RB and Lamins in Cell Cycle Regulation and Aging

  • Brian K. Kennedy
  • Juniper K. Pennypacker
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 773)


While speculation has centered on a role for nuclear lamins in tumor progression for many years, most of the diseases that have been linked to lamin mutation are dystrophic in nature, often limiting the proliferation potential of affected cells in vivo and in vitro. Nevertheless, these lamin mutations, particularly in the LMNA gene that encodes A-type lamins, have provided an interesting tool set to understand functions of nuclear intermediate filament proteins in cell cycle progress and various means of exit, including quiescence, senescence, and differentiation down various lineages. The picture that has emerged is complex with lamins controlling the activity of key cell cycle factors such as the retinoblastoma protein (RB) and interacting with several important signal transduction pathways. Here we describe the current state of knowledge and speculate that lamins may be intimately involved in the regulation of cell proliferation, acting at the interface between cancer and aging.


A-type lamins B-type lamins Retinoblastoma protein LMNA gene Lamins Aging Progerin Senescence Cancer Cell cycle progression Telomeres p53 



Ataxia telangiectasia and Rad3-related protein


Autosomal dominant leukodystrophy


Cyclin-dependent kinase


Dilated cardiomyopathy type 1A


Extracellular signal-regulated kinases


Hutchinson–Gilford Progeria syndrome


Lamina-associated polypeptide 2α


Mouse double minute 2 homolog


Reactive oxygen species


Retinoblastoma protein


Senescence-associated secretory phenotype


Silent mating-type information regulation 2 homolog 1


von Hippel–Lindau gene



Lamin-related research in the lab of B.K.K. is supported by a grant from the National Institute of Aging (R01 AG024287).


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.The Buck Institute for Research on AgingNovatoUSA

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