Skip to main content

Pulse Sequences for fMRI

  • Chapter
  • First Online:
fMRI: From Nuclear Spins to Brain Functions

Part of the book series: Biological Magnetic Resonance ((BIMR,volume 30))

Abstract

This chapter examines the pulse sequences that are available for conducting fMRI. The chapter describes sequences capable of generating T2*-, T2- and frequency-dependent contrast. In the section ‘Introduction’, a set of criteria is given which a pulse sequence should ideally fulfil. All described sequences are measured against these. The majority of the chapter is devoted to the echo-planar imaging (EPI) sequence, as this represents a gold standard against which other sequences can be measured. The numerous improvements and extensions to this sequence for fMRI are paid particular attention. In addition, the application of fast low-angle shot (FLASH), rapid acquisition with relaxation enhancement (RARE)/fast spin echo (FSE), gradient spin echo (GRASE) and steady-state free precession (SSFP) sequences is considered for relevant contrasts.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 299.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Ahn CB, Kim JH, Cho ZH (1986) High-speed spiral-scan echo planar NMR imaging - I. IEEE Trans Med Imaging MI-5:2–7

    Article  Google Scholar 

  • Alsop DC (1997) Phase insensitive preparation of single-shot RARE: application to diffusion imaging in humans. Magn Reson Med 38:527–533

    Article  CAS  PubMed  Google Scholar 

  • Auerbach EJ, Heberlein K, Hu X (2002) High-resolution T2 fMRI at high magnetic fields using PSIF. In: Proceedings of the 10th Annual Meeting of ISMRM, pp 123

    Google Scholar 

  • Bandettini PA, Wong EC, Jesmanowicz A, Hinks RS, Hyde JS (1994) Spin-echo and gradient-echo EPI of human brain activation using BOLD contrast: a comparative study at 1.5 T. NMR Biomed 7:12–20

    Article  CAS  PubMed  Google Scholar 

  • Bandettini PA, Jesmanowicz A, Van Kylen J, Birn RM, Hyde JS (1998) Functional MRI of brain activation induced by scanner acoustic noise. Magn Reson Med 39:410–416

    Article  CAS  PubMed  Google Scholar 

  • Barth M, Meyer H, Kannengiesser SAR, Polimeni JR, Wald LL, Norris DG (2010) T-2-Weighted 3D fMRI Using S-2-SSFP at 7 Tesla. Magn Reson Med 63:1015–1020

    Article  PubMed Central  PubMed  Google Scholar 

  • Block KT, Frahm J (2005) Spiral imaging: a critical appraisal. J Magn Reson Imaging 21:657–668

    Article  PubMed  Google Scholar 

  • Börnert P, Aldefeld B, Eggers H (2000) Reversed spiral MR imaging. Magn Reson Med 44:479–484

    Article  PubMed  Google Scholar 

  • Bowen C, Menon R, Gati J (2005) High field balanced-SSFP FMRI: a BOLD technique with excellent tissue sensitivity and superior large vessel suppression. In: Proceedings of the 13th annual meeting of ISMRM, pp 119

    Google Scholar 

  • Bowen C, Mason J, Menon R, Gati J (2006) SSFP FMRI: examining a diffusion contrast mechanism using varied flip angles. In: Proceedings of the 14th annual meeting of ISMRM, pp 665

    Google Scholar 

  • Boxerman JL, Bandettini PA, Kwong KK, Baker JR, Davis TL, Rosen BR, Weisskoff RM (1995) The intravascular contribution to fMRI signal change: Monte Carlo modeling and diffusion-weighted studies in vivo. Magn Reson Med 34:4–10

    Article  CAS  PubMed  Google Scholar 

  • Breuer FA, Kannengiesser SAR, Blaimer M, Seiberlich N, Jakob PM, Griswold MA (2009) General formulation for quantitative G-factor calculation in GRAPPA reconstructions. Magn Reson Med 62:739–746

