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Role of Resistin in Heart Failure in the Elderly

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Aging and Heart Failure

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Abstract

Resistin is derived mainly from fat tissue in rodents, and serum levels are elevated in animal models of obesity and insulin resistance. Recent clinical studies have demonstrated that circulating resistin is associated with inflammation, coronary atherosclerosis, renal dysfunction, adverse prognosis in patients with atherothrombotic ischemic stroke, and heart failure. In the population-based observational study, increased circulating levels of resistin are associated with incidence of new-onset heart failure, even after accounting for prevalent coronary heart disease, obesity, insulin resistance, and inflammation. In the elderly, incident heart failure rates (per 1,000 person-years) elevate with increasing baseline resistin concentrations. In addition, resistin is strongly associated with risk for incident heart failure in Cox proportional hazard models controlling for clinical variables, inflammatory biomarkers, and measures of adiposity.

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Authors and Affiliations

  1. Department of Cardiology and Hematology, Fukushima Medical University, 1 Hikarigaoka, Fukushima, Japan

    Yasuchika Takeishi MD, PhD

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  1. Yasuchika Takeishi MD, PhD
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Correspondence to Yasuchika Takeishi MD, PhD .

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Editors and Affiliations

  1. Division of Cardiology, Department of Medicine, Mazankowski Alberta Heart Institute, University of Alberta and Hospitals, Edmonton, Alberta, Canada

    Bodh I. Jugdutt

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Takeishi, Y. (2014). Role of Resistin in Heart Failure in the Elderly. In: Jugdutt, B. (eds) Aging and Heart Failure. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0268-2_16

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  • DOI: https://doi.org/10.1007/978-1-4939-0268-2_16

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-0267-5

  • Online ISBN: 978-1-4939-0268-2

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