Biomarkers and Optimal Management of Heart Failure in the Aging Population

  • Hanna K. GagginEmail author
  • James L. JanuzziJr.


The incidence of heart failure (HF) increases with advancing age with a lifetime risk for the diagnosis of 20 %. There are physiological changes that predispose the elderly to developing HF and small insults may rapidly precipitate decompensation of symptoms. There are special challenges in diagnosing and managing elderly patients with HF, challenges that biomarkers can help mitigate. Natriuretic peptides such as B-type natriuretic peptide and N-terminal proBNP are established biomarkers that have been proven to accurately diagnose and prognosticate HF. There are additional promising novel biomarkers that may be of use.


Heart Failure Natriuretic Peptide Atrial Natriuretic Peptide Pulmonary Capillary Wedge Pressure Acute Heart Failure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



American College of Cardiology


Angiotensin converting enzyme


Acute Decompensated Heart Failure National Registry


American Heart Association


Atrial natriuretic peptide


Angiotensin II receptor blockers


Biomarkers in Acute Heart Failure


The NT-proBNP-Assisted Treatment to Lessen Serial Cardiac Readmissions and Death


B-type natriuretic peptide


Cardiovascular Health Study


Growth differentiation factor


Heart failure


Heart failure with preserved ejection fraction


Highly sensitive troponin T


Left ventricular systolic dysfunction


Mid-regional pro adrenomedullin


Mid-regional pro atrial natriuretic peptide


Natriuretic peptide(s)


Amino-terminal B-type natriuretic peptide


Pulmonary capillary wedge pressure


ProBNP Investigation of Dyspnea in the Emergency Department


ProBNP Outpatient Tailored Chronic Heart Failure Therapy


Rapid Emergency Department Heart Failure Outpatient Trial


Soluble ST2


Trial of Intensified versus Standard Medical therapy in Elderly Patients with Congestive HF


Valsartan Heart Failure


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Cardiology Division, Department of MedicineMassachusetts General HospitalBostonUSA
  2. 2.Cardiology Division, Department of MedicineBostonUSA

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