    Article  PubMed  Google Scholar 

  • Buur PF, Norris DG, Hesse CW (2008) Extraction of task-related activation from multi-echo BOLD fMRI. IEEE J Sel Top Signal Process 2:954–964

    Article  Google Scholar 

  • Buur PF, Poser BA, Norris DG (2009) A dual echo approach to removing motion artefacts in fMRI time series. NMR Biomed 22:551–560

    Article  PubMed  Google Scholar 

  • Chamberlain R, Park JY, Corum C, Yacoub E, Uğurbil K, Jack CR, Garwood M (2007) RASER: a new ultrafast magnetic resonance imaging method. Magn Reson Med 58:794–799

    Article  PubMed  Google Scholar 

  • Chang H, Fitzpatrick JM (1992) A technique for accurate magnetic-resonance-imaging in the presence of field inhomogeneities. IEEE Trans Med Imaging 11:319–329

    Article  CAS  PubMed  Google Scholar 

  • Chapman B, Turner R, Ordidge RJ, Doyle M, Cawley M, Coxon R, Glover P, Mansfield P (1987) Real-time movie imaging from a single cardiac cycle by NMR. Magn Reson Med 5:246–254

    Article  CAS  PubMed  Google Scholar 

  • Chen NK, Wyrwicz AM (1999) Removal of intravoxel dephasing artifact in gradient-echo images using a field-map based RF refocusing technique. Magn Reson Med 42:807–812

    Article  CAS  PubMed  Google Scholar 

  • Chen NK, Wyrwicz AM (2001) Optimized distortion correction technique for echo planar imaging. Magn Reson Med 45:525–528

    Article  CAS  PubMed  Google Scholar 

  • Cohen MS, Weisskoff RM (1991) Ultra-fast imaging. Magn Reson Imaging 9:1–37

    Article  CAS  PubMed  Google Scholar 

  • Constable RT, Kennan RP, Puce A, McCarthy G, Gore JC (1994) Functional NMR imaging using fast spin echo at 1.5 T. Magn Reson Med 31:686–690

    Article  CAS  PubMed  Google Scholar 

  • de Zwart JA, van Gelderen P, Kellman P, Duyn JH (2002a) Application of sensitivity-encoded echo-planar imaging for blood oxygen level-dependent functional brain imaging. Magn Reson Med 48:1011–1020

    Article  PubMed  Google Scholar 

  • de Zwart JA, van Gelderen P, Kellman P, Duyn JH (2002b) Reduction of gradient acoustic noise in MRI using SENSE-EPI. Neuroimage 16:1151–1155

    Article  PubMed  Google Scholar 

  • de Zwart JA, van Gelderen P, Golay X, Ikonomidou VN, Duyn JH (2006) Accelerated parallel imaging for functional imaging of the human brain. NMR Biomed 19:342–351

    Article  PubMed  Google Scholar 

  • Dreher W, Leibfritz D (2002) Fast proton spectroscopic imaging with high signal-to-noise ratio: spectroscopic RARE. Magn Reson Med 47:523–528

    Article  CAS  PubMed  Google Scholar 

  • Duong TQ, Yacoub E, Adriany G, Hu X, Uğurbil K, Vaughan JT, Merkle H, Kim SG (2002) High-resolution, spin-echo BOLD, and CBF fMRI at 4 and 7 T. Magn Reson Med 48:589–593

    Article  PubMed  Google Scholar 

  • Duyn JH (1997) Steady state effects in fast gradient echo magnetic resonance imaging. Magn Reson Med 37:559–568

    Article  CAS  PubMed  Google Scholar 

  • Eden GF, Joseph JE, Brown HE, Brown CP, Zeffiro TA (1999) Utilizing hemodynamic delay and dispersion to detect fMRI signal change without auditory interference: the behavior interleaved gradients technique. Magn Reson Med 41:13–20

    Article  CAS  PubMed  Google Scholar 

  • Edmister WB, Talavage TM, Ledden PJ, Weisskoff RM (1999) Improved auditory cortex imaging using clustered volume acquisitions. Hum Brain Mapp 7:89–97

