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Cancer Biology and the Nuclear Envelope pp 523–535Cite as

Nuclear Envelope Invaginations and Cancer

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 773))

Abstract

The nuclear envelope (NE) surrounds the nucleus and separates it from the cytoplasm. The NE is not a passive structural component, but rather contributes to various cellular processes such as genome organization, transcription, signaling, and stress responses. Although the NE is mostly a smooth surface, it also forms invaginations that can reach deep into the nucleoplasm and may even traverse the nucleus completely. Cancer cells are generally characterized by irregularities and invaginations of the NE that are of diagnostic and prognostic significance. In the current chapter, we describe the link between nuclear invaginations and irregularities with cancer and explore possible mechanistic roles they might have in tumorigenesis.

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Abbreviations

CCT-a:

CTP:phosphocholine-cytidylyltransferase-α

HCC:

Hepatocellular carcinoma

HGPS:

Hutchinson–Gilford Progeria Syndrome

INM:

Inner nuclear membrane

MARs:

Matrix attachment regions

NE:

Nuclear envelope

NR:

Nucleoplasmic reticulum

PaCa:

Pancreatic carcinoma

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  1. Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 3RE, UK

    Ashraf N. Malhas & David J. Vaux

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  1. Ashraf N. Malhas
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  1. University of Edinburgh Wellcome Trust Centre for Cell Biology, Edinburgh, United Kingdom

    Eric C. Schirmer

  2. University of Edinburgh Wellcome Trust Centre for Cell Biology, Edinburgh, United Kingdom

    Jose I. de las Heras

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Malhas, A.N., Vaux, D.J. (2014). Nuclear Envelope Invaginations and Cancer. In: Schirmer, E., de las Heras, J. (eds) Cancer Biology and the Nuclear Envelope. Advances in Experimental Medicine and Biology, vol 773. Springer, New York, NY. https://doi.org/10.1007/978-1-4899-8032-8_24

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