Integrins: Implications for Aging in Heart Failure Therapy

  • Laura L. Daniel
  • William L. Joyner
  • Mahipal Singh
  • Krishna SinghEmail author


Integrins are a large family of heterodimeric transmembrane receptors that attach cells to extracellular matrix proteins of the basement membrane. They are bidirectional signaling molecules composed of noncovalently associated α and β subunits. They can form over 24 pairs in mammalian cells creating a wide range of ligand specificity for binding to different components of the extracellular matrix. Integrin expression changes depending on the type of cell, its developmental stage, or the pathological status. There is also an age-associated change in integrin expression which may, at least in part, be responsible for the high prevalence of age-associated disorders. The focus of this chapter is to discuss (1) general structure and function of integrins, (2) expression of integrins in the heart, (3) change in the expression of integrins in the heart during aging, (4) their role in regulation of the remodeling process of the heart, and (5) their therapeutic potential for treatment of heart failure.


Focal Adhesion Kinase Cardiac Myocytes Cardiac Fibroblast Integrin Expression Integrin Subunit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work is supported by the National Institutes of Health (Grant numbers HL-091405 and HL-092459 to KS) and a Merit Review award (number BX000640 to KS) from the Biomedical Laboratory Research and Development Service of the VA Office of Research and Development.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Laura L. Daniel
    • 1
  • William L. Joyner
    • 1
  • Mahipal Singh
    • 1
  • Krishna Singh
    • 2
    Email author
  1. 1.Department of Biomedical SciencesEast Tennessee State UniversityJohnson CityUSA
  2. 2.Department of Biomedical SciencesEast Tennessee State UniversityJohnson CityUSA

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