    Article  CAS  PubMed  Google Scholar 

  • Feinberg DA, Reese TG, Wedeen VJ (2002) Simultaneous echo refocusing in EPI. Magn Reson Med 48:1–5

    Article  PubMed  Google Scholar 

  • Feinberg DA, Moeller S, Smith SM, Auerbach E, Ramanna S, Glasser MF, Miller KL, Uğurbil K, Yacoub E (2010) Multiplexed echo planar imaging for sub-second whole brain FMRI and fast diffusion imaging. Plos ONE 5. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015710

  • Fernandez-Seara MA, Aznarez-Sanado M, Mengual E, Loayza FR, Pastor MA (2009) Continuous performance of a novel motor sequence leads to highly correlated striatal and hippocampal perfusion increases. Neuroimage 47:1797–1808

    Article  PubMed  Google Scholar 

  • Frahm J, Haase A, Hänicke W, Matthaei D, Bomsdorf H, Helzel T (1985) Chemical-shift selective MR imaging using a whole-body magnet. Radiology 156:441–444

    Article  CAS  PubMed  Google Scholar 

  • Frahm J, Merboldt KD, Hänicke W (1988) Direct FLASH MR imaging of magnetic-field inhomogeneities by gradient compensation. Magn Reson Med 6:474–480

    Article  CAS  PubMed  Google Scholar 

  • Frahm J, Bruhn H, Merboldt K-D, Hänicke W (1992) Dynamic MR imaging of human brain oxygenation during rest and photic stimulation. J Magn Reson Imaging 2:501–505

    Article  CAS  PubMed  Google Scholar 

  • Frahm J, Merboldt KD, Hänicke W (1993) Functional MRI of human brain activation at high spatial resolution. Magn Reson Med 29:139–144

    Article  CAS  PubMed  Google Scholar 

  • Frahm J, Merboldt, K.-D., Hänicke W (1994) The influence of the slice-selection gradient on functional MRI of human brain activation. J Magn Reson 103B:91–93

    Article  Google Scholar 

  • Friston KJ, Harrison L, Penny W (2003) Dynamic causal modelling. Neuroimage 19:1273–1302

    Article  CAS  PubMed  Google Scholar 

  • Glover GH (1999) 3D z-shim method for reduction of susceptibility effects in BOLD fMRI. Magn Reson Med 42:290–299

    Article  CAS  PubMed  Google Scholar 

  • Glover GH, Lai S (1998) Reduction of susceptibility effects in BOLD fMRI using tailored RF pulses. In: Proceedings 6th meeting of the international society for Magn Reson Med, Sydney, pp 298

    Google Scholar 

  • Glover GH, Law CS (2001) Spiral-in/out BOLD fMRI for increased SNR and reduced susceptibility artifacts. Magn Reson Med 46:515–522

    Article  CAS  PubMed  Google Scholar 

  • Goerke U, Garwood M, Uğurbil K (2011) Functional magnetic resonance imaging using RASER. Neuroimage 54:350–360

    Article  PubMed Central  PubMed  Google Scholar 

  • Golay X, Pruessmann KP, Weiger M, Crelier GR, Folkers PJM, Kollias SS, Boesiger P (2000) PRESTO-SENSE: an ultrafast whole-brain fMRI technique. Magn Reson Med 43:779–786

    Article  CAS  PubMed  Google Scholar 

  • Gowland PA, Bowtell R (2007) Theoretical optimization of multi-echo fMRI data acquisition. Phys Med Biol 52:1801–1813

    Article  CAS  PubMed  Google Scholar 

  • Griswold MA, Jakob PM, Heidemann RM, Nittka M, Jellus V, Wang J, Kiefer B, Haase A (2002) Generalized autocalibrating partially parallel acquisitions (GRAPPA). Magn Reson Med 47:1202–1210

    Article  PubMed  Google Scholar 

  • Gyngell ML (1988) The application of steady-state free precession in rapid 2DFT NMR imaging: FAST and CE-FAST sequences. Magn Reson Imaging 6:415–419

