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Posttranslationally Modified Tubulins and Other Cytoskeletal Proteins: Their Role in Gametogenesis, Oocyte Maturation, Fertilization and Pre-implantation Embryo Development

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Posttranslational Protein Modifications in the Reproductive System

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 759))

Abstract

The cytoskeleton, mainly consisting of microtubules, intermediate filaments and microfilaments, along with cytoskeleton associated and interconnecting proteins as well as the centrosome, plays enormously important roles in all stages of embryogenesis and undergoes significant changes to accommodate a diversity of cellular functions during gametogenesis, oocyte maturation, fertilization and pre-implantation embryo development. The varied functions of the cytoskeleton can be accomplished on many different levels, among which are a diversity of different posttranslational modifications (PTMs), chemical modifications that regulate activity, localization and interactions with other cellular molecules. PTMs of the cytoskeleton, including phosphorylation, glycosylation, ubiquitination, detyrosination/tyrosination, (poly)glutamylation and (poly)glycylation, acetylation, sumoylation, and palmitoylation, will be addressed in this chapter. Focus will be on (1) Microtubules, microtubule organizing centers (centrosomes), intermediate filaments, microfilaments and their PTMs; (2) Cytoskeletal functions and cytoskeletal PTMs during gametogenesis and oocyte maturation; and (3) Cytoskeletal functions and cytoskeletal PTMs during fertilization and pre-implantation embryo development.

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Authors and Affiliations

  1. Department of Veterinary Pathobiology, University of Missouri, 1600 E Rollins Street, Columbia, MO, 65211, USA

    Heide Schatten

  2. State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, #1 Beichen West Road, Chaoyang District, Beijing, 100080, China

    Qing-Yuan Sun

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  1. Division of Animal Sciences, and Departments of Obstetrics, Gynecology and Women's Health, University of Missouri, Columbia, Missouri, USA

    Peter Sutovsky

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Schatten, H., Sun, QY. (2014). Posttranslationally Modified Tubulins and Other Cytoskeletal Proteins: Their Role in Gametogenesis, Oocyte Maturation, Fertilization and Pre-implantation Embryo Development. In: Sutovsky, P. (eds) Posttranslational Protein Modifications in the Reproductive System. Advances in Experimental Medicine and Biology, vol 759. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0817-2_4

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