Abstract
Animal data have shown that botulinum neurotoxins (BoNTs) inhibit the release of pain neurotransmitters/neuromodulators (glutamate, substance P, calcitonin-gene-related peptide) and pro-inflammatory agents (prostaglandins, bradykinin, histamine) from peripheral nerve endings and sensory ganglia and reduce the phenomena of peripheral and central sensitization, major factors for pain chronicity. A review of class I and II studies (double blind, placebo controlled) using the criteria set forward by the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology shows different levels of efficacy for a large number of human pain disorders: There exists level A evidence (two or more class I studies—established efficacy) for pain of cervical dystonia, chronic migraine and chronic lateral epicondylitis and level-B evidence (one class I or two class II studies—probably effective) for postherpetic and posttraumatic neuralgia, pain of plantar fasciitis, piriformis syndrome and pain in total knee arthroplasty. Level C evidence (one class II study—possibly effective) denotes allodynia of diabetic neuropathy, chronic low back pain, painful knee osteoarthritis, anterior knee pain with vastus lateralis imbalance, pelvic pain, postoperative pain in children with cerebral palsy after adductor hip release surgery, postoperative pain after mastectomy and sphincter spasms and pain after hemorrhoidectomy. The myofascial pain syndrome and chronic daily headaches have level U evidence (efficacy not proven due to controversial results). Results of BoNT treatment trials in episodic migraine and chronic tension headaches justify level A evidence for treatment failure. The end of each assessed category includes a medical comment and suggestions for improvement of future studies. For certain pain syndromes, figures are provided to illustrate the suggested number and site of injections and the appropriate doses.
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References
Jankovic J, Albanese A, Atassi Z, Dolly O, Hallett M, May N (eds) (2008) Botulinum toxin: therapeutic clinical practice and science. Saunders, New York
Blasi J, Chapman ER, Link E, Binz T, Yamasaki S, De Camilli P, Südhof TC, Niemann H, Jahn R (1993) Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25. Nature 365:160–163
Chaddock JA, Purkiss JR, Alexander FC, Doward S, Fooks SJ, Friis LM, Hall YH, Kirby ER, Leeds N, Moulsdale HJ, Dickenson A, Green GM, Rahman W, Suzuki R, Duggan MJ, Quinn CP, Shone CC, Foster KA (2004) Retargeted clostridial endopeptidases: inhibition of nociceptive neurotransmitter release in vitro, and antinociceptive activity in in vivo models of pain. Mov Disord 19(Suppl 8):S42–47
French J, Gronseth G (2008) Lost in a jungle of evidence: we need a compass. Neurology 71:1634–1638
Gazerani P, Au S, Dong X, Kumar U, Arendt-Nielsen L, Cairns BE (2010) Botulinum neurotoxin type A (BoNTA) decreases the mechanical sensitivity of nociceptors and inhibits neurogenic vasodilation in a craniofacial muscle targeted for migraine prophylaxis. Pain 151:606–616
Aoki KR (2005) Review of a proposed mechanism for the antinociceptive action of botulinum toxin Type A. Neurotoxicology 26:785–793
Roberts WJ (1986) A hypothesis on the physiological basis for causalgia and related pains. Pain 24:297–311
Lawrence GW, Aoki KR, Dolly JO (2010) Excitatory cholinergic and purinergic signaling in bladder are equally susceptible to botulinum neurotoxin A consistent with co-release of transmitters from efferent fibers. J Pharmacol Exp Ther 334:1080–1086
Osikowicz M, Mika J, Makuch W, Przewlocka B (2008) Glutamate receptor ligands attenuate allodynia and hyperalgesia and potentiate morphine effects in a mouse model of neuropathic pain. Pain 139:117–126
Cui M, Khanijou S, Rubino J, Aoki KR (2004) Subcutaneous administration of botulinum toxin A reduces formalin-induced pain. Pain 107:125–133
