RL. Assessment of the immunological and biological efficacy of two different doses of a recombinant GnRH vaccine in domestic male and female cats (Felis catus). J Reprod Immunol. 2004;64:107–19.

    CAS  PubMed  Google Scholar 

  • Rocke TE, Smith SR, Stinchcomb DT, Osorio JE. Immunization of black-tailed prairie dog against plague through consumption of vaccine-laden baits. J Wildl Dis. 2008;44:930–7.

    PubMed  Google Scholar 

  • Salhab AS, Gharaibeh MN, Shomaf MS, Amro BI. Meloxicam inhibits rabbit ovulation. Contraception. 2001;63:329–33.

    CAS  PubMed  Google Scholar 

  • Santhanam R, Naz RK. Novel human testis-specific cDNA: molecular cloning, expression and immunobiological effects of the recombinant protein. Mol Reprod Dev. 2001;60:1–12.

    CAS  PubMed  Google Scholar 

  • Scheerlinck JP, Greenwood DL. Particulate delivery systems for animal vaccines. Methods. 2006;40:118–24.

    CAS  PubMed  Google Scholar 

  • Schneider F, Tomek W, Grundker C. Gonadotropin-releasing hormone (GnRH) and its natural analogues: a review. Theriogenology. 2006;66:691–709.

    CAS  PubMed  Google Scholar 

  • Sekhon BS, Kamboj SR. Inorganic nanomedicine-Part 2. Nanomed Nanotechnol Biol Med. 2010;6:612–8.

    CAS  Google Scholar 

  • Seow Y, Wood MJ. Biological gene delivery vehicles: beyond viral vectors. Mol Ther. 2009;17:767–77.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Shackelford N, Renton M, Perring MP, Hobbs RJ. Modeling disturbance-based native invasive species control and its implications for management. Ecol Appl. 2013;23:1331–44.

    PubMed  Google Scholar 

  • Shankar S, Mohapatra B, Suri A. Cloning of a novel human testis mRNA specifically expressed in testicular haploid germ cells, having unique palindromic sequences and encoding a leucine zipper dimerization motif. Biochem Biophys Res Commun. 1998;243:561–5.

    CAS  PubMed  Google Scholar 

  • Shetty J, Wolkowicz MJ, Digilio LC, Klotz KL, Jayes FL, Diekman AB, et al. SAMP14, a novel, acrosomal membrane-associated, glycosylphosphatidylinositol-anchored member of the Ly-6/urokinase-type plasminogen activator receptor superfamily with a role in sperm-egg interaction. J Biol Chem. 2003;278:30506–15.

    CAS  PubMed  Google Scholar 

  • Shideler SE, Stoops MA, Gee NA, Howell JA, Lasley BL. Use of porcine zona pellucida (PZP) vaccine as a contraceptive agent in free-ranging Tule Elk (Cervus elaphus nannodes). Reproduction. 2002;60:169–76.

    CAS  PubMed  Google Scholar 

  • Simmons JG, Hamner CE. Inhibition of estrus in the dog with testosterone implants. Am J Vet Res. 1973;34:1409–19.

    CAS  PubMed  Google Scholar 

  • Srinath BR, Wickings EJ, Witting C, Nieschlag E. Active immunization with follicle-stimulating-hormone for fertility-control – a 4 1/2-year study in male rhesus-monkeys. Fertil Steril. 1983;40:110–7.

    CAS  PubMed  Google Scholar 

  • Suri A. Sperm specific proteins-potential candidate molecules for fertility control. Reprod Biol Endocrinol. 2004;2:10.

    PubMed Central  PubMed  Google Scholar 

  • Telford 3rd SR, Cunningham JA, Waltari E, Hu L. Nest box-deployed bait for delivering oral vaccines to white-footed mice. Ticks Tick Borne Dis. 2011;2:151–5.

    PubMed Central  PubMed  Google Scholar 

  • Tyndale-Biscoe CH. Virus-vectored immunocontraception of feral mammals. Reprod Fertil Dev. 1994;6:281–7.

    CAS  PubMed  Google Scholar 

  • Walcher P, Cui XL, Arrow JA, Scobie S, Molinia FC, Cowan PE, et al. Bacterial ghosts as a delivery system for zona pellucida-2 fertility control vaccines for brushtail possums (Trichosurus vulpecula). Vaccine. 2008;26:6832–8.

