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Translating Gene Therapy for Pain from Animal Studies to the Clinic

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Translational Neuroscience

Abstract

The use of gene transfer techniques, designed to effect the continuous release of analgesic peptides, offers the possibility to treat what may otherwise be intractable pain. In this chapter, we review the biology underlying this approach, the results of preclinical experiments in animal models, the human trials that have been completed, and prospects for the near-term future.

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Authors and Affiliations

  1. PeriphaGen, Inc., 2100 Wharton Street, Suite 701, Pittsburgh, PA, 15203, USA

    Darren Wolfe PhD, David Krisky PhD, James Goss PhD & James Wechuck PhD

  2. Department of Neurology, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI, 48109, USA

    Marina Mata MD

  3. Department of Neurology, University of Michigan, 1914 Taubman Center, 1500 East Medical Center Drive, Ann Arbor, MI, 48109, USA

    David J. Fink MD

Authors
  1. Darren Wolfe PhD
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  2. David Krisky PhD
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  3. James Goss PhD
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  4. James Wechuck PhD
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  5. Marina Mata MD
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  6. David J. Fink MD
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Corresponding authors

Correspondence to Darren Wolfe PhD or David J. Fink MD .

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Editors and Affiliations

  1. UnivofCA-SanDiego,VeteransAdmintnMedCntr, Translational Neuroscience Institute, La Jolla, California, USA

    Mark H. Tuszynski

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Wolfe, D., Krisky, D., Goss, J., Wechuck, J., Mata, M., Fink, D.J. (2016). Translating Gene Therapy for Pain from Animal Studies to the Clinic. In: Tuszynski, M. (eds) Translational Neuroscience. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7654-3_10

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