Marinelli S, Luvisetto S, Cobianchi S, Makuch W, Obara I, Mezzaroma E, Caruso M, Straface E, Przewlocka B, Pavone F (2010) Botulinum neurotoxin type A counteracts neuropathic pain and facilitates functional recovery after peripheral nerve injury in animal models. Neuroscience 24(171):316–328
Dolly JO, Aoki KR (2006) The structure and mode of action of different botulinum toxins. Eur J Neurology 13:1–9
Meng J, Wang J, Lawrence G, Dolly JO (2007) Synaptobrevin I mediates exocytosis of CGRP from sensory neurons and inhibition by botulinum toxins reflects their anti-nociceptive potential. J Cell Sci 120:2864–2874
Lucioni A, Bales GT, Lotan TL, McGehee DS, Cook SP, Rapp DE (2008) Botulinum toxin type A inhibits sensory neuropeptide release in rat bladder models of acute injury and chronic inflammation. BJU Int 101:366–370
Namazi H (2008) Intravesical botulinum toxin A injections plus hydrodistension can reduce nerve growth factor production and control bladder pain in interstitial cystitis: a molecular mechanism. Urology 72:463–464
Chuang YC, Yoshimura N, Huang CC, Wu M, Chiang PH, Chancellor MB (2008) Intraprostatic botulinum toxin A injection inhibits cyclooxygenase-2 expression and suppresses prostatic pain on capsaicin induced prostatitis model in rat. J Urol 180:742–748
Rand MJ, Whaler BC (1965) Impairment of sympathetic transmission by botulinum toxin. Nature 206:588–591
Filippi GM, Errico P, Santarelli R, Bagolini B, Manni E (1993) Botulinum A toxin effects on rat jaw muscle spindles. Acta Otolarynol 113:400–404
Wiegand H, Erdmann G, Welhoner HH (1976) 125I-labelled botulinum A neurotoxin: pharmacokinetics in cats after intramuscular injection. Naunyn Schmiedebergs Arch Pharmacol 292:161–165
Favre-Guilmard C, Auguet M, Chabrier PE (2009) Different antinociceptive effects of botulinum toxin type A in inflammatory and peripheral polyneuropathic rat models. Eur J Pharmacol 617:48–53
Bach-Rojecky L, Salković-Petrisić M, Lacković Z (2010) Botulinum toxin type A reduces pain supersensitivity in experimental diabetic neuropathy: bilateral effect after unilateral injection. Eur J Pharmacol 633:10–14
Min-chul S, Watika M, Montomura T, Torri Y, Akaike N (2010) Femtomoar concentratiosn of A type botuinum toxin inhibit membrane NA channels in rat central and peripheral neurons. Poster # 40 presented to IBRCC meeting in Atlanta- October
Fischer TZ, Waxman SG (2010) Familial pain syndromes from mutations of the NaV1.7 sodium channel. Ann N Y Acad Sci 1184:196–207
Verderio C, Grumelli C, Raiteri L, Coco S, Paluzzi S, Caccin P, Rossetto O, Bonanno G, Montecucco C, Matteoli M, Verderio C, Grumelli C, Raiteri L, Coco S, Paluzzi S, Caccin P, Rossetto O, Bonanno G, Montecucco C, Matteoli M (2007) Traffic of botulinum toxins A and E in excitatory and inhibitory neurons. Traffic 8:142–153
Gronseth G, French J (2008) Practice parameters and technology assessments: what they are, what they are not, and why you should care. Neurology 71:1639–1643
Comella CL (2008) The treatment of cervical dystonia with botulinum toxins. J Neural Transmission 115:379–583
Greene P, Kang U, Fahn S, Brin M, Moskowitz C, Flaster E (1990) Double-blind, placebo controlled trial of botulinum toxin injections for the treatment of spasmodic torticollis. Neurology 40:1213–1218
Poewe W, Deuschl G, Nebe A, Feifel E, Wissel J, Benecke R, Kessler KR, eballos-Baumann AO, Ohly A, Oertel W, Kunig G (1998) What is the optimum dose of botulinum toxin A in the treatment of cervical dystonia? Result of double-blind, placebo controlled, dose ranging study using Dysport. German dystonia study group. J Neurol Neurosurg Psychiatry 64:13–17
Truong D, Duane DD, Jankovic J, Singer C, Seeberger LC, Comella CL, Lew MF, Rodontzky RL, Danisi FO, Sutton JP, Charles PD, Hauser RA, Sheean GL (2005) Efficacy and safety of botulinum A toxin (Dysport) in cervical dystonia: results of the first US randomized, double-blined, placebo-controlled study. Mov Disord 20:783–791
