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Studies on Respiratory Disorders pp 85–99Cite as

Pulmonary Infections—Oxidant Injury and Role of Antioxidants

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Abstract

There is an increased oxidative burden in the lungs and the peripheral blood of patients with pulmonary infections. Oxidative stress plays an important role in the injurious and inflammatory responses in lung diseases. The normal system is provided with a defensive control in the form of protective antioxidant machinery. This comprises of enzymatic and non-enzymatic molecules that control the level of oxidative stress generated by reactive species that are actually meant to contain the pathogens. As constitutive antioxidants fall short of their task in case of injury, infection, or inflammation, antioxidants need to be supplied so as to fulfill the requirement. The search is on for effective antioxidant-based therapeutics with appreciable bioavailability and potency. Not only synthetic preparations but natural products are also being tested as valuable antioxidants.

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Conflict of Interest We have no conflicts of interest in the authorship and publication of this article.

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Authors and Affiliations

  1. Department of Biochemistry, Panjab University, Chandigarh, 160014, India

    Bidyalaxmi Devi Leishangthem, Ruchi Rastogi & Archana Bhatnagar

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  1. Bidyalaxmi Devi Leishangthem
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  2. Ruchi Rastogi
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  3. Archana Bhatnagar
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Correspondence to Archana Bhatnagar .

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Editors and Affiliations

  1. Department of Biotechnology, National Institute of Immunology, New Delhi, India

    Nirmal K. Ganguly

  2. Department of Pulmonary Medicine, Postgraduate Institute of Medical Educat, Chandigarh, India

    Surinder K. Jindal

  3. Department of Medicine and Oncology, Johns Hopkins College of Medicine, Baltimore, Maryland, USA

    Shyam Biswal

  4. National Heart & Lung Institute, Imperial College London, London, United Kingdom

    Peter J. Barnes

  5. Department of Pediatrics, Nippon Medical School, Tokyo, Japan

    Ruby Pawankar

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Leishangthem, B.D., Rastogi, R., Bhatnagar, A. (2014). Pulmonary Infections—Oxidant Injury and Role of Antioxidants. In: Ganguly, N., Jindal, S., Biswal, S., Barnes, P., Pawankar, R. (eds) Studies on Respiratory Disorders. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0497-6_5

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