    Article  CAS  PubMed  Google Scholar 

  • Gyngell ML (1989) The steady-state signals in short-repetition-time sequences. J Magn Reson 81:474–483

    CAS  Google Scholar 

  • Haase A, Frahm J, Matthaei D, Hänicke W, Merboldt K-D (1986) FLASH imaging. Rapid NMR imaging using low flip-angle pulses. J Magn Reson 67:258–266

    CAS  Google Scholar 

  • Hall DA, Haggard MP, Akeroyd MA, Palmer AR, Summerfield AQ, Elliott MR, Gurney EM, Bowtell RW (1999) “Sparse” temporal sampling in auditory fMRI. Hum Brain Mapp 7:213–223

    Article  CAS  PubMed  Google Scholar 

  • Haselgrove JC, Moore JR (1996) Correction for Distortion of echo-planar images used to calculate the apparent diffusion coefficient. Magn Reson Med 36:960–964

    Article  CAS  PubMed  Google Scholar 

  • Hennel F, Girard F, Loenneker T (1999) “Silent” MRI with soft gradient pulses. Magn Reson Med 42:6–10

    Article  CAS  PubMed  Google Scholar 

  • Hennig J, Nauerth A, Friedburg H (1986) RARE imaging: a fast imaging method for clinical MR. Magn Reson Med 3:823–833

    Article  CAS  PubMed  Google Scholar 

  • Hoogenraad FGC, Pouwels PJW, Hofman MBM, Reichenbach JR, Sprenger M, Haacke EM (2001) Quantitative differentiation between BOLD models in fMRI. Magn Reson Med 45:233–246

    Article  CAS  PubMed  Google Scholar 

  • Hoult DI (2000) Sensitivity and power deposition in a high-field imaging experiment. J Magn Reson Imaging 12:46–67

    Article  CAS  PubMed  Google Scholar 

  • Hutton C, Bork A, Josephs O, Deichmann R, Ashburner J, Turner R (2002) Image distortion correction in fMRI: a quantitative evaluation. Neuroimage 16:217–240

    Article  PubMed  Google Scholar 

  • Irarrazabal P, Nishimura DG (1995) Fast 3-dimensional magnetic-resonance-imaging. Magn Reson Med 33:656–662

    Article  CAS  PubMed  Google Scholar 

  • Jezzard P, Balaban RS (1995) Correction for geometric distortion in echo-planar images from B-0 field variations. Magn Reson Med 34:65–73

    Article  CAS  PubMed  Google Scholar 

  • Jezzard P, Clare S (1999) Sources of distortion in functional MRI data. Hum Brain Mapp 8:80–85

    Article  CAS  PubMed  Google Scholar 

  • Jovicich J, Norris DG (1999) Functional MRI of the human brain with GRASE-based BOLD contrast. Magn Reson Med 41:871–876

    Article  CAS  PubMed  Google Scholar 

  • Kaiser R, Bartholdi E, Ernst RR (1974) Diffusion and field-gradient effects in NMR Fourier spectroscopy. J Chem Phys 60:2966–2979

    Article  CAS  Google Scholar 

  • Krüger G, Glover GH (2001) Physiological noise in oxygenation-sensitive magnetic resonance imaging. Magn Reson Med 46:631–637

    Article  PubMed  Google Scholar 

  • Lai S, Glover GH (1998) Three-dimensional spiral fMRI technique: a comparison with 2D spiral acquisition. Magn Reson Med 39:68–78

    Article  CAS  PubMed  Google Scholar 

  • Larkman DJ, Hajnal JV, Herlihy AH, Coutts GA, Young IR, Ehnholm G (2001) Use of multicoil arrays for separation of signal from multiple slices simultaneously excited. J Magn Reson Imaging 13:313–317

    Article  CAS  PubMed  Google Scholar 

  • Le Roux P (2002) Non-CPMG fast spin echo with full signal. J Magn Reson 155:278–292

