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Evolving Technologies in MR and PET for Imaging Atherosclerosis

  • Maciej Jakuciński
  • Karol P. BudohoskiEmail author
  • Victoria E. L. Young
  • Peter J. Kirkaptrick
  • Mirosław Ząbek
  • Leszek Królicki

Abstract

Patients with carotid atherosclerosis develop symptoms most commonly due to plaque progression or rupture. Many factors influence the risk of a lesion rupturing. The degree of stenosis as seen on digital subtraction angiography does not accurately explain the associated clinical events. The term “vulnerable plaque” is used to describe plaques which have a high risk of causing symptoms. Such plaques typically have active inflammation, with features such as a thin fibrous cap overlying a large lipid-rich necrotic core, often with plaque hemorrhage. The endothelial surface of such plaques may be irregular, with endothelial denudation or ulceration. A plaque may be characterized as “vulnerable” based on morphology without necessarily causing a significant stenosis. Various means of depicting the characteristics of plaque vulnerability are available. This chapter aims to describe magnetic resonance imaging and positron emission tomography and their uses in imaging unstable carotid atherosclerosis.

Keywords

Carotid atherosclerosis Magnetic resonance imaging Positron emission tomography Stroke 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Maciej Jakuciński
    • 1
  • Karol P. Budohoski
    • 2
    Email author
  • Victoria E. L. Young
    • 3
  • Peter J. Kirkaptrick
    • 2
  • Mirosław Ząbek
    • 1
  • Leszek Królicki
    • 1
  1. 1.Department of RadiologyMazowiecki Szpital BrodnowskiWarsawPoland
  2. 2.Division of Neurosurgery, Department of Clinical NeurosciencesAddenbrooke’s Hospital, University of CambridgeCambridgeUK
  3. 3.Department of RadiologyUniversity of CambridgeCambridgeUK

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