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Deep Brain Stimulation for Neuropsychiatric Disorders

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Translational Neuroscience

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Abstract

Neuropsychiatric disorders that are refractory to best medical management continue to pose a significant challenge. Advances in molecular neuroscience and neuroimaging have started to reveal how dysfunction in specific limbic networks mediates these disorders. This knowledge, along with concurrent advances in neurosurgical techniques, has lead to the increasing use of deep brain stimulation (DBS) for the treatment of neuropsychiatric disorders. Here we review the role of DBS for obsessive-compulsive disorder (OCD), depression, addiction, post-traumatic stress disorder (PTSD), and anorexia nervosa (AN). We emphasize the use of translational techniques such as neuroimaging, molecular neuroscience, and animal models in guiding and evaluating the use of DBS for these challenging disorders.

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Authors and Affiliations

  1. Division of Neurosurgery, Toronto Western Hospital, 399 Bathurst Street, West Wing 4-431, Toronto, ON, Canada, M5T 2S8

    Ausaf A. Bari MD, PhD

  2. Department of Neurosurgery, National Neuroscience Institute, Jalan Tan Tock Seng, Singapore, 308433, Singapore

    Nicolas Kon Kam King FRCSEd(SN), PhD, DIC

  3. Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, Krembil Neuroscience Center, Toronto, ON, Canada, M5T 2S8

    Nir Lipsman MD, PhD & Andres M. Lozano MD, PhD

  4. University of Toronto, Toronto, ON, Canada

    Nir Lipsman MD, PhD & Andres M. Lozano MD, PhD

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  1. Ausaf A. Bari MD, PhD
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  2. Nicolas Kon Kam King FRCSEd(SN), PhD, DIC
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  3. Nir Lipsman MD, PhD
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  4. Andres M. Lozano MD, PhD
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Correspondence to Ausaf A. Bari MD, PhD .

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  1. UnivofCA-SanDiego,VeteransAdmintnMedCntr, Translational Neuroscience Institute, La Jolla, California, USA

    Mark H. Tuszynski

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Bari, A.A., King, N.K.K., Lipsman, N., Lozano, A.M. (2016). Deep Brain Stimulation for Neuropsychiatric Disorders. In: Tuszynski, M. (eds) Translational Neuroscience. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7654-3_26

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