    Article  CAS  PubMed  Google Scholar 

  • Lee JH, Dumoulin SO, Saritas EU, Glover GH, Wandell BA, Nishimura DG, Pauly JM (2008) Full-brain coverage and high-resolution Imaging capabilities of passband b-SSFP fMRI at 3T. Magn Reson Med 59:1099–1110

    Article  PubMed Central  PubMed  Google Scholar 

  • Liu G, Sobering G, Duyn J, Moonen CT (1993a) A functional MRI technique combining principles of echo-shifting with a train of observations (PRESTO). Magn Reson Med 30:764–768

    Article  CAS  PubMed  Google Scholar 

  • Liu G, Sobering G, Olson AW, van Gelderen P, Moonen CTW (1993b) fast echo-shifted gradient-recalled MRI: combining a short repetition time with variable T2* weighting. Magn Reson Med 30:68–75

    Article  CAS  PubMed  Google Scholar 

  • Loenneker T, Hennel F, Hennig J (1996) Multislice interleaved excitation cycles (MUSIC): an efficient gradient-echo technique for functional MRI. Magn Reson Med 35:870–874

    Article  CAS  PubMed  Google Scholar 

  • Luo Y, de Graaf RA, De la Barre L, Tannus A, Garwood M (2001) BISTRO: an outer-volume suppression method that tolerates RF field inhomogeneity. Magn Reson Med 45:1095–1102

    Article  CAS  PubMed  Google Scholar 

  • Lustig M, Donoho D, Pauly JM (2007) Sparse MRI: the application of compressed sensing for rapid MR imaging. Magn Reson Med 58:1182–1195

    Article  PubMed  Google Scholar 

  • Mansfield P (1977) Multi-planar image formation using NMR spin echoes. J Phys C 10:L55–L58

    Article  CAS  Google Scholar 

  • Mansfield P (1984) Spatial mapping of the chemical shift in NMR. Magn Reson Med 1:370–386

    Article  CAS  PubMed  Google Scholar 

  • Mansfield P, Howseman AM, Ordidge RJ (1989) Volumar imaging using Nmr spin echoes—echo-volumar imaging (EVI) At 0.1-T. J Phys E-Sci Instrum 22:324–330

    Article  Google Scholar 

  • McKinnon GC (1993) Ultrafast interleaved gradient-echo-planar imaging on a standard scanner. Magn Reson Med 30:609–616

    Article  CAS  PubMed  Google Scholar 

  • Menon RS, Ogawa S, Tank DW, Uğurbil K (1993) 4 Tesla gradient recalled echo characteristics of photic stimulation-induced signal changes in the human primary visual cortex. Magn Reson Med 30:380–386

    Article  CAS  PubMed  Google Scholar 

  • Meyer CH, Pauly JM, Macovski A, Nishimura DG (1990) Simultaneous spatial and spectral selective excitation. Magn Reson Med 15:287–304

    Article  CAS  PubMed  Google Scholar 

  • Meyer CH, Hu BS, Nishimura DG, Macovski A (1992) Fast spiral coronary-artery imaging. Magn Reson Med 28:202–213

    Article  CAS  PubMed  Google Scholar 

  • Miller KL, Hargreaves BA, Lee J, Ress D, de Charms RC, Pauly JM (2003) Functional brain imaging using a blood oxygenation sensitive steady state. Magn Reson Med 50:675–683

    Article  PubMed  Google Scholar 

  • Miller KL, Smith SM, Jezzard P, Pauly JM (2006) High-resolution fMRI at 1.5T using balanced SSFP. Magn Reson Med 55:161–170

    Article  CAS  PubMed  Google Scholar 

  • Miller KL, Smith SM, Jezzard P, Wiggins GC, Wiggins CJ (2007) Signal and noise characteristics of SSFPFMRI: a comparison with GRE at multiple field strengths. Neuroimage 37:1227–1236

    Article  PubMed  Google Scholar 

  • Moeller S, Yacoub E, Olman CA, Auerbach E, Strupp J, Harel N, Uğurbil K (2010) Multiband multislice GE-EPI at 7 Tesla, with 16-fold acceleration using partial parallel imaging with application to high spatial and temporal whole-brain FMRI. Magn Reson Med 63:1144–1153

