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Hemodiafiltration

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Core Concepts in Dialysis and Continuous Therapies

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Abstract

Hemodiafiltration is a form of renal replacement therapy which employs convection and diffusion to enhance the clearance of larger uremic solutes which are not adequately removed by conventional low-flux hemodialysis. Most modern dialysis machines are able to deliver hemodiafiltration. The main limiting factor that prevents its widespread implementation is the requirement for dialysis units to be capable of producing large quantities of ultrapure dialysis fluid. The benefits of hemodiafiltration include better hemodynamic stability and enhanced clearance of middle molecules such as ß2-microglobulin, especially in patients without residual kidney function. There may be a survival advantage with hemodiafiltration particularly when delivering high convective volumes although this requires confirmation in future clinical trials. Hemodiafiltration is a safe and effective mode of renal replacement therapy which offers some advantages over conventional hemodialysis.

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Authors and Affiliations

  1. Department of Renal Medicine, Lister Hospital, Corey Mills Lane, Stevenage, Hertfordshire, UK

    Jonathan Wong MBBS, MRCP, Sivakumar Sridharan MBBS, MRCP(UK), Roger Greenwood MSc, ACGI, MD, FRCP & Ken Farrington BSc, MB ChB, MD, FRCP

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  1. Jonathan Wong MBBS, MRCP
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  2. Sivakumar Sridharan MBBS, MRCP(UK)
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  3. Roger Greenwood MSc, ACGI, MD, FRCP
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  4. Ken Farrington BSc, MB ChB, MD, FRCP
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Corresponding author

Correspondence to Ken Farrington BSc, MB ChB, MD, FRCP .

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Editors and Affiliations

  1. Department of Nephrology, Beaumont Hospital, Dublin, Dublin, Ireland

    Colm C. Magee

  2. Department of Medicine/Renal Division, Brigham and Women's Hospital, BOSTON, Massachusetts, USA

    J. Kevin Tucker

  3. Global and Continuing Education, Harvard Medical School, Boston, Massachusetts, USA

    Ajay K. Singh

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Wong, J., Sridharan, S., Greenwood, R., Farrington, K. (2016). Hemodiafiltration. In: Magee, C., Tucker, J., Singh, A. (eds) Core Concepts in Dialysis and Continuous Therapies. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7657-4_23

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  • DOI: https://doi.org/10.1007/978-1-4899-7657-4_23

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