Abstract
Identification and stratification of patients based on risk factors that predict for recurrence and progression of penile cancer are critical for patient and provider understanding of the disease as well as identification of appropriate therapy. Prognostic factors have primarily been studied in two clinical scenarios in penile cancer: (1) the identification of the patient with invasive primary cancer at high risk for developing inguinal lymph node metastases and (2) among those with inguinal lymph node metastases, predicting cancer-specific survival. Nomograms to predict for nodal metastases will allow the provider to carefully select patients for intervention on the lymph nodes while avoiding the potential side effect that such intervention may generate. Furthermore, a clear understanding of the factors which predict for survival will allow for optimal selection of patients for clinical trials.
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AJCC. Penis. In: Edge SB, Byrd DR, Compton CC, et al., editors. AJCC cancer staging manual. 7th ed. New York: Springer; 2010. p. 447–55.
Fraley EE, Zhang G, Manivel C, Niehans GA. The role of ilioinguinal lymphadenectomy and significance of histological differentiation in treatment of carcinoma of the penis. J Urol. 1989;142(6):1478–82.
McDougal WS. Carcinoma of the penis: improved survival by early regional lymphadenectomy based on the histological grade and depth of invasion of the primary lesion. J Urol. 1995;154(4):1364–6.
Chaux A, Reuter V, Lezcano C, Velazquez EF, Torres J, Cubilla AL. Comparison of morphologic features and outcome of resected recurrent and nonrecurrent squamous cell carcinoma of the penis: a study of 81 cases. Am J Surg Pathol. 2009;33(9):1299–306.
Chaux A, Torres J, Pfannl R, Barreto J, Rodriguez I, Velazquez EF, Cubilla AL. Histologic grade in penile squamous cell carcinoma: visual estimation versus digital measurement of proportions of grades, adverse prognosis with any proportion of grade 3 and correlation of a Gleason-like system with nodal metastasis. Am J Surg Pathol. 2009;33(7):1049–57.
Lopes A, Hidalgo GS, Kowalski LP, Torloni H, Rossi BM, Fonseca FP. Prognostic factors in carcinoma of the penis: multivariate analysis of 145 patients treated with amputation and lymphadenectomy. J Urol. 1996;156(5):1637–42.
Slaton JW, Morgenstern N, Levy DA, Santos Jr MW, Tamboli P, Ro JY, Ayala AG, Pettaway CA. Tumor stage, vascular invasion and the percentage of poorly differentiated cancer: independent prognosticators for inguinal lymph node metastasis in penile squamous cancer. J Urol. 2001;165(4):1138–42.
Ficarra V, Zattoni F, Cunico SC, Galetti TP, Luciani L, Fandella A, Guazzieri S, Maruzzi D, Sava T, Siracusano S, Pilloni S, Tasca A, Martignoni G, Gardiman M, Tardanico R, Zambolin T, Cisternino A, Artibani W, Gruppo Uro-Oncologico del Nord Est (Northeast Uro-Oncological Group) Penile Cancer Project. Lymphatic and vascular embolizations are independent predictive variables of inguinal lymph node involvement in patients with squamous cell carcinoma of the penis: Gruppo Uro-Oncologico del Nord Est (Northeast Uro-Oncological Group) Penile Cancer data base data. Cancer. 2005;103(12):2507–16.
Solsona E, Iborra I, Ricós JV, Monrós JL, Dumont R, Casanova J, Calabuig C. Corpus cavernosum invasion and tumor grade in the prediction of lymph node condition in penile carcinoma. Eur Urol. 1992;22(2):115–8.
Solsona E, Iborra I, Rubio J, Casanova JL, Ricós JV, Calabuig C. Prospective validation of the association of local tumor stage and grade as a predictive factor for occult lymph node micrometastasis in patients with penile carcinoma and clinically negative inguinal lymph nodes. J Urol. 2001;165(5):1506–9.