    Article  PubMed Central  PubMed  Google Scholar 

  • Morgan PS, Bowtell RW, McIntyre DJO, Worthington BS (2004) Correction of spatial distortion in EPI due to inhomogeneous static magnetic fields using the reversed gradient method. J Magn Reson Imaging 19:499–507

    Article  PubMed  Google Scholar 

  • Mugler JP (1999) Improved three-dimensional GRASE imaging with the SORT phase-encoding strategy. J Magn Reson Imaging 9:604–612

    Article  PubMed  Google Scholar 

  • Norris DG (2007) Selective parity RARE imaging. Magn Reson Med 58:643–649

    Article  PubMed  Google Scholar 

  • Norris DG, Börnert P, Reese T, Leibfritz D (1992) On the application of ultra-fast RARE experiments. Magn Reson Med 27:142–164

    Article  CAS  PubMed  Google Scholar 

  • Norris DG, Zysset S, Mildner T, Wiggins CJ (2002) An investigation of the value of spin-echo based fMRI using a stroop colour-word matching task and EPI at 3 Tesla. Neuroimage 15:719–726

    Article  PubMed  Google Scholar 

  • Ogawa S, Lee T, Nayak AS, Glynn P (1990a) Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields. Magn Reson Med 14:68–78

    Article  CAS  PubMed  Google Scholar 

  • Ogawa S, Lee TM, Kay AR, Tank, DW (1990b) Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci U S A 87:9868–9872

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Ohliger MA, Grant AK, Sodickson DK (2003) Ultimate intrinsic signal-to-noise ratio for parallel MRI: electromagnetic field considerations. Magn Reson Med 50:1018–1030

    Article  PubMed  Google Scholar 

  • Ordidge RJ, Gorell JM, Deniau JC, Knight RA, Helpern JA (1994) Assessment of relative brain iron concentrations using T2-weighted and T2*-weighted MRI at 3 Tesla. Magn Reson Med 32:335–341

    Article  CAS  PubMed  Google Scholar 

  • Oshio K, Feinberg DA (1991) GRASE (gradient- and spin-echo) imaging: a novel fast MRI technique. Magn Reson Med 20:344–349

    Article  CAS  PubMed  Google Scholar 

  • Poser BA, Norris DG (2007) Fast spin echo sequences for BOLD functional MRI. Magn Reson Mater Phys 20:11–17

    Article  Google Scholar 

  • Poser BA, Norris DG (2009a) Investigating the benefits of multi-echo EPI for fMRI at 7 T. Neuroimage 45:1162–1172

    Article  PubMed  Google Scholar 

  • Poser BA, Norris DG (2009b) 3D single-shot VASO using a Maxwell gradient compensated GRASE sequence. Magn Reson Med 62:255–262

    Article  PubMed  Google Scholar 

  • Poser BA, Versluis MJ, Hoogduin JM, Norris DG (2006) BOLD contrast sensitivity enhancement and artifact reduction with multiecho EPI: parallel-acquired inhomogeneity-desensitized fMRI. Magn Reson Med 55:1227–1235

    Article  PubMed  Google Scholar 

  • Poser BA, Koopmans PJ, Witzel T, Wald LL, Barth M (2010) Three dimensional echo-planar imaging at 7 Tesla. Neuroimage 51:261–266

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Posse S, Tedeschi G, Risinger R, Ogg R, Le Bihan D (1995) High speed 1H spectroscopic imaging in human brain by echo planar spatial-spectral encoding. Magn Reson Med 33:34–40

    Article  CAS  PubMed  Google Scholar 

  • Posse S, Wiese S, Gembris D, Mathiak K, Kessler C, Grosse-Ruyken ML, Elghahwagi B, Richards T, Dager SR, Kiselev VG (1999) Enhancement of BOLD-contrast sensitivity by single-shot multi-echo functional MR imaging. Magn Reson Med 42:87–97

