Age-Related Changes in Vascular Biology and Implications for Heart Failure Therapy in the Aging Population

  • Michael Sean McMurtryEmail author


Heart failure is a common cardiovascular disorder that is increasingly prevalent in aging Western populations. While heart failure is more prevalent in elderly populations due in part to increased prevalence of risk factors for heart failure, aging itself can alter the structure and function of the cardiovascular system, including the arterial tree as well as the myocardium, and contribute to heart failure independent of comorbidities or other exposures. This review will discuss the impact of age on the epidemiology of heart failure, age-related changes of the arterial tree and myocardium, age-associated changes in hemodynamics like arterial stiffness and their contribution to heart failure even in the presence of preserved left ventricular function, and putative molecular mechanism of aging in the cardiovascular system and discuss briefly implications of these observations for future efforts to prevent and to treat heart failure in elderly populations.


Heart Failure Arterial Stiffness Arterial Tree Left Ventricular Systolic Dysfunction Aortic Stiffness 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Dr. O Baclic (Chronic Disease Management Division, PHAC), L Bartlett (The First Nations Information Governance Committee), T Bhatia (Data Coordination and Access Program, PHAC), Dr. M de Groh (Chronic Disease Prevention Division, PHAC), B Foster (Chronic Disease Prevention Division, PHAC), J Francis (Chronic Disease Evidence and Risk Assessment Division, PHAC), M-F Giguere (Strategic Policy Directorate, PHAC), C Gilbert (Chronic Disease Surveillance Division, PHAC), E Jones-McLean (Chronic Disease Prevention Division, PHAC), Dr. J Kahn (Portal Communications), K Lynch, Q Li (Statistics Canada), B Maga (Maga Policy Consultants Ltd.), J MacInnes (Chronic Disease Prevention Division, PHAC), N Martin (Neasa Martin & Associates), Dr. H Morrison (Chronic Disease Science Office, PHAC), B Power (Chronic Disease Management Division, PHAC), R Przybysz (Canadian Institute for Health Information), O Randell (Inuit Tapiriit Kanatami), H Roberge (Strategic Policy Directorate, PHAC), K Roberts (Chronic Disease Surveillance Division, PHAC), P Sales (Douglas Consulting), R Semenciw (Chronic Disease Surveillance Division, PHAC), T Simpson (Chronic Disease Prevention Division, PHAC), J Snider (Tobacco Control Programme, Health Canada), R Susanto (Statistics Canada), S Tanguay (Strategic Policy Directorate, PHAC), E Vanden (Chronic Disease Management Division, PHAC), R Walker (University of Calgary), and F Wang (Chronic Disease Evidence and Risk Assessment Division, PHAC).

We acknowledge Dr. RA Hegele and RL Pollex in the writing of Chapter Three – The Genetic Epidemiology of CVD.

We acknowledge Dr. MP Lindsay, Dr. M Hill, Dr. MK Kapral, Dr. M Sharma, Dr. S Phillips, and Dr. A Hakim, on behalf of the Canadian Stroke Network (, in the writing of Chapter Five – Stroke.”


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Division of Cardiology, Department of MedicineUniversity of AlbertaEdmontonCanada

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