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Wnt Signaling Proteins Associate with the Nuclear Pore Complex: Implications for Cancer

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Cancer Biology and the Nuclear Envelope

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 773))

Abstract

Several components of the Wnt signaling pathway have in recent years been linked to the nuclear pore complex. β-catenin, the primary transducer of Wnt signals from the plasma membrane to the nucleus, has been shown to transiently associate with different FG-repeat containing nucleoporins (Nups) and to translocate bidirectionally through pores of the nuclear envelope in a manner independent of classical transport receptors and the Ran GTPase. Two key regulators of β-catenin, IQGAP1 and APC, have also been reported to bind specific Nups or to locate at the nuclear pore complex. The interaction between these Wnt signaling proteins and different Nups may have functional implications beyond nuclear transport in cellular processes that include mitotic regulation, centrosome positioning and cell migration, nuclear envelope assembly/disassembly, and the DNA replication checkpoint. The broad implications of interactions between Wnt signaling proteins and Nups will be discussed in the context of cancer.

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Abbreviations

APC:

Adenomatous polyposis coli

IQGAP1:

IQ motif containing GTPase activating protein

MTOC:

Microtubule organizing center

NE:

Nuclear envelope

NES:

Nuclear export signal

NLS:

Nuclear localization signal

NPC:

Nuclear pore complex

NUP:

Nucleoporin

PML:

Promyelocytic leukemia

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  1. Michael Johnson

    Present address: Westmead Institute for Cancer Research, Westmead Millennium Institute at Westmead Hospital, The University of Sydney, Darcy Road, 412, Westmead, NSW, 2145, Australia

Authors and Affiliations

  1. Westmead Institute for Cancer Research, Westmead Millennium Institute at Westmead Hospital, The University of Sydney, Darcy Road, 412, Westmead, NSW, 2145, Australia

    Manisha Sharma, Mariana Brocardo, Cara Jamieson & Beric R. Henderson

  2. Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St Leonards, NSW, Australia

    Michael Johnson

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  1. Manisha Sharma
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  2. Michael Johnson
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  3. Mariana Brocardo
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  4. Cara Jamieson
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Correspondence to Manisha Sharma or Beric R. Henderson .

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  1. University of Edinburgh Wellcome Trust Centre for Cell Biology, Edinburgh, United Kingdom

    Eric C. Schirmer

  2. University of Edinburgh Wellcome Trust Centre for Cell Biology, Edinburgh, United Kingdom

    Jose I. de las Heras

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Sharma, M., Johnson, M., Brocardo, M., Jamieson, C., Henderson, B.R. (2014). Wnt Signaling Proteins Associate with the Nuclear Pore Complex: Implications for Cancer. In: Schirmer, E., de las Heras, J. (eds) Cancer Biology and the Nuclear Envelope. Advances in Experimental Medicine and Biology, vol 773. Springer, New York, NY. https://doi.org/10.1007/978-1-4899-8032-8_16

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