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Role of Aberrant Protein Modification, Assembly, and Localization in Cloned Embryo Phenotypes

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Posttranslational Protein Modifications in the Reproductive System

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 759))

Abstract

Aberrant post-translational modifications of proteins contribute markedly to the abnormal characteristics of cloned embryos. This review summarizes aberrant aspects of protein modifications and protein interactions, taking an inside–outside view to the cell. These aberrant aspects affect a range of processes including the control of chromatin structure, expression of pluripotency genes, propagation of epigenetic inheritance, protein trafficking, localization and signaling, cytoskeletal structure, mitosis, and correct localization of membrane proteins. By observing these aberrant features of cloned embryos, how they arise, and their impacts on development, it is possible to gain insight into normal development and identify novel strategies for enhancing cloning outcomes.

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Acknowledgment

The work in the author’s laboratory is supported in part by a grant from the National Institute of Child Health and Human Development/National Institutes of Health (HD43092).

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Authors and Affiliations

  1. Department of Animal Science, College of Agriculture and Natural Resources, and The Reproductive and Developmental Sciences Program, Michigan State University, 474 S. Shaw Lane, Room 1230E, East Lansing, MI, 48824, USA

    Keith E. Latham

  2. Department of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, 474 S. Shaw Lane, Room 1290E, East Lansing, MI, 48824, USA

    Keith E. Latham

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  1. Keith E. Latham
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Correspondence to Keith E. Latham .

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  1. Division of Animal Sciences, and Departments of Obstetrics, Gynecology and Women's Health, University of Missouri, Columbia, Missouri, USA

    Peter Sutovsky

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Latham, K.E. (2014). Role of Aberrant Protein Modification, Assembly, and Localization in Cloned Embryo Phenotypes. In: Sutovsky, P. (eds) Posttranslational Protein Modifications in the Reproductive System. Advances in Experimental Medicine and Biology, vol 759. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0817-2_7

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  • DOI: https://doi.org/10.1007/978-1-4939-0817-2_7

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