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Oxygen Transport to Tissue XXXVI pp 203–208Cite as

Effects of Enriched Environment on Hippocampal Neuronal Cell Death and Neurogenesis in Rat Global Ischemia

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 812))

Abstract

Enriched environments reportedly show neuroprotective effects. Here, we evaluated the effect of an enriched environment prior to cerebral ischemia on neuronal cell death and neurogenesis in rats. Male SD rats were housed under standard conditions (SC) or in an enriched environment (EE), then subjected to global ischemia. The Y-maze test and novel object cognition test were used to evaluate cognitive function before and after ischemia. At 7 days post-ischemia, we evaluated hippocampal neuronal cell death with Fluoro-Jade B staining and neurogenesis with BrdU staining. Phosphorylated cAMP response element-binding protein (phospho-CREB) was also evaluated immunohistochemically. The EE + ischemia group showed a significant decrease of cell death post-ischemia compared with the SC + ischemia group. There was no difference in neurogenesis post-ischemia between SC + ischemia and EE + ischemia. The EE + ischemia group showed a significant increase of performance before and after ischemia compared with the SC + ischemia group. Phospho-CREB-positive cells were significantly increased post-ischemia in EE + ischemia compared with SC + ischemia. EE suppressed hippocampal cell death due to global ischemia. Additionally, enhancement of cognitive function before and after ischemia and prevention of cognitive impairment associated with ischemia were observed compared with the controls (rats housed in SC without ischemia). The CREB pathway may play an important role in protection of cognitive ability.

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Author information

Authors and Affiliations

  1. Division of Neurosurgery, Department of Neurological Surgery, Nihon University School of Medicine, 30-1 Oyaguchi-Kamimachi, Itabashi-ku, Tokyo, 173-8610, Japan

    Tomokazu Kato, Takashi Eriguchi, Norio Fujiwara, Yoshihiro Murata, Atsuo Yoshino, Kaoru Sakatani & Yoichi Katayama

  2. Department of Electrical and Electronics Engineering, Nihon University College of Engineering, NEWCAT Institute, Fukushima, Japan

    Kaoru Sakatani

Authors
  1. Tomokazu Kato
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  2. Takashi Eriguchi
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  3. Norio Fujiwara
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  4. Yoshihiro Murata
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  5. Atsuo Yoshino
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  6. Kaoru Sakatani
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  7. Yoichi Katayama
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Corresponding author

Correspondence to Kaoru Sakatani .

Editor information

Editors and Affiliations

  1. EPR Center for the Study of Viable Systems, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA

    Harold M. Swartz

  2. Microvascular Measurements, St. Lorenzen, Italy

    David K. Harrison

  3. Synthesizer Inc., Ellicott City, MD, USA

    Duane F. Bruley

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Kato, T. et al. (2014). Effects of Enriched Environment on Hippocampal Neuronal Cell Death and Neurogenesis in Rat Global Ischemia. In: Swartz, H.M., Harrison, D.K., Bruley, D.F. (eds) Oxygen Transport to Tissue XXXVI. Advances in Experimental Medicine and Biology, vol 812. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0620-8_27

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