Truong D, Brodsky M, Lew M, Brashear A, Jankovic J, Molho E, Orlova O, Timerbaeva S (2010) Global dysport cervical dystonia study group. Long-term efficacy and safety of botulinum toxin type A (Dysport) in cervical dystonia. Parkinsonism Relat Disord 16:316–323
Lew MF, Adornato BT, Duane DD, Dykstra DD, Factor SA, Massey JM, Brin MF, Jankovic J, Rodintzky RL, Singer C, Swenson MR, Tarsy D, Murry JJ, Koller M, Wallace JD (1997) Btulinum toxin type B: a double-blind, placebo-controlled safety and efficacy study in cervical dystonia. Neurology 49:701–707
Brin M, F, Lew MF, Adler CH, Comella CL, Factor SA, Jankovic J, O’Brien C, Murry JJ, Wallace JD, Willmer-Hulme A, Koller M (1999) Safety and efficacy of NeuroBloc (botulinum toxin type B) in type-A resistant cervical dystonia. Neurology 53:1431–1438
Brashear A, Lew MF, Dystra DD, Comella CL, Factor SA, Rodnitzki RL, Trosch I, Singer C, Brin MF, Murry JJ, Wallace JD, Willmer-Hulme A, Koller M (1999) Safety and efficacy of Neurobloc (Botulinum toxin type B) in type-A responsive cervical dystonia. Neurology 53:1439–1446
Lew MF, Chinnapongse R, Zhang Y, Corliss M (2010) RimabotulinumtoxinB pain associated with cervical dystonia: results of placebo and comparator-controlled studies. Int J Neurosci 120:298–300
Brans JW, Linderboom R, Snoek JW, Zwartz MJ, van weerden TW, Brunt ER, van Hilten JJ, van der Kamp W, Prins MH, Speelman JD (1996) Botulinum toxin versus trihexyphenidyl in cervical dystonia: a prospective, randomized, double-blind trial. Neurology 46:1066–1072
Comella CL, Jankovic J, Shannon KM, Tsui J, Swenson M, Leurgans S, Fan W (2005) Dystonia study group. Comparison of botulinum toxin serotypes A and B for the treatment of cervical dystonia. Neurology 65:1423–1429
Pappert EJ, Germanson T (2008) Myobloc/Neurobloc European cervical dystonia study group. Botulinum toxin type B vs. type A in toxin-naïve patients with cervical dystonia: randomized, double-blind, non-inferiority trial. Mov Disord 23:510–517
Benecke R, Jost WH, Kanovsky P, Ruzicka E, Comes G, Grafe S (2005) A new botulinum toxin type A free of complexing proteins for treatment of cervical dystonia. Neurology 64:1949–1951
Odergren T, Hajaltason H, Kaakola S, Solders G, Hanko J, Fehling C, Marttila RJ, Lundh H, Gedin S, Westergern I, Richardson A, Dott C, Cohen H (1998) A double blind, randomized, parallel group study to investigate the dose equivalance of Dysport and Onabotulinum toxin A in the treatment of cervical dystonia. J Neurol Neurosurg Psychiatry 64:6–12
Quagliato EM, Carelli EF, Viana MA (2010) Prospective, randomized, double-blind study, comparing botulinum toxins type A botox and prosigne for blepharospasm and hemifacial spasm treatment. Clin Neuropharmacol 33(1):27–31
Poewe W, Schelosky L, Kleedorfer B, Heinen F, Wagner M, Deusch G (1992) Treatment of spasmodic torticollis with local injections of botulinum toxin. One year follow up in 37 patients. J Neurol 239:21–25
Kessler KR, Skutta M, Benecke R (1999) Long-term treatment of cervical dystonia with botulinum toxin A: efficacy, safety and antibody frequency. German dystonia study group. J Neurol 246:265–274
Scher AI, Stewart WF, Liberman J, Lipton RB (1998) Prevalence of frequent headache in a population sample. Headache 38:497–506
Freitag FG, Diamond S, Diamond M, Urban G (2008) Botulinum toxin type A in the treatment of chronic migraine without medication overuse. Headache 48:201–209
Aurora SK, Dodick DW, Turkel CC, DeGryse RE, Silberstein SD, Lipton RB, Diener HC, Brin MF (2010) PREEMPT 1 Chronic Migraine Study Group. OnabotulinumtoxinA for treatment of chronic migraine: results from the double-blind, randomized, placebo-controlled phase of the PREEMPT 1 trial. Cephalalgia 30:793–803
Diener HC, Dodick DW, Aurora SK, Turkel CC, DeGryse RE, Lipton RB, Silberstein SD, Brin MF (2010) PREEMPT 2 Chronic Migraine Study Group. OnabotulinumtoxinA for treatment of chronic migraine: results from the double-blind, randomized, placebo-controlled phase of the PREEMPT 2 trial. Cephalalgia 30:804–814