Solsona E, Algaba F, Horenblas S, Pizzocaro G, Windahl T, European Association of Urology. EAU guidelines on penile cancer. Eur Urol. 2004;46(1):1–8.
Novara G, Artibani W, Cunico SC, De Giorgi G, Gardiman M, Martignoni G, Siracusano S, Tardanico R, Zattoni F, Ficarra V, GUONE Penile Cancer Project. How accurately do Solsona and European Association of Urology risk groups predict for risk of lymph node metastases in patients with squamous cell carcinoma of the penis? Urology. 2008;71(2):328–33.
Ficarra V, Novara G, Boscolo-Berto R, Artibani W, Kattan MW. How accurate are present risk group assignment tools in penile cancer? World J Urol. 2009;27(2):155–60.
Kattan MW. When and how to use informatics tools in caring for urologic patients. Nat Clin Pract Urol. 2005;2(4):183–90.
Chaux A, Caballero C, Soares F, Guimarães GC, Cunha IW, Reuter V, Barreto J, Rodríguez I, Cubilla AL. The prognostic index: a useful pathologic guide for prediction of nodal metastases and survival in penile squamous cell carcinoma. Am J Surg Pathol. 2009;33(7):1049–57.
Ficarra V, Zattoni F, Artibani W, Fandella A, Martignoni G, Novara G, Galetti TP, Zambolin T, Kattan MW, G.U.O.N.E. Penile Cancer Project Members. Nomogram predictive of pathological inguinal lymph node involvement in patients with squamous cell carcinoma of the penis. J Urol. 2006;175(5):1700–4.
Zhu Y, Zhang HL, Yao XD, Zhang SL, Dai B, Shen YJ, Ye DW. Development and evaluation of a nomogram to predict inguinal lymph node metastasis in patients with penile cancer and clinically negative lymph nodes. J Urol. 2010;184(2):539–45.
Srinivas V, Morse MJ, Herr HW, Sogani PC, Whitmore Jr WF. Penile cancer: relation of extent of nodal metastasis to survival. J Urol. 1987;137(5):880–2.
Ornellas AA, Seixas AL, de Moraes JR. Analyses of 200 lymphadenectomies in patients with penile carcinoma. J Urol. 1991;146(2):330–2.
Pow-Sang JE, Benavente V, Pow-Sang JM, Pow-Sang M. Bilateral ilioinguinal lymph node dissection in the management of cancer of the penis. Semin Surg Oncol. 1990;6(4):241–2.
Ravi R. Correlation between the extent of nodal involvement and survival following groin dissection for carcinoma of the penis. Br J Urol. 1993;72(5 Pt 2):817–9.
Kulkarni JN, Kamat MR. Prophylactic bilateral groin node dissection versus prophylactic radiotherapy and surveillance in patients with N0 and N1-2A carcinoma of the penis. Eur Urol. 1994;26(2):123–8.
Brkovic D, Kälble T, Dörsam J, Pomer S, Lötzerich C, Banafsche R, Riedasch G, Staehler G. Surgical treatment of invasive penile cancer–the Heidelberg experience from 1968 to 1994. Eur Urol. 1997;31(3):339–42.
Hegarty PK, Kayes O, Freeman A, Christopher N, Ralph DJ, Minhas S. A prospective study of 100 cases of penile cancer managed according to European Association of Urology guidelines. BJU Int. 2006;98(3):526–31.
Novara G, Galfano A, De Marco V, Artibani W, Ficarra V. Prognostic factors in squamous cell carcinoma of the penis. Nat Clin Pract Urol. 2007;4(3):140–6.
Pandey D, Mahajan V, Kannan RR. Prognostic factors in node-positive carcinoma of the penis. J Surg Oncol. 2006;93(2):133–8.
Ornellas AA, Nóbrega BL, Wei Kin Chin E, Wisnescky A, da Silva PC, de Santos Schwindt AB. Prognostic factors in invasive squamous cell carcinoma of the penis: analysis of 196 patients treated at the Brazilian National Cancer Institute. J Urol. 2008;180(4):1354–9.