    CAS  PubMed  Google Scholar 

  • Wang DG, Huang TH, Xie QD, An G. Investigation of recombinant mouse sperm protein izumo as a potential immunocontraceptive antigen. Am J Reprod Immunol. 2008;59:225–34.

    CAS  PubMed  Google Scholar 

  • Wang M, Lv Z, Shi J, Hu Y, Xu C. Immunocontraceptive potential of the Ig-like domain of Izumo. Mol Reprod Dev. 2009;76:794–801.

    CAS  PubMed  Google Scholar 

  • Webster DM, Sundaram P, Byrne ME. Injectable nanomaterials for drug delivery: carriers, targeting moieties, and therapeutics. Eur J Pharm Biopharm [Online]. 2013. http://www.ncbi.nlm.nih.gov/pubmed/23313176. Accessed Jan 8 2013

  • Wheaton CJ, Savage A, Shukla A, Neiffer D, Qu W, Sun Y, et al. The use of long acting subcutaneous levonorgestrel (LNG) gel depot as an effective contraceptive option for cotton-top Tamarins (Saguinus oedipus). Zoo Biol. 2011;30:498–522.

    CAS  PubMed  Google Scholar 

  • Wickings EJ, Nieschlag E. Suppression of spermatogenesis over two years in rhesus monkeys actively immunized with follicle-stimulating hormone. Fertil Steril. 1980;34:269–74.

    CAS  PubMed  Google Scholar 

  • Wu X, Hu R, Zhang Y, Dong G, Rupprecht CE. Reemerging rabies and lack of systemic surveillance in People's Republic of China. Emerg Infect Dis. 2009;15:1159–64.

    PubMed Central  PubMed  Google Scholar 

  • Yang LH, Li JT, Yan P, Liu HL, Zeng SY, Wu YZ, et al. Follicle-stimulating hormone receptor (FSHR)-derived peptide vaccine induced infertility in mice without pathological effect on reproductive organs. Reprod Fertil Dev. 2011;23:544–50.

    CAS  PubMed  Google Scholar 

  • Zaman M, Chandrudu S, Toth I. Strategies for intranasal delivery of vaccines. Drug Deliv Transl Res. 2013;3:100–9.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Zhang LH, Tian XS, Zhou FZ. Intranasal administration of CpG oligonucleotides induces mucosal and systemic Type 1 immune responses and adjuvant activity to porcine reproductive and respiratory syndrome killed virus vaccine in piglets in vivo. Int Immunopharmacol. 2007;7:1732–40.

    CAS  PubMed  Google Scholar 

  • Zook BC, Janne OA, Abraham AA, Nash HA. The development and regression of deciduosarcomas and other lesions caused by estrogens and progestins in rabbits. Toxicol Pathol. 2001;29:411–6.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, Imperial College London, South Kensington, London, UK

    Deborah Garside B.Sc., Ph.D.

  2. Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK

    Ayman Gebril B.V.Sc., Ph.D. & Valerie A. Ferro B.Sc., Ph.D.

  3. Department of Industrial Pharmacy, Faculty of Pharmacy, University of Tripoli, Tripoli, Libya

    Manal Alsaadi Ph.D.

Authors
  1. Deborah Garside B.Sc., Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ayman Gebril B.V.Sc., Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Manal Alsaadi Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Valerie A. Ferro B.Sc., Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Valerie A. Ferro B.Sc., Ph.D. .

Editor information

Editors and Affiliations

  1. Department of Human Metabolism, The University of Sheffield, Sheffield, United Kingdom

    William V. Holt

  2. Center for Species Survival, Smithsonian Conservation Biology Institute, Front Royal, Virginia, USA

    Janine L. Brown

  3. Center for Species Survival, Smithsonian Conservation Biology Institute, Front Royal, Virginia, USA

    Pierre Comizzoli

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Science+Business Media New York

About this chapter

Cite this chapter

Garside, D., Gebril, A., Alsaadi, M., Ferro, V.A. (2014). Fertility Control in Wildlife: Review of Current Status, Including Novel and Future Technologies. In: Holt, W., Brown, J., Comizzoli, P. (eds) Reproductive Sciences in Animal Conservation. Advances in Experimental Medicine and Biology, vol 753. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0820-2_18

Download citation

Publish with us

Policies and ethics

Search

Navigation