Skip to main content

Anterior Lumbar Interbody Fusion

  • Chapter
Spondylolisthesis

Abstract

Anterior lumbar interbody fusion (ALIF) was first reported in 1906 and is currently an acceptable option for surgical treatment of spondylolisthesis. A careful preoperative evaluation is critical, as most complications are approach related. Both retroperitoneal and transperitoneal approaches are utilized for exposing the lower lumbar levels most commonly associated with spondylolisthesis. A wide variety of options are available for the interbody graft, including autogenous bone grafts and titanium cages, as well as graft adjuncts such as bone morphogenetic protein (rhBMP-2). Both radiographic results and health related quality of life (HRQOL) studies have established ALIF as a reliable procedure for the treatment of spondylolisthesis. Known complications of ALIF include vascular damage, injury to peritoneal viscera, ileus, and retrograde ejaculation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

ALIF:

Anterior lumbar interbody fusion

HRQOL:

Health related quality of life

PLIF:

Posterior lumbar interbody fusion

RE:

Retrograde ejaculation

rhBMP-2:

Recombinant human bone morphogenetic protein-2

TLIF:

Transforaminal lumbar interbody fusion

References

  1. Gjessing MH. Osteoplastic anterior fusion of the lower lumbar spine in spondylolisthesis, localized spondylosis, and tuberculous spondylitis. Acta Orthop. 1951;20(3):200–13.

    Article  CAS  Google Scholar 

  2. Capener N. Spondylolisthesis. Br J Surg. 1932;19(75):374–86.

    Article  Google Scholar 

  3. Burns B. An operation for spondylolisthesis. Lancet. 1933;1:1233–9.

    Article  Google Scholar 

  4. Iwahara T. A new method of vertebral body fusion. Surg Jpn. 1944;8:271–87.

    Google Scholar 

  5. Lane JD, Moore ES. Transperitoneal approach to the intervertebral disc in the lumbar area. Ann Surg. 1948;127(3):537–51.

    Article  PubMed Central  PubMed  Google Scholar 

  6. Harmon PH. Results from the treatment of sciatica due to lumbar disc protrusion. Am J Surg. 1950;80(6):829–40.

    Article  CAS  PubMed  Google Scholar 

  7. Hodgson AR, Stock FE. Anterior spinal fusion a preliminary communication on the radical treatment of pott’s disease and pott’s paraplegia. Br J Surg. 1956;44(185):266–75.

    Article  CAS  PubMed  Google Scholar 

  8. Cloward RB. Lesions of the intervertebral disks and their treatment by interbody fusion methods. The painful disk. Clin Orthop Relat Res. 1963;27:51–77.

    CAS  PubMed  Google Scholar 

  9. Crock HV. Anterior lumbar interbody fusion: indications for its use and notes on surgical technique. Clin Orthop Relat Res. 1982;165:157–63.

    PubMed  Google Scholar 

  10. Fujimaki A, Crock HV, Bedbrook GM. The results of 150 anterior lumbar interbody fusion operations performed by two surgeons in Australia. Clin Orthop Relat Res. 1982;165:164–7.

    PubMed  Google Scholar 

  11. Kuslich SD, Ulstrom CL, Griffith SL, Ahern JW, Dowdle JD. The Bagby and Kuslich method of lumbar interbody fusion. History, techniques, and 2-year follow-up results of a United States prospective, multicenter trial. Spine. 1998;23(11):1267–78. Discussion 1279.

    Article  CAS  PubMed  Google Scholar 

  12. Lekovic GP, Han PP, Kenny KJ, Dickman CA. Bone dowels in anterior lumbar interbody fusion. J Spinal Disord Tech. 2007;20(5):374–9.

    Article  PubMed  Google Scholar 

  13. Bridwell KH, Dewald RL. The textbook of spinal surgery. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins Health; 2011.

    Google Scholar 

  14. Djurasovic M, Bratcher KR, