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Post-Traumatic Arthritis pp 221–233Cite as

Potential Mechanism of PTA: Alterations in Joint Loading

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Abstract

The complex interaction between biomechanics and biology in the etiology and progression of arthritis remains unknown. The challenge becomes one of understanding joint mechanics in both normal and traumatized joints. This requires consideration of how loads are transferred across the joint, how they are distributed among the joint tissues, and how injury affects joint stability. Lessons learned from tribology of man-made joints underscore the importance of the interaction between joint force and stability. Animal models used to induce arthritic changes, often by creating joint instability, are hampered by poor control and inadequate measurement of the mechanical environment. However, considerable progress is underway, supported by increases in computational tools and computing power, the availability of mouse models that can incorporate specific genetic alterations, and more robust imaging techniques for longitudinally modeling the resulting alterations in joint tissues.

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Authors and Affiliations

  1. Department of Biomechanics, Hospital for Special Surgery, 535 East 70th Street, New York, NY, 10021, USA

    Timothy M. Wright Ph.D. & Suzanne A. Maher Ph.D.

Authors
  1. Timothy M. Wright Ph.D.
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  2. Suzanne A. Maher Ph.D.
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Corresponding author

Correspondence to Timothy M. Wright Ph.D. .

Editor information

Editors and Affiliations

  1. Professor, Department of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina, USA

    Steven A. Olson, MD

  2. Laszlo Ormandy Professor, Department of Orthopedic Surgery, Duke University Medical Center, Durham, North Carolina, USA

    Farshid Guilak, PhD

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Wright, T.M., Maher, S.A. (2015). Potential Mechanism of PTA: Alterations in Joint Loading. In: Olson, MD, S., Guilak, PhD, F. (eds) Post-Traumatic Arthritis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7606-2_18

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  • DOI: https://doi.org/10.1007/978-1-4899-7606-2_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-7605-5

  • Online ISBN: 978-1-4899-7606-2

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