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Aging-Related Changes in Cellular and Molecular Mechanisms of Postinfarction Remodeling: Implications for Heart Failure Therapy

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Aging and Heart Failure

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Abstract

The normal course of aging is well known to result in decreased cardiac function; decreased capacity to tolerate insults, such as myocardial infarction (MI); and a higher prevalence of pathological remodeling post-MI. Recent progress in aging biology has allowed investigators to understand the effect of aging from the molecular, organelle, and cellular levels that ultimately result in organ dysfunction. In this chapter, we will review the natural course of cellular and molecular changes in the heart that predispose an aging heart toward adverse remodeling, the age-related differences in the postinfarction remodeling process, the clinical implications of aging and postinfarction remodeling, and future targets for heart failure therapy in the aged population.

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Author information

Authors and Affiliations

  1. School of Medicine, Tufts University, 145 Harrison Avenue, Boston, MA, 02111, USA

    Henry Han-Jen Shih MD

  2. Department of Cardiology, University of Newcastle, John Hunter Hospital, 2 Lookout Road, New Lambton Heights, Newcastle, NSW, 2305, Australia

    Andrew J. Boyle MBBS, PhD

Authors
  1. Henry Han-Jen Shih MD
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  2. Andrew J. Boyle MBBS, PhD
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Corresponding author

Correspondence to Andrew J. Boyle MBBS, PhD .

Editor information

Editors and Affiliations

  1. Division of Cardiology, Department of Medicine, Mazankowski Alberta Heart Institute, University of Alberta and Hospitals, Edmonton, Alberta, Canada

    Bodh I. Jugdutt

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Shih, H.HJ., Boyle, A.J. (2014). Aging-Related Changes in Cellular and Molecular Mechanisms of Postinfarction Remodeling: Implications for Heart Failure Therapy. In: Jugdutt, B. (eds) Aging and Heart Failure. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0268-2_29

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  • DOI: https://doi.org/10.1007/978-1-4939-0268-2_29

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