Abstract
The hyalinizing trabecular tumor—or “adenoma,” as it originally was described by Carney in 1987, can mimic medullary and papillary thyroid carcinoma. This unique tumor occurs more commonly in females and over a broad age range (27–72 years; mean, 46 years). These tumors originally were diagnosed as carcinoma, adenoma, paraganglioma, or “indeterminate.” None of the tumors in the original series metastasized during 10 years of follow-up. Additional case reports and small series followed, with a few tumors showing capsular or vascular invasion. These tumors generally are not associated with BRAF or RAS mutations, but RET alterations have been reported. Whether this is sufficient for these tumors to be regarded as variants of papillary thyroid carcinoma (PTC) has been controversial, as RET/PTC rearrangements are not specific for PTC. Some of the hyalinizing trabecular tumors with RET rearrangements were from thyroids that also had PTCs. Also, some have reported RET/PTC rearrangements in Hashimoto thyroiditis, although this is not corroborated by others.
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References
Carney JA, Ryan J, Goellner JR. Hyalinizing trabecular adenoma of the thyroid gland. Am J Surg Pathol. 1987;11(8):583–91.
Katoh R, Jasani B, Williams ED. Hyalinizing trabecular adenoma of the thyroid. A report of three cases with immunohistochemical and ultrastructural studies. Histopathology. 1989;15(3):211–24.
Molberg K, Albores-Saavedra J. Hyalinizing trabecular carcinoma of the thyroid gland. Hum Pathol. 1994;25(2):192–7.
Cheung CC, et al. Hyalinizing trabecular tumor of the thyroid: a variant of papillary carcinoma proved by molecular genetics. Am J Surg Pathol. 2000;24(12):1622–6.
Papotti M, et al. RET/PTC activation in hyalinizing trabecular tumors of the thyroid. Am J Surg Pathol. 2000;24(12):1615–21.
Salvatore G, et al. Molecular profile of hyalinizing trabecular tumours of the thyroid: high prevalence of RET/PTC rearrangements and absence of B-raf and N-ras point mutations. Eur J Cancer. 2005;41(5):816–21.
Lloyd RV. Hyalinizing trabecular tumors of the thyroid: a variant of papillary carcinoma? Adv Anat Pathol. 2002;9(1):7–11.
Sheils O, et al. RET/PTC rearrangements in Hashimoto’s thyroiditis. Int J Surg Pathol. 2002;10(2):167–8; author reply 168–9.
Wirtschafter A, et al. Expression of the RET/PTC fusion gene as a marker for papillary carcinoma in Hashimoto’s thyroiditis. Laryngoscope. 1997;107(1):95–100.
Nikiforova MN, et al. Prevalence of RET/PTC rearrangements in Hashimoto’s thyroiditis and papillary thyroid carcinomas. Int J Surg Pathol. 2002;10(1):15–22.
Carney JA, et al. Hyalinizing trabecular tumors of the thyroid gland are almost all benign. Am J Surg Pathol. 2008;32(12):1877–89.
Nose V, Volante M, Papotti M. Hyalinizing trabecular tumor of the thyroid: an update. Endocr Pathol. 2008;19(1):1–8.
Hirokawa M, Carney JA. Cell membrane and cytoplasmic staining for MIB-1 in hyalinizing trabecular adenoma of the thyroid gland. Am J Surg Pathol. 2000;24(4):575–8.
Galgano MT, Mills SE, Stelow EB. Hyalinizing trabecular adenoma of the thyroid revisited: a histologic and immunohistochemical study of thyroid lesions with prominent trabecular architecture and sclerosis. Am J Surg Pathol. 2006;30(10):1269–73.
Blumenfeld W, Nair R, Mir R. Diagnostic significance of papillary structures and intranuclear inclusions in Hurthle-cell neoplasms of the thyroid. Diagn Cytopathol. 1999;20(4):185–9.
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Erickson, L.A. (2014). Hyalinizing Trabecular Tumor. In: Atlas of Endocrine Pathology. Atlas of Anatomic Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0443-3_6
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DOI: https://doi.org/10.1007/978-1-4939-0443-3_6
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