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Control of Nuclear Size by NPC Proteins

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Cancer Biology and the Nuclear Envelope

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 773))

Abstract

The architecture of the cell nucleus in cancer cells is often altered in a manner associated with the tumor type and aggressiveness. Therefore, it has been the central criterion in the pathological diagnosis and prognosis of cancer. However, the molecular mechanism behind these observed changes in nuclear morphology, including size, remains completely unknown. Based on our current understanding of the physiology of the nuclear pore complex (NPC) and its constituents, which are collectively referred to as nucleoporins (Nups), we discuss how the structural and functional ablation of the NPC and Nups could directly or indirectly contribute to the changes in nuclear size observed in cancer cells.

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Abbreviations

AF:

Atrial fibrillation

INM:

Inner nuclear membrane

KTIP:

Kap121p transport inhibitory pathway

LINC:

Linker of nucleoskeleton and cytoskeleton

MAC:

Macronucleus

MIC:

Micronucleus

NE:

Nuclear envelope

NPC:

Nuclear pore complex

NTR:

Nuclear transport receptor

Nup:

Nucleoporin

ONM:

Outer nuclear membrane

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  1. Cellular Dynamics Laboratory, RIKEN, WAKO, Saitama, 351-0198, Japan

    Masatoshi Takagi & Naoko Imamoto

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  1. Masatoshi Takagi
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    Eric C. Schirmer

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    Jose I. de las Heras

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Takagi, M., Imamoto, N. (2014). Control of Nuclear Size by NPC Proteins. In: Schirmer, E., de las Heras, J. (eds) Cancer Biology and the Nuclear Envelope. Advances in Experimental Medicine and Biology, vol 773. Springer, New York, NY. https://doi.org/10.1007/978-1-4899-8032-8_26

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