Roles of the Nucleoporin Tpr in Cancer and Aging

  • Chelsi J. Snow
  • Bryce M. PaschalEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 773)


Tpr is a prominent architectural component of the nuclear pore complex that forms the basket-like structure on the nucleoplasmic side of the pore. Tpr, which stands for translocated promoter region, was originally described in the context of oncogenic fusions with the receptor tyrosine kinases Met, TRK, and Raf. Tpr has been since implicated in a variety of nuclear functions, including nuclear transport, chromatin organization, regulation of transcription, and mitosis. More recently, Tpr function has been linked to events including p53 signaling and premature aging in Hutchinson–Gilford Progeria Syndrome (HGPS). Here we provide an overview of the various processes that involve Tpr, and discuss how the levels and localization of a single protein can affect diverse pathways in the cell.


Tpr Translocated promoter region Nuclear pore Met TRK Raf Oncogenic fusion Mad1 Mad2 



Anaphase promoting complex


Epidermal growth factor


Heterochromatin exclusion zone


Hepatocyte growth factor


Human osteogenic sarcoma


Hutchinson–Gilford progeria syndrome


Male-specific lethal




Nuclear export signal


Nuclear localization signal


Nuclear pore complex




Spindle assembly checkpoint


Translocated promoter region


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© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Center for Cell SignalingUniversity of VirginiaCharlottesvilleUSA
  2. 2.Department of Biochemistry and Molecular Genetics, Health Sciences CenterUniversity of VirginiaCharlottesvilleUSA

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