Nuclear Morphometry, Epigenetic Changes, and Clinical Relevance in Prostate Cancer

  • Robert W. VeltriEmail author
  • Christhunesa S. Christudass
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 773)


Nuclear structure alterations in cancer involve global genetic (mutations, amplifications, copy number variations, translocations, etc.) and epigenetic (DNA methylation and histone modifications) events that dramatically and dynamically spatially change chromatin, nuclear body, and chromosome organization. In prostate cancer (CaP) there appears to be early (<50 years) versus late (>60 years) onset clinically significant cancers, and we have yet to clearly understand the hereditary and somatic-based molecular pathways involved. We do know that once cancer is initiated, dedifferentiation of the prostate gland occurs with significant changes in nuclear structure driven by numerous genetic and epigenetic processes. This review focuses upon the nuclear architecture and epigenetic dynamics with potential translational clinically relevant applications to CaP. Further, the review correlates changes in the cancer-driven epigenetic process at the molecular level and correlates these alterations to nuclear morphological quantitative measurements. Finally, we address how we can best utilize this knowledge to improve the efficacy of personalized treatment of cancer.


Prostate cancer Epigenetics Nuclear morphology Nuclear roundness 



Androgen receptor


Prostate cancer


Chromosome territory


Charge coupled device


High-grade prostate intraepithelial neoplasia




Nuclear envelope


Nuclear envelope transmembrane protein


Nuclear morphometric descriptor


Nuclear roundness factor


Nuclear roundness variance


Polycomb repressive complex 2


Prostate-specific antigen


Quantitative nuclear grade


Radical prostatectomy


Trichostatin A


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Robert W. Veltri
    • 1
    Email author
  • Christhunesa S. Christudass
    • 1
  1. 1.The Brady Urological Research InstituteBaltimoreUSA

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