Zhu Y, Ye DW, Yao XD, Zhang SL, Dai B, Zhang HL. New N staging system of penile cancer provides a better reflection of prognosis. J Urol. 2011;186(2):518–23.
Chaux A, Cubilla AL. Stratification systems as prognostic tools for defining risk of lymph node metastasis in penile squamous cell carcinomas. Semin Diagn Pathol. 2012;29(2):83.
Svatek RS, Munsell M, Kincaid JM, et al. Association between lymph node density and disease specific survival in patients with penile cancer. J Urol. 2009;182:272.
Zhu Y, Ye D-w. Lymph node metastases and prognosis in penile cancer. Chin J Cancer Res. 2012;24(2):90–6.
Leijte JA, Gallee M, Antonini N, Horenblas S. Evaluation of current TNM classification of penile carcinoma. J Urol. 2008;180(3):933–8.
Zhu Y, Zhang SL, Ye DW, et al. Predicting pelvic lymph node metastases in penile cancer patients: a comparison of computed tomography, Cloquet’s node, and disease burden of inguinal lymph nodes. Onkologie. 2008;31:37.
Graafland NM, Moonen LM, van Boven HH, et al. Prognostic significance of extranodal extension in patients with pathological node positive penile carcinoma. J Urol. 2010;184:1347.
Pagliaro LC, Williams DL, Daliani D, Williams MB, Osai W, Kincaid M, Wen S, Thall PF, Pettaway CA. Neoadjuvant paclitaxel, ifosfamide, and cisplatin chemotherapy for metastatic penile cancer: a phase II study. J Clin Oncol. 2010;28(24):3851–7.
Kattan MW, Ficarra V, Artibani W, Cunico SC, Fandella A, Martignoni G, Novara G, Galetti TP, Zattoni F, GUONE Penile Cancer Project Members. Nomogram predictive of cancer specific survival in patients undergoing partial or total amputation for squamous cell carcinoma of the penis. J Urol. 2006;175(6):2103–8.
Zini L, Cloutier V, Isbarn H, Perrotte P, Capitanio U, Jeldres C, Shariat SF, Saad F, Arjane P, Duclos A, Lattouf JB, Montorsi F, Karakiewicz PL. A simple and accurate model for prediction of cancer-specific mortality in patients treated with surgery for primary penile squamous cell carcinoma. Clin Cancer Res. 2009;15(3):1013–8.
Thuret R, Sun M, Abdollah F, Budaus L, Lughezzani G, Liberman D, Morgan M, Johal R, Jeldres C, Latour M, Shariat SF, Iborra F, Guiter J, Patard JJ, Perrotte P, Karakiewicz PI. Tumor grade improves the prognostic ability of American Joint Committee on Cancer stage in patients with penile carcinoma. J Urol. 2011;185(2):501–7.
Thuret R, Sun M, Abdollah F, Schmitges J, Shariat SF, Iborra F, Guiter J, Patard JJ, Perrotte P, Karakiewicz PI. Conditional survival predictions after surgery for patients with penile carcinoma. Cancer. 2011;117(16):3723–30.
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Appendix I
Appendix I
Instructions for Physicians: Locate the tumor thickness on the tumor thickness axis. Draw a line straight upward to the Points axis to determine the number of points received for tumor thickness. Repeat this process for the remaining axes, each time drawing straight upward to the Points axis. Sum the points achieved for each predictor and locate the sum on the Total Points axis. Draw a line straight down to find the 5-year cancer-specific survival of the patient.
Instructions to Patient: “Mr. X, if we had 100 men exactly like you, we would expect the predicted percentage from the nomogram to be free of disease-specific death in 5 years, assuming no one died of another cause.”
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Slaton, J. (2014). Prognostic Factors. In: Culkin, D. (eds) Management of Penile Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0461-7_5
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DOI: https://doi.org/10.1007/978-1-4939-0461-7_5
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