    Article  CAS  PubMed  Google Scholar 

  • Preibisch C, Pilatus U, Bunke J, Hoogenraad F, Zanella F, Lanfermann H (2003) Functional MRI using sensitivity-encoded echo planar imaging (SENSE-EPI). Neuroimage 19:412–421

    Article  PubMed  Google Scholar 

  • Prüssmann KP, Weiger M, Scheidegger MB, Bösiger P (1999) SENSE: sensitivity encoding for fast MRI. Magn Reson Med 42:952–962

    Article  Google Scholar 

  • Reichenbach JR, Venkatesan R, Yablonskiy DA, Thompson MR, Lai S, Haacke EM (1997) Theory and application of static field inhomogeneity effects in gradient-echo imaging. J Magn Reson Imaging 7:266–279

    Article  CAS  PubMed  Google Scholar 

  • Remmele S, Dahnke H, Flacke S, Soehle M, Wenningmann I, Kovacs A, Traber F, Muller A, Willinek WA, Konig R, Clusmann H, Gieseke J, Schild HH, Murtz P (2010) Quantification of the magnetic resonance signal response to dynamic (C)O-2-enhanced imaging in the brain at 3 T: R-2* BOLD vs. balanced SSFP. J Magn Reson Imaging 31:1300–1310

    Article  PubMed  Google Scholar 

  • Scheffler K, Seifritz E, Bilecen D, Venkatesan R, Hennig J, Deimling M, Haacke EM (2001) Detection of BOLD changes by means of a frequency-sensitive true FISP technique: preliminary results. NMR Biomed 14:490–496

    Article  CAS  PubMed  Google Scholar 

  • Schick F (1997) SPLICE: sub-second diffusion-sensitive MR imaging using a modified fast spin-echo acquisition mode. Magn Reson Med 38:638–644

    Article  CAS  PubMed  Google Scholar 

  • Schmidt CF, Zaehle T, Meyer M, Geiser E, Boesiger P, Jancke L (2008) Silent and continuous fMRI scanning differentially modulate activation in an auditory language comprehension task. Hum Brain Mapp 29:46–56

    Article  PubMed  Google Scholar 

  • Schmiedeskamp H, Newbould RD, Pisani LJ, Skare S, Glover GH, Pruessmann KP, Bammer R (2010) Improvements in parallel imaging accelerated functional MRI using multiecho echo-planar imaging. Magn Reson Med 63:959–969

    Article  PubMed Central  PubMed  Google Scholar 

  • Schmitt F, Stehling MK, Turner R (1998) Echo-planar imaging theory, technique and application. Springer, Berlin

    Book  Google Scholar 

  • Schmitter S, Diesch E, Amann M, Kroll A, Moayer M, Schad LR (2008) Silent echo-planar imaging for auditory fMRI. Magn Reson Mater Phys 21:317–325

    Article  CAS  Google Scholar 

  • Schwarzbauer C, Davis MH, Rodd JM, Johnsrude I (2006) Interleaved silent steady state (ISSS) imaging: a new sparse imaging method applied to auditory fMRI. Neuroimage 29:774–782

    Article  PubMed  Google Scholar 

  • Seifritz E, Di Salle F, Esposito F, Herdener M, Neuhoff JG, Scheffler K (2006) Enhancing BOLD response in the auditory system by neurophysiologically tuned fMRI sequence. Neuroimage 29:1013–1022

    Article  PubMed  Google Scholar 

  • Sodickson DK, Griswold MA, Jakob PM (1999) SMASH imaging. Magn Reson Imaging Clin N Am 7:237–254, vii–viii

    CAS  PubMed  Google Scholar 

  • Speck O, Hennig J (1998) Functional imaging by I-0- and T-2*-parameter mapping using multi-image EPI. Magn Reson Med 40:243–248

    Article  CAS  PubMed  Google Scholar 

  • Stenger VA, Boada FE, Noll DC (2000) Three-dimensional tailored RF pulses for the reduction of susceptibility artifacts in T-2*-weighted functional MRI. Magn Reson Med 44:525–531

