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A Tale of Two Methods: Combining Near-Infrared Spectroscopy with MRI for Studies of Brain Oxygenation and Metabolism

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Oxygen Transport to Tissue XXXVI

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 812))

Abstract

Combining magnetic resonance imaging (MRI) with near-infrared spectroscopy (NIRS) leads to excellent synergies which can improve the interpretation of either method and can provide novel data with respect to measuring brain oxygenation and metabolism. MRI has good spatial resolution, can detect a range of physiological parameters and is sensitive to changes in deoxyhemoglobin content. NIRS has lower spatial resolution, but can detect, and with specific technologies, quantify, deoxyhemoglobin, oxyhemoglobin, total hemoglobin and cytochrome oxidase. This paper reviews the application of both methods, as a multimodal technology, for assessing changes in brain oxygenation that may occur with changes in functional activation state or metabolic rate. Examples of hypoxia and ischemia are shown. Data support the concept of reduced metabolic rate resulting from hypoxia/ischemia and that metabolic rate in brain is not close to oxygen limitation during normoxia. We show that multimodal MRI and NIRS can provide novel information for studies of brain metabolism.

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Acknowledgments

Work was supported by NSERC, CIHR, endMS, the MS Society of Canada and AIHS.

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Authors and Affiliations

  1. Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada

    Jeff F. Dunn, Nabeela Nathoo & Runze Yang

  2. Department of Radiology, University of Calgary, 3330 Hospital Drive, N.W., Calgary, AB, Canada, T2N 4 N1

    Jeff F. Dunn, Nabeela Nathoo & Runze Yang

  3. Experimental Imaging Centre, University of Calgary, Calgary, AB, Canada

    Jeff F. Dunn

Authors
  1. Jeff F. Dunn
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  2. Nabeela Nathoo
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  3. Runze Yang
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Corresponding author

Correspondence to Jeff F. Dunn .

Editor information

Editors and Affiliations

  1. EPR Center for the Study of Viable Systems, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA

    Harold M. Swartz

  2. Microvascular Measurements, St. Lorenzen, Italy

    David K. Harrison

  3. Synthesizer Inc., Ellicott City, MD, USA

    Duane F. Bruley

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Dunn, J.F., Nathoo, N., Yang, R. (2014). A Tale of Two Methods: Combining Near-Infrared Spectroscopy with MRI for Studies of Brain Oxygenation and Metabolism. In: Swartz, H.M., Harrison, D.K., Bruley, D.F. (eds) Oxygen Transport to Tissue XXXVI. Advances in Experimental Medicine and Biology, vol 812. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0620-8_9

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