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Phospholipases in Health and Disease pp 211–226Cite as

Phospholipase C Isoform Functions in Immune Cells

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Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 10))

Abstract

Phospholipase C (PLC) family members play critical roles in regulating immune cell functions during inflammatory responses. This chapter discusses how different family members can be activated by G-protein coupled receptors, T-cell receptors, B-cell receptors, and other tyrosine kinase receptors, in addition to many of the pathways that contribute to propagation of signaling through the intracellular signaling events that are mediated by different family members. By understanding these signaling events and immune mechanisms we will be able to better define targets for pharmacological intervention for inflammation and autoimmune diseases.

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Acknowledgments

This work was funded by a startup award through the Texas STARS program to CMV.

Author information

Authors and Affiliations

  1. Department of Biological Sciences, Border Biomedical Research Center, University of Texas at El Paso, 500 W. University Avenue, El Paso, TX, USA

    Charlotte M. Vines

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  1. Charlotte M. Vines
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Correspondence to Charlotte M. Vines .

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  1. I.H. Asper Clinical Research Institute St. Boniface Hospital Research, Winnipeg, Manitoba, Canada

    Paramjit S. Tappia

  2. St. Boniface Hosp. Research, Univ. of Ma Institute of Cardiovascular Sciences, Winnipeg, Manitoba, Canada

    Naranjan S. Dhalla

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© 2014 Springer Science+Business Media New York

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Vines, C.M. (2014). Phospholipase C Isoform Functions in Immune Cells. In: Tappia, P., Dhalla, N. (eds) Phospholipases in Health and Disease. Advances in Biochemistry in Health and Disease, vol 10. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0464-8_13

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