Abstract
Tumors metastatic to the adrenal gland are more common than primary adrenal tumors. Understanding the histologic spectrum of primary adrenal tumors as well as the immunophenotype enables differentiation of tumors metastatic to the adrenal gland. Adrenal cortical tumors are positive for the broad-spectrum neuroendocrine marker synaptophysin, but negative for chromogranin. This enables differentiation of adrenal cortical tumors from adrenal medullary tumors and neuroendocrine tumors metastatic to the adrenal glands. Mart-1/MelanA is very helpful in identifying adrenal cortical tumors and differentiating them from metastases. Adrenal cortical tumors show immunopositivity for Mart-1/MelanA and are negative for S100, enabling distinction from malignant melanoma.
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References
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Erickson, L.A. (2014). Metastases to the Adrenal Gland. In: Atlas of Endocrine Pathology. Atlas of Anatomic Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0443-3_29
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DOI: https://doi.org/10.1007/978-1-4939-0443-3_29
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