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Integrative Weight Management pp 187–200Cite as

Diabesity: The Causes of Our Modern Plague

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Part of the book series: Nutrition and Health ((NH))

Abstract

Diabesity (the spectrum from mild insulin resistance to end-stage diabetes) now affects over one billion people worldwide. From 1983 to 2008 there has been a sevenfold increase in diabetes worldwide, its most extreme form. Metabolic syndrome and its consequences including cardiovascular disease, cancer, and dementia are emerging as the major driver of most chronic diseases of aging. Up to 50 % of diabetics and nearly all prediabetic are undiagnosed. Current strategies of pharmacologic intervention have proven ineffective or harmful. Emerging research clarifies underlying causes of this pandemic of insulin resistance including our refined, nutrient-poor, high-glycemic load diet, sedentary lifestyle, and chronic stress. Novel etiologic factors including environmental toxins, food sensitivities, hormonal dysregulation, gut microbiology, latent infections, nutrient deficiencies, and abnormal gene expression provide important diagnostic considerations and avenues for therapeutic intervention. A whole systems approach based on functional medicine provides a methodology for a comprehensive approach to this life-threatening and economically crippling modern disease.

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Authors and Affiliations

  1. Institute of Functional Medicine, 55 Pittsfield Road, Suite 9, Lenox, MA, 01240, USA

    Mark Hyman MD

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  1. Mark Hyman MD
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Editors and Affiliations

  1. Division of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, Maryland, USA

    Gerard E. Mullin

  2. Weight Management Center, Johns Hopkins Hospital, Baltimore, Maryland, USA

    Lawrence J. Cheskin

  3. Division of Gastroenterology and Hepatology, Brody School of Medicine at East Carolina University, Greenville, North Carolina, USA

    Laura E. Matarese

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Hyman, M. (2014). Diabesity: The Causes of Our Modern Plague. In: Mullin, G., Cheskin, L., Matarese, L. (eds) Integrative Weight Management. Nutrition and Health. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0548-5_12

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