Aging-Related Changes in Cellular and Molecular Mechanisms of Postinfarction Remodeling: Implications for Heart Failure Therapy

  • Henry Han-Jen Shih
  • Andrew J. BoyleEmail author


The normal course of aging is well known to result in decreased cardiac function; decreased capacity to tolerate insults, such as myocardial infarction (MI); and a higher prevalence of pathological remodeling post-MI. Recent progress in aging biology has allowed investigators to understand the effect of aging from the molecular, organelle, and cellular levels that ultimately result in organ dysfunction. In this chapter, we will review the natural course of cellular and molecular changes in the heart that predispose an aging heart toward adverse remodeling, the age-related differences in the postinfarction remodeling process, the clinical implications of aging and postinfarction remodeling, and future targets for heart failure therapy in the aged population.


Stem Cell Stem Cell Therapy Cardiomyocyte Apoptosis Autophagic Cell Death Secretory Leukocyte Protease Inhibitor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.School of Medicine, Tufts UniversityBostonUSA
  2. 2.Department of CardiologyUniversity of Newcastle, John Hunter HospitalNewcastleAustralia

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