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Turner R, Howseman A, Rees GE, Josephs O, Friston K (1998) Functional magnetic resonance imaging of the human brain: data acquisition and analysis. Exp Brain Res 123:5–12

    Article  CAS  PubMed  Google Scholar 

  • Weiskopf N, Klose U, Birbaumer N, Mathiak K (2005) Single-shot compensation of image optimization using multi-echo EPI distortions and BOLD contrast for real-time fMRI. Neuroimage 24:1068–1079

    Article  PubMed  Google Scholar 

  • Wiesinger F, Boesiger P, Pruessmann KP (2004) Electrodynamics and ultimate SNR in parallel MR imaging. Magn Reson Med 52:376–390

    Article  PubMed  Google Scholar 

  • Wild JM, Martin, W.R.W., Allen PS (2002) Multiple gradient echo sequence optimized for rapid, single-scan mapping of R-2(*) at high B-0. Magn Reson Med 48:867–876

    Article  PubMed  Google Scholar 

  • Wu G, Li SJ (2005) Theoretical noise model for oxygenation-sensitive magnetic resonance imaging. Magn Reson Med 53:1046–1054

    Article  PubMed  Google Scholar 

  • Yacoub E, Duong TQ, Van de Moortele PF, Lindquist M, Adriany G, Kim SG, Uğurbil K, Hu X (2003) Spin-echo fMRI in humans using high spatial resolutions and high magnetic fields. Magn Reson Med 49:655–664

    Article  PubMed  Google Scholar 

  • Yacoub E, Van de Moortele PF, Shmuel A, Uğurbil K (2005) Signal and noise characteristics of Hahn SE and GE BOLD fMRI at 7 T in humans. Neuroimage 24:738–750

    Article  PubMed  Google Scholar 

  • Yacoub E, Shmuel A, Logothetis N, Uğurbil K (2007) Robust detection of ocular dominance columns in humans using Hahn Spin Echo BOLD functional MRI at 7 Tesla. Neuroimage 37:1161–1177

    Article  PubMed Central  PubMed  Google Scholar 

  • Yang YH, Glover GH, vanGelderen P, Mattay VS, Santha AKS, Sexton RH, Ramsey NF, Moonen CTW, Weinberger DR, Frank JA, Duyn JH (1996) Fast 3D functional magnetic resonance imaging at 1.5 T with spiral acquisition. Magn Reson Med 36:620–626

    Article  CAS  PubMed  Google Scholar 

  • Yip CY, Fessler JA, Noll DC (2006) Advanced three-dimensional tailored RF pulse for signal recovery in T-2*-weighted functional magnetic resonance imaging. Magn Reson Med 56:1050–1059

    Article  PubMed  Google Scholar 

  • Zaitsev M, Hennig J, Speck O (2004) Point spread function mapping with parallel imaging techniques and high acceleration factors: fast, robust, and flexible method for echo-planar imaging distortion correction. Magn Reson Med 52:1156–1166

    Article  CAS  PubMed  Google Scholar 

  • Zeng H, Constable RT (2002) Image distortion correction in EPI: comparison of field mapping with point spread function mapping. Magn Reson Med 48:137–146

    Article  PubMed  Google Scholar 

  • Zhong K, Leupold J, Hennig J, Speck O (2007) Systematic investigation of balanced steady-state free precession for functional MRI in the human visual cortex at 3 Tesla. Magn Reson Med 57:67–73

    Article  PubMed  Google Scholar 

  • Zur Y, Wood ML, Neuringer LJ (1990) Motion-insensitive, steady-state free precession imaging. Magn Reson Med 16:444–459

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to David G. Norris .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer New York

About this chapter

Cite this chapter

Norris, D. (2015). Pulse Sequences for fMRI. In: Uludag, K., Ugurbil, K., Berliner, L. (eds) fMRI: From Nuclear Spins to Brain Functions. Biological Magnetic Resonance, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7591-1_7

Download citation

Publish with us

Policies and ethics