Dodick DW, Turkel CC, DeGryse RE, Aurora SK, Silberstein SD, Lipton RB, Diener HC, Brin MF (2010) PREEMPT Chronic Migraine Study Group. OnabotulinumtoxinA for treatment of chronic migraine: pooled results from the double-blind, randomized, placebo-controlled phases of the PREEMPT clinical program. Headache 50:921–936
Wong SM, Hui AC, Tong PY, Poon DW, Yu E, Wong LK (2005) Treatment of lateral epicondylitis with botulinum toxin: a randomized, double-blind, placebo-controlled trial. Ann Intern Med 143(11):793–797
Hayton MJ, Santini AJ, Hughes PJ, Frostick SP, Trail IA, Stanley JK (2005) Botulinum toxin injection in the treatment of tennis elbow. A double-blind, randomized, controlled, pilot study. J Bone Joint Surg Am 87:503–507
Placzek R, Drescher W, Deuretzbacher G, Hempfing A, Meiss AL (2007) Treatment of chronic radial epicondylitis with botulinum toxin A. A double-blind, placebo-controlled, randomized multicenter study. J Bone Joint Surg Am 89:255–260
Espandar R, Heidari P, Rasouli MR, Saadat S, Farzan M, Rostami M, Yazdanian S, Mortazavi SM (2010) Use of anatomic measurement to guide injection of botulinum toxin for the management of chronic lateral epicondylitis: a randomized controlled trial. CMAJ 182:768–773
Argoff CE (2002) A focused review on the use of btulinum toxins for neuropathic pain. Clinical J Pain 18:S177–S181
Xiao L, Mackey S, Hui H, Xong D, Zhang Q, Zhang D (2010) Subcutaneous injection of botulinum toxin A is beneficial in postherpetic neuralgia. Pain Med 11:1827–1833
Ranoux D, Attal N, Morain F, Bouhassira D (2008) Botulinum toxin type A induces direct analgesic effects in chronic neuropathic pain. Ann Neurol 64:274–283
Babcock MS, Foster L, Pasquina P, Jabbari B (2005) Treatment of pain attributed to plantar fasciitis with botulinum toxin A: a short-term, randomized, placebo-controlled, double-blind study. Am J Phys Med Rehabil 84:649–654
Huang YC, Wei SH, Wang HK, Lieu FK (2010) Ultrasonographic guided botulinum toxin type A treatment for plantar fasciitis: an outcome-based investigation for treating pain and gait changes. J Rehabil Med 42:136–140
Childers MK, Wilson DJ, Gnatz SM, Conway RR, Sherman AK (2002) Botulinum toxin type A use in piriformis muscle syndrome: a pilot study. Am J Phys Med Rehabil 81:751–759
Fishman LM, Anderson C, Rosner B (2002) BOTOX and physical therapy in the treatment of piriformis syndrome. Am J Phys Med Rehabil 81:936–942
Brander VA, Stulberg SD, Adams AD, Harden RN, Bruehl S, Stanos SP, Houle T (2003) Predicting total knee replacement pain: a prospective, observational study. Clin Orthop Relat Res 416:416–427
Singh JA, Mahowald ML, Noorbaloochi SJ (2010) Intraarticular botulinum toxin a for refractory painful total knee arthroplasty: a randomized controlled trial. Rheumatol 37:2377–2386
Foster L, Clapp L, Erickson M, Jabbari B (2001) Botulinum toxin A and chronic low back pain: a randomized, double-blind study. Neurology 56:1290–1293
Jabbari B, Ney J, Sichani A, Monacci W, Foster L, Difazio M (2006) Treatment of refractory, chronic low back pain with botulinum neurotoxin A: an open-label, pilot study. Pain Med 7:260–264
Yuan RY, Sheu JJ, Yu JM, Chen WT, Tseng IJ, Chang HH, Hu CJ (2009) Botulinum toxin for diabetic neuropathic pain: a randomized double-blind crossover trial. Neurology 72:1473–1478
Boon AJ, Smith J, Dahm DL, Sorenson EJ, Larson DR, Fitz-Gibbon PD, Dykstra DD, Singh JA (2010) Efficacy of intra-articular botulinum toxin type A in painful knee osteoarthritis: a pilot study. PM & R 2:268–276
Singer BJ, Silbert PL, Song S, Dunne JW, Singer KP (2011) Treatment of refractory anterior knee pain using botulinum toxin type A (Dysport) injection to the distal vastus lateralis muscle: a randomised placebo controlled crossover trial. Br J Sports Med 45:640–645
Abbott JA, Jarvis SK, Lyons SD, Thomson A, Vancaille TG (2006) Botulinum toxin type A for chronic pain and pelvic floor spasm in women: a randomized controlled trial. Obstet Gynecol 108:915–923
