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Next-Generation Sequencing for Gene Panels

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Genomic Applications in Pathology

Abstract

Many molecular diagnostics laboratories are implementing next-generation sequencing (NGS)-based gene panels by harnessing the power of massively parallel sequencing technologies. NGS has dramatically expanded the capabilities of laboratories by multiplexing and streamlining DNA sequencing workflows. Replacing traditional target amplification techniques with in-solution enrichment technologies has simplified sequencing template preparation, greatly increasing the productivity of individual laboratories. Improved efficiency of molecular genetic testing, driven by the development and implementation of comprehensive disease-targeted gene panels, is propelling the advancement of genomic medicine.

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Author information

Authors and Affiliations

  1. Department of Pathology, University of Washington, Seattle, WA, USA

    Michael O. Dorschner

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  1. Michael O. Dorschner
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Editor information

Editors and Affiliations

  1. Departments of Pathology, Oncology and Urology, Johns Hopkins University, Baltimore, Maryland, USA

    George Jabboure Netto

  2. Department of Pathology, Stanford University School of Medicine, Stanford, California, USA

    Iris Schrijver

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Dorschner, M.O. (2015). Next-Generation Sequencing for Gene Panels. In: Netto, G., Schrijver, I. (eds) Genomic Applications in Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0727-4_15

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  • DOI: https://doi.org/10.1007/978-1-4939-0727-4_15

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-0726-7

  • Online ISBN: 978-1-4939-0727-4

  • eBook Packages: MedicineMedicine (R0)

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