Abstract
Understanding the biological mechanism and identifying biomarkers of hemorrhagic shock is important for diagnosis and treatment. We aim to use optical imaging to study how the cerebral blood circulation and metabolism change during the progression of severe hemorrhagic shock, especially the decompensatory stage. We used a multi-parameter (blood pressure (BP), cerebral blood flow (CBF), functional vascular density (FVD), blood oxygenation and mitochondrial NADH signal) cerebral cortex optical imaging system to observe brain hemodynamic change and metabolic alteration of rats in vivo for 4 h. Cerebral circulation and mitochondrial metabolism could be well preserved in the compensatory stage but impaired during the decompensatory stage. The changes of brain hemodynamics and metabolism may provide sensitive indicators for various shock stages including the transition from compensatory stage to decompensatory stage. Our novel imaging observations of hemodynamic and metabolic signals in vivo indicated that the rat brains under hemorrhagic shock suffered irreversible damage which could not be compensated by the autoregulation mechanism, probably due to injured mitochondria.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Cocchi MN, Kimlin E, Walsh M et al (2007) Identification and resuscitation of the trauma patient in shock. Emerg Med Clin N Am 25(3):623–642, vii
Taccone FS, De Backer D (2010) Is cerebral microcirculation really preserved in shock states? Crit Care Med 38(3):1008–1009
Koh IHJ, Menchaca-Diaz JL, Koh TH et al (2010) Microcirculatory evaluation in sepsis. Shock 34(Suppl 1):27–33
Wan Z, Sun S, Ristagno G et al (2010) The cerebral microcirculation is protected during experimental hemorrhagic shock. Crit Care Med 38(3):928–932
Thiemermann C, Szabo C, Mitchell JA et al (1993) Vascular hyporeactivity to vasoconstrictor agents and hemodynamic decompensation in hemorrhagic shock is mediated by nitric oxide. Proc Natl Acad Sci 90:267–271
Song R, Bian H, Wang X et al (2011) Mitochondrial injury underlies hyporeactivity of arterial smooth muscle in severe shock. Am J Hypertens 24(1):45–51
Sun X, Wang Y, Chen S et al (2011) Simultaneous monitoring of intracellular pH changes and hemodynamic response during cortical spreading depression by fluorescence-corrected multimodal optical imaging. Neuroimage 57(3):873–884
Jiang C, Zhang H, Wang J et al (2011) Dedicated hardware processor and corresponding system-on-chip design for real-time laser speckle imaging. J Biomed Opt 16(11):116008
Qiu J, Li P, Luo W et al (2010) Spatiotemporal laser speckle contrast analysis for blood flow imaging with maximized speckle contrast. J Biomed Opt 15(1):016003
Liu S, Li P, Luo Q (2008) Fast blood flow visualization of high-resolution laser speckle imaging data using graphics processing unit. Opt Express 16(19):14321–14329
Li P, Ni S, Zhang L et al (2006) Imaging cerebral blood flow through the intact rat skull with temporal laser speckle imaging. Opt Lett 31(12):1824–1826
Acknowledgments
This work was supported by the National Major Scientific Research Program of China (Grant No. 2011CB910401) and the Science Fund for Creative Research Group of China (Grant No. 61121004) and the Director Fund of Wuhan National Laboratory for Optoelectronics and the Specific International Scientific Cooperation (Grant No. 2010DFR30820).
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer Science+Business Media, LLC
About this paper
Cite this paper
Sun, N., Li, L.Z., Luo, W., Luo, Q. (2014). Cerebral Hemodynamic Change and Metabolic Alteration in Severe Hemorrhagic Shock. In: Swartz, H.M., Harrison, D.K., Bruley, D.F. (eds) Oxygen Transport to Tissue XXXVI. Advances in Experimental Medicine and Biology, vol 812. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0620-8_29
Download citation
DOI: https://doi.org/10.1007/978-1-4939-0620-8_29
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4939-0583-6
Online ISBN: 978-1-4939-0620-8
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)