Abstract
Taurine is a β-amino acid found ubiquitously in all cell types. Taurine has physiological roles as an osmolyte and antioxidant and plays a critical role in bile acid secretion. Intracellular taurine content is regulated by the taurine transporter (TauT), the expression of which is reduced in vitro by high glucose and in vivo in animal models of diabetes. In patients with diabetes, circulating and tissue taurine content are depleted proportionately with HbA1c. Taurine supplementation restores circulating and cellular taurine content and many of both in vitro and in vivo physiological and molecular biomarkers of diabetic complications. How this is achieved by an amino acid that 20 years ago was believed to be biochemically inert is as yet still not fully understood. This chapter seeks to discuss the current mechanisms behind TauT dysregulation in diabetes and explore the mechanisms by which taurine supplementation has beneficial effects in diabetic complications.
Keywords
- Retinal Pigment Epithelial Cell
- Taurine Supplementation
- Taurine Transport
- Taurine Content
- Taurine Uptake
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Birdsall TC (1998) Therapeutic applications of taurine. Altern Med Rev 3:128–136
Franconi F, Di Leo MA, Bennardini F, Ghirlanda G (2004) Is taurine beneficial in reducing risk factors for diabetes mellitus? Neurochem Res 29:143–150
Obrosova IG, Fathallah L, Stevens MJ (2001) Taurine counteracts oxidative stress and nerve growth factor deficit in early experimental diabetic neuropathy. Exp Neurol 172:211–219
Sturman J (1981) Cysteinesulfinic acid decarboxylase activity in the mammalian nervous system: absence from axons. J Neurochem 36:304–306
Brand A, Richter-Landsberg C (1997) Metabolism of acetate in rat brain neurons, astrocytes and cocultures: metabolic interactions between neurons and glia cells, monitored by NMR spectroscopy. Cell Mol Biol 43:645–657
Hansen SH (2001) The role of taurine in diabetes and the development of diabetic complications. Diabetes Metab Res Rev 17:330–346
Warskulat U, Borsch E, Reinehr R, Heller-Stilb B, Monnighoff I, Buchczyk D, Donner M, Flogel U, Kappert G, Soboll S, Beer S, Pfeffer K, Marschall HU, Gabrielsen M, Amiry-Moghaddam M, Ottersen OP, Dienes HP, Häussinger D (2006) Chronic liver disease is triggered by taurine transporter knockout in the mouse. FASEB J 20:574–576
Gaull GE, Rassin DK, Raihni NCHK (1977) Milk protein quantity and quality in low-birth-weight infants. III. Effects on sulfur amino acids in plasma and urine. J Pediatr 90:348–355
Tappaz ML (2004) Taurine biosynthetic enzymes and taurine transporter: molecular identification and regulations. Neurochem Res 29:83–96
Laidlaw SA, Shultz TD, Cecchino JT, Kopple JD (1988) Plasma and urine taurine levels in vegans. Am J Clin Nutr 47:660–663
De Luca G, Calpona PR, Caponetti A et al (2001) Taurine and osmoregulation: platelet taurine content, uptake, and release in type 2 diabetic patients. Metab Clin Exp 50:60–64
Han X, Patters AB, Jones DP et al (2006) The taurine transporter: mechanisms of regulation. Acta Physiol (Oxf) 187:61–73
Voss JW, Pedersen SF, Christensen ST, Lambert IH (2004) Regulation of the expression and subcellular localization of the taurine transporter TauT in mouse NIH3T3 fibroblasts. Eur J Biochem 271:4646–4658
Liu QR, López-Corcuera B, Nelson H et al (1992) Cloning and expression of a cDNA encoding the transporter of taurine and beta-alanine in mouse brain. Proc Natl Acad Sci USA 89:12145–12149
Jhiang SM, Fithian L, Tong Q, Mazzaferri E (1993) Cloning of the human taurine transporter and characterization of taurine uptake in thyroid cells. FEBS Lett 318:139–144
Ramamoorthy S, Leibach FH, Mahesh VB et al (1994) Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta. Biochem J 300:893–900
Lambert IH (2004) Regulation of the cellular content of the organic osmolyte taurine in mammalian cells. Neurochem Res 29:27–63
Han X, Budreau AM, Chesney RW (1999) Ser-322 is a critical site for PKC regulation of the MDCK cell taurine transporter (pNCT). J Am Soc Nephrol 10:1874–1879
Ganapathy V, Ramamoorthy JD, Del Monte MA et al (1995) Cyclic AMP-dependent up-regulation of the taurine transporter in a human retinal pigment epithelial cell line. Curr Eye Res 14:843–850
Miyamoto Y, Marczin N, Catravas JD, Del Monte MA (1996) Cholera toxin enhances taurine uptake in cultures of human retinal pigment epithelial cells. Curr Eye Res 15:229–236