Barwood S, Baillieu C, Boyd R, Brereton K, Low J, Nattrass G, Graham HK (2000) Analgesic effects of botulinum toxin A: a randomized, placebo-controlled clinical trial. Dev Med Child Neurol 42:116–121
Layeeque R, Hochberg J, Siegel E, Kunkel K, Kepple J, Henry-Tillman RS, Dunlap M, Seibert J, Klimberg VS (2004) Botulinum toxin infiltration for pain control after mastectomy and expander reconstruction. Ann Surg 240:608–613
Davies J, Duffy D, Boyt N, Aghahoseini A, Alexander D, Leveson S (2003) Botulinum toxin (botox) reduces pain after hemorrhoidectomy: results of a double-blind, randomized study. Dis Colon Rectum 46:1097–1102
Freund BJ, Schwartz M (2000) Treatment of whiplash associated neck pain [corrected] with botulinum toxin-A: a pilot study. J Rheumatol 27:481–484
Wheeler AH, Goolkasian P, Gretz SS (1998) A randomized, double-blind, prospective pilot study of botulinum toxin injection for refractory, unilateral, cervicothoracic, paraspinal, myofascial pain syndrome. Spine 23:1662–1666
Ferrante FM, Bearn L, Rothrock R, King L (2005) Evidence against trigger point injection technique for the treatment of cervicothoracic myofascial pain with botulinum toxin type. Anesthesiology 103:377–383
Ojala T, Arokoski JP, Partanen J (2006) The effects of small doses of botulinum toxin A on neck-shoulder myofascial pain syndrome. A double blind, randomized, and crossover trial. Clin J Pain 22:90–96
Göbel H, Heinze A, Reichel G, Hefter H, Benecke R (2006) Dysport myofascial pain study group. Efficacy and safety of a single botulinum type A toxin complex treatment (Dysport) for the relief of upper back myofascial pain syndrome: results from a randomized double-blind placebo-controlled multicentre study. Pain 125:82–88
Qerama E, Fuglsang-Frederiksen A, Kasch H, Basch FW, Jensen TS (2006) A double-blind, controlled study of botulinum toxin A in chronic myofascial pain. Neurology 67:241–245
Lew HL, Lee EH, Castaneda A, Kilma R, Date E (2008) Therapeutic doses of botulinum toxin A in treating neck and upper back pain of myofascial origin: a pilot study. Arch Phys Med Rehabil 89:75–80
Miller D, Richardson D, Eisa M, Bajwa RJ, Jabbari B (2009) Botulinum neurotoxin-A for treatment of refractory neck pain: a randomized, double-blind study. Pain Med 10:1012–1017
Benecke, R, Heinze A, Reichel G, Hefter H, Gobel H (2011) Dysport myofascial pain study group. Botulinum type A toxin complex for the relief of upper back myofascial. Pain Medicine 12:1607–1614
Ondo WG, Vuong KD, Derman HS (2004) Botulinum toxin A for chronic daily headache: a randomized, placebo-controlled, parallel design study. Cephalalgia 24:60–65
Mathew NT, Frishberg BM, Gawel M, Dimitrova R, Gibson J, Turkel C (2005) Botulinum toxin type A (BOTOX) for the prophylactic treatment of chronic daily headache: a randomized double-blind, placebo-controlled trial. Headache 45:293–307
Dodick DW, Mauskop A, Elkind AH, DeGryse R, Brin MF, Silberstein SD (2005) BOTOX CDH Study Group. Botulinum toxin type a for the prophylaxis of chronic daily headache: subgroup analysis of patients not receiving other prophylactic medications: a randomized double-blind, placebo-controlled study. Headache 45:315–324
Silberstein SD, Stark SR, Lucas SM, Christie SN, Degryse RE, Turkel CC (2005) Botulinum toxin type a for the prophylactic treatment of chronic daily headache: a randomized, double blind, placebo controlled trial. Mayo Clin Proc 80:1126–1137
Naumann M, So Y, Argoff CE, Childers MK, Dykstra DD, Gronseth GS, Jabbari B, Kaufmann HC, Schurch B, Silberstein SD, Simpson DM (2008) Therapeutics and technology assessment subcommittee of the American academy of neurology. Botulinum neurotoxin in the treatment of autonomic disorders and pain (an evidence-based review). Neurology 70:1707–1714
Saper JR, Mathew NT, Loder EW, DeGryse R, VanDenburgh AM (2007) BoNTA-009 study group. A double-blind, randomized, placebo-controlled comparison of botulinum toxin type A injection sites and doses in the prevention of episodic migraine. Pain Med 8:478–485
Elkind AH, O’Carroll P, Blumenfeld A, DeGryse R, Dimitrova R (2006) BoNTA-024-026-036 study group. A series of three sequential, randomized, controlled studies of repeated treatments with botulinum toxin type A for migraine prophylaxis. Pain 7:688–696
Aurora SK, Gawel M, Brandes JL, Pokta S, Vandenburgh AM (2007) Botulinum toxin type A prophylactic treatment of episodic migraine: a randomized double blind, placebo-controlled exploratory study. Headache 47:486–499
Rejala M, Poole AC, Schoenen J, Pascual J, Lei X, Thompson C (2007) European BoNTA headache study group. A multi-center randomized, placebo-controlled, parallel group study of multiple treatments of botulinum toxin type A (BoNTA) for the prophylaxis of episodic migraine headaches. Cephalalgia 27:492–503
Silberstein S, Mathew N, Saper J, Jenkins S (2000) Botulinum toxin type A as a migraine preventive treatment. For the BOTOX Migraine Clinical Research Group. Headache 40:445–450
Evers S, Vollmer-Haase J, Schwaag S, Rahmann A, Husstedt IW, Frese A (2004) Botulinum toxin A in the prophylactic treatment of migraine-a randomized, double-blind, placebo-controlled study. Cephalalgia 24:838–843
Vo AH, Satori R, Jabbari B, Green J, Killgore WD, Labutta R, Campbell WW (2007) Botulinum toxin type-a in the prevention of migraine: a double-blind controlled trial. Aviat Space Environ Med 78(5 Suppl):B113–B118
Blumenfeld AM, Schim JD, Chippendale TJ (2008) Botulinum toxin A and divalproex sodium for prophylactic treatment of episodic or chronic migraine. Headache 48:210–220
Padberg M, de Bruijn SF, de Haan RJ, Tavy DL (2004) Treatment of tension-type headache with botulinum toxin: a double-blind, placebo-controlled clinical trial. Cephalalgia 24:675–680
Schulte-Mattler WJ, Krack P (2004) Treatment of chronic tension- type headache with botulinum toxin A. A randomized, double blind, placebo-controlled multi-center study. Pain 109:110–114
Silberstein SD, Gobel H, Jensen R, Elkin AH, Degryse R, Walcott JM, Turkel C (2006) Botulinum toxin type A in the prophylactic treatment of tension- type headache: a multi-center, double blind, randomized, placebo-control, parallel-group study. Cephalalgia 26:790–800
Straube A, Empl M, Ceballos-Baumann A, Tolle T, Stefenelli U, Pfaffenrath V (2008) Dysport tension-type headache study group. Pericranial injection of botulinum toxin type A (Dysport) for tension-type headache- a multi-center, double blind, randomized, placebo-controlled study. Eur J Neurol 15:205–213
Rollnik JD, Tanneberger O, Shubert M, Schnider U, Dengler R (2000) Treatment of tension-type headache with botulinum toxin A: a double-blind, placebo-controlled study. Headache 40:300–305
Schmitt WJ, Slowey E, Fravi N, Weber S, Burgunder JM (2001) Effect of botulinum toxin A injections in the treatment of tension-type headaches: a double- blind, placebo-controlled trial. Headache 41:658–664
Harden RN, Cottrill J, Gagnon CM, Smitherman TA, Weinland SR, Tann B, Joseph P, Lee TS, Houle TT (2009) Botulinum toxin A in the treatment of chronic tension-type headache with cervical myofascial trigger points: a randomized, double-blind, placebo-controlled pilot study. Headache 49:732–743
Jabbari B, Babcock MS (2009) Treatment of plantar faciitis with botulinum toxin. In: Truong D, Dressler D, Hallett M (eds) Manual of botulinum toxin therapy. Cambridge University Press, Cambridge, pp 185–188
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Narges Moghimi, M.D, helped with the literature search and with final production of the manuscript.
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Jabbari, B., Machado, D. (2014). Clinical Use of Botulinum Neurotoxins: Pain. In: Foster, K. (eds) Clinical Applications of Botulinum Neurotoxin. Current Topics in Neurotoxicity, vol 5. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0261-3_6
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