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Aging-Related Changes in Extracellular Matrix: Implications for Ventricular Remodeling Following Myocardial Infarction

  • Nguyen T. Nguyen
  • Andriy Yabluchanskiy
  • Lisandra E. de Castro Brás
  • Yu-Fang Jin
  • Merry L. Lindsey
Chapter

Abstract

In humans, age-related changes in the myocardium include increases in vascular intimal thickness, vascular stiffness, left ventricle (LV) wall thickness, and left atrial size. These changes in tissue structure and function are the result of altered expression profiles of extracellular matrix (ECM) components. While aging itself is not a pathological condition, this resetting of homeostasis sets up the LV to respond poorly to stress. As a reflection of this, morbidity and mortality rates after myocardial infarction (MI) strongly correlate with advancing age. To date, targeting specific ECM components for therapeutic purposes has only been achieved by indirect mechanisms. This book chapter summarizes the current knowledge of ECM remodeling during aging and MI, focusing on mechanistic insights that may reveal avenues to explore for therapeutic potential.

Keywords

Vascular Endothelial Growth Factor Left Ventricle Aldosterone Antagonist Infarct Region Left Ventricle Wall 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviation

ECM

Extracellular matrix

LV

Left ventricle

MMP

Matrix metalloproteinase

MI

Myocardial infarction

OPN

Osteopontin

SPARC

Secreted protein acidic and rich in cysteine

TSP

Thrombospondin

TIMP

Tissue inhibitors of metalloproteinase

TGF

Transforming growth factor

VEGF

Vascular endothelia growth factor

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Nguyen T. Nguyen
    • 1
  • Andriy Yabluchanskiy
    • 2
  • Lisandra E. de Castro Brás
    • 2
  • Yu-Fang Jin
    • 1
  • Merry L. Lindsey
    • 2
    • 3
  1. 1.San Antonio Cardiovascular Proteomics Center, Department of Electrical and Computer EngineeringUniversity of Texas at San AntonioSan AntonioUSA
  2. 2.San Antonio Cardiovascular Proteomics Center and Mississippi Center for Heart Research, Department of Physiology and BiophysicsUniversity of MississippiJacksonUSA
  3. 3.Department of Physiology and BiophysicsUniversity of Mississippi Medical CenterJacksonUSA

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