Nakashima E, Pop-busui R, Towns R et al (2005) Regulation of the human taurine transporter by oxidative stress in retinal pigment epithelial cells stably transformed to overexpress aldose reductase. Antioxid Redox Signal 7:1530–1542
Franconi FA, Bennardini FR, Giuseppe A et al (1995) Plasma and platelet taurine are reduced in subjects with mellitus: effects of taurine. Am J Clin Nutr 61:1115–1119
Bianchi L, Lari R, Anichini R et al (2012) Taurine transporter gene expression in peripheral mononuclear blood cells of type 2 diabetic patients. Amino Acids 42:2267–2274
Merheb M, Daher RT, Nasrallah M et al (2007) Taurine intestinal absorption and renal excretion test in diabetic patients: a pilot study. Diabetes Care 30:2652–2654
Stevens MJ, Hosaka Y, Masterson JA et al (1999) Downregulation of the human taurine transporter by glucose in cultured retinal pigment epithelial cells. Am J Physiol 277:E760–E771
Trachtman H, Futterweit S, Bienkowski RS (1994) Taurine prevents glucose-induced lipid peroxidation and increased collagen production in cultured rat mesangial cells. Microvasc Res 47:759–765
Askwith T, Zeng W, Eggo MC, Stevens MJ (2009) Oxidative stress and dysregulation of the taurine transporter in high-glucose-exposed human Schwann cells: implications for pathogenesis of diabetic neuropathy. Am J Physiol Endocrinol Metab 297:E620–E628
Askwith T, Zeng W, Eggo MC, Stevens MJ (2012) Taurine reduces nitrosative stress and nitric oxide synthase expression in high glucose-exposed human Schwann cells. Exp Neurol 233:154–162
Zeng K, Xu H, Mi M et al (2010) Effects of taurine on glial cells apoptosis and taurine transporter expression in retina under diabetic conditions. Neurochem Res 35:1566–1574
Stevens MJ, Obrosova I, Cao X et al (2000) Effects of dl-alpha-lipoic acid on peripheral nerve conduction, blood flow, energy metabolism, and oxidative stress in experimental diabetic neuropathy. Diabetes 49:1006–1015
Stevens MJ, Dananberg J, Feldman EL et al (1994) The linked roles of nitric oxide, aldose reductase and, (Na+, K+)-ATPase in the slowing of nerve conduction in the streptozotocin diabetic rat. J Clin Investig 94:853–859
Obrosova IG, Stevens MJ (1999) Effect of dietary taurine supplementation on GSH and NAD(P)-redox status, lipid peroxidation, and energy metabolism in diabetic precataractous lens. Invest Ophthalmol Vis Sci 40:680–688
Park CJ, Park SA, Yoon TG et al (2005) Bupivacaine induces apoptosis via ROS in the Schwann cell line. J Dent Res 84:852–857
Odetti P, Pesce C, Traverso N et al (2003) Comparative trial of N-acetyl-cysteine, taurine, and oxerutin on skin and kidney damage in long-term experimental diabetes. Diabetes 52:499–505
Carneiro EM, Latorraca MQ, Araujo E et al (2009) Taurine supplementation modulates glucose homeostasis and islet function. J Nutr Biochem 20:503–511
Ribeiro RA, Santos-Silva JC, Vettorazzi JF et al (2012) Taurine supplementation prevents morpho-physiological alterations in high-fat diet mice pancreatic β-cells. Amino Acids 43:1791–1801
Pop-busui R, Sullivan K, Van Huysen C et al (2001) Depletion of taurine in experimental diabetic neuropathy: implications for nerve metabolic, vascular, and functional deficits. Exp Neurol 168:259–272
Li F, Abatan OI, Kim H et al (2006) Taurine reverses neurological and neurovascular deficits in Zucker diabetic fatty rats. Neurobiol Dis 22:669–676
Zeng K, Xu H, Mi M et al (2009) Dietary taurine supplementation prevents glial alterations in retina of diabetic rats. Neurochem Res 34:244–254
Selvaraj N, Bobby Z, Sathiyapriya V (2006) Effect of lipid peroxides and antioxidants on glycation of hemoglobin: an in vitro study on human erythrocytes. Clin Chim Acta 366:190–195
Nakaya Y, Minami A, Harada N et al (2000) Taurine improves insulin sensitivity in the Otsuka Long-Evans Tokushima Fatty rat, a model of spontaneous type 2 diabetes. Am J Clin Nutr 71:54–58
Zhang M, Bi LF, Fang JH et al (2004) Beneficial effects of taurine on serum lipids in overweight or obese non-diabetic subjects. Amino Acids 26:267–271
Spohr C, Brøns C, Winther K et al (2005) No effect of taurine on platelet aggregation in men with a predisposition to type 2 diabetes mellitus. Platelets 16:301–305
Moloney MA, Casey RG, O’Donnell DH (2010) Two weeks taurine supplementation reverses endothelial dysfunction in young male type 1 diabetics. Diab Vasc Dis Res 7:300–310
