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Posttranslational Protein Modifications in the Reproductive System pp 89–110Cite as

Deubiquitinating Enzymes in Oocyte Maturation, Fertilization and Preimplantation Embryo Development

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 759))

Abstract

Post-translational modifications of cellular proteins by ubiquitin and ubiquitin-like protein modifiers are important regulatory events involved in diverse aspects of gamete and embryo physiology including oocyte maturation, fertilization and development of embryos to term. Deubiquitinating enzymes (DUBs) regulate proteolysis by reversing ubiquitination, which targets proteins to the 26S proteasome. The ubiquitin C-terminal hydrolases (UCHs) comprise are DUBs that play a role in the removal of multi-ubiquitin chains. We review here the roles of UCHs in oocytes maturation, fertilization and development in mouse, bovine, porcine and rhesus monkeys. Oocyte UCHs contributes to fertilization and embryogenesis by regulating the physiology of the oocyte and blastomere cortex as well as oocyte spindle. Lack of UCHs in embryos reduces fertilization, while mutant embryos fail to undergo compaction and blastocyst formation. In addition to advancing our understanding of reproductive process, research on the role of deubiquitinating enzymes will allow us to better understand and treat human infertility, and to optimize reproductive performance in agriculturally important livestock species.

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Acknowledgments

This work was supported in part by a grant from the National Institutes of Health, National Institute of Child Health and Human Development, HD 43092 to Keith E. Latham, by Agriculture and Food Research Initiative Competitive Grant no. 2011-67015-20025 from the USDA National Institute of Food and Agriculture to Peter Sutovsky, and by seed funding from the Food for the Twenty-first Century Program of the University of Missouri to Peter Sutovsky.

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Authors and Affiliations

  1. MOFA Global, International Center For Biotechnology (ICB), 2633 State Road 78, Mount Horeb, WI, USA

    Namdori R. Mtango

  2. Department of Animal Science, College of Agriculture and Natural Resources, Michigan State University, 474 S. Shaw Lane, Room 1230E, East Lansing, MI, 48824, USA

    Keith E. Latham

  3. Department of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, 474 S. Shaw Lane, Room 1290E, East Lansing, MI, 48824, USA

    Keith E. Latham

  4. Division of Animal Science, and Departments of Obstetrics, Gynecology and Women’s Health, University of Missouri, S141 ASRC, 920 East Campus Drive, Columbia, MO, 65211-5300, USA

    Peter Sutovsky

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  1. Namdori R. Mtango
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  2. Keith E. Latham
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  3. Peter Sutovsky
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Correspondence to Namdori R. Mtango .

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  1. Division of Animal Sciences, and Departments of Obstetrics, Gynecology and Women's Health, University of Missouri, Columbia, Missouri, USA

    Peter Sutovsky

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Mtango, N.R., Latham, K.E., Sutovsky, P. (2014). Deubiquitinating Enzymes in Oocyte Maturation, Fertilization and Preimplantation Embryo Development. In: Sutovsky, P. (eds) Posttranslational Protein Modifications in the Reproductive System. Advances in Experimental Medicine and Biology, vol 759. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0817-2_5

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