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Genes and the Motivation to Use Substances pp 129–139Cite as

Genomics of Impulsivity: Integrating Genes and Neuroscience

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Part of the book series: Nebraska Symposium on Motivation ((NSM,volume 61))

Abstract

The identification of naturally occurring functional genetic variants that modulate impulsivity has enabled better understanding of pathways that lead to impulsivity and of ways the pathways and genes can also influence other behaviors in a pleiotropic fashion. The effects of rare and common variants of MAOA and HTR2B genes are dependent on context. These contexts include stress and endocrine exposures with genotype effect being dependent on the environmental interaction and genetic contexts, with some alleles being present only in particular populations or families.

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Acknowledgments

I thank Laura Bevilacqua, Irv Gottesman, Zhifeng Zhou, Francesca Ducci, Rickard Sjoberg, Jaakko Kaprio, Matti Virkkunen, Elliot Stein, Marcus Munafo, Anil Malhotra, Colin Hodgkinson, Jon-Kar Zubieta, and Luc Maroteaux for discussions that helped inform this paper.

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  1. Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, 20852, Rockville, MD, USA

    David Goldman

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Correspondence to David Goldman .

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  1. Psychology, University of Nebraska-Lincoln, Lincoln, Nebraska, USA

    Scott F. Stoltenberg

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Goldman, D. (2014). Genomics of Impulsivity: Integrating Genes and Neuroscience. In: Stoltenberg, S. (eds) Genes and the Motivation to Use Substances. Nebraska Symposium on Motivation, vol 61. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0653-6_7

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