Nittynen L, Nurminen ML, Korpela R, Vapaatalo H (1999) Role of arginine, taurine and homocysteine in cardiovascular diseases. Ann Med 31:318–326
Militante JD, Lombardini JB (2002) Treatment of hypertension with oral taurine: experimental and clinical studies. Amino Acids 23:381–393
Lee E, Seo S, Jiang Z et al (2005) Reactive oxygen species mediate high glucose––induced plasminogen activator inhibitor-1 up-regulation in mesangial cells and in diabetic kidney. Kidney Int 67:1762–1771
Tas S, Sarandol E, Ayvalik SZ et al (2007) Vanadyl sulfate, taurine, and combined vanadyl sulfate and taurine treatments in diabetic rats: effects on the oxidative and antioxidative systems. Arch Med Res 38:276–283
Tang C, Han P, Oprescu AI et al (2007) Evidence for a role of superoxide generation in glucose-induced beta-cell dysfunction in vivo. Diabetes 56:2722–2731
Aruoma OI, Halliwell B, Hoey BM, Butler J (1988) The antioxidant action of taurine, hypotaurine and their metabolic precursors. Biocheml J 256:251–255
Schaffer SW, Azuma J, Mozaffari M (2009) Role of antioxidant activity of taurine in diabetes. Can J Physiol Pharmacol 87:91–99. doi:10.1139/Y08-110
Vesce S, Kirk L, Nicholls DG (2004) Relationships between superoxide levels and delayed calcium deregulation in cultured cerebellar granule cells exposed continuously to glutamate. J Neurochem 90:683–693
El Idrissi A, Trenkner E (1999) Growth factors and taurine protect against excitotoxicity by stabilizing calcium homeostasis and energy metabolism. J Neurosci 19:9459–9468
Schuller-Levis GB, Park E (2004) Taurine and its chloramine: modulators of immunity. Neurochem Res 29:117–126
Empl M, Renaud S, Erne B et al (2001) TNF-alpha expression in painful and nonpainful neuropathies. Neurology 56:1371–1377
Powell LA, Warpeha KM, Xu W (2004) High glucose decreases intracellular glutathione concentrations and upregulates inducible nitric oxide synthase gene expression in intestinal epithelial cells. J Mol Endocrinol 33:797–803
Foos TM, Wu J-Y (2002) The role of taurine in the central nervous system and the modulation of intracellular calcium homeostasis. Neurochem Res 27:21–26
Li F, Obrosova IG, Abatan O et al (2005) Taurine replacement attenuates hyperalgesia and abnormal calcium signaling in sensory neurons of STZ-D rats. Am J Physiol Endocrinol Metab 288:E29–E36
Vague P, Coste TC, Jannot MF et al (2004) C-peptide, Na+, K+-ATPase, and diabetes. Exp Diabesity Res 5:37–50
Stevens MJ, Feldman EL, Greene DA (1995) The aetiology of diabetic neuropathy: the combined roles of metabolic and vascular defects. Diabet Med 12:566–579
Di Leo MAS, Santini SA, Cercone S et al (2002) Chronic taurine supplementation ameliorates oxidative stress and Na+ K+ ATPase impairment in the retina of diabetic rats. Amino Acids 23:401–406
Suzuki T, Suzuki T, Wada T et al (2002) Taurine as a constituent of mitochondrial tRNAs: new insights into the functions of taurine and human mitochondrial diseases. EMBO J 21:6581–6589
Suzuki T, Wada T, Saigo K, Watanabe K (2001) Novel taurine-containing uridine derivatives and mitochondrial human diseases. Nucleic Acids Res 257–258
Jong CJ, Azuma J, Schaffer S (2012) Mechanism underlying the antioxidant activity of taurine: prevention of mitochondrial oxidant production. Amino Acids 42:2223–2232
Hansen SH, Andersen ML, Cornett C et al (2010) A role for taurine in mitochondrial function. J Biomed Sci 17:S23
Chen K, Zhang Q, Wang J et al (2009) Taurine protects transformed rat retinal ganglion cells from hypoxia-induced apoptosis by preventing mitochondrial dysfunction. Brain Res 1279:131–138
Huang C-C, Hall AC, Lim P-H (2007) Characterisation of three pathways for osmolyte efflux in human erythroleukemia cells. Life Sci 81:732–739
Ito T, Schaffer SW, Azuma J (2012) The potential usefulness of taurine on diabetes mellitus and its complications. Amino Acids 42:1529–1539
Higo S, Miyata S, Jiang QY et al (2008) Taurine administration after appearance of proteinuria retards progression of diabetic nephropathy in rats. Kobe J Med Sci 54:E35–E45
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Askwith, T. (2014). Taurine Treatment for Complications of Diabetes. In: Obrosova, I., Stevens, M., Yorek, M. (eds) Studies in Diabetes. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4899-8035-9_10
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DOI: https://doi.org/10.1007/978-1-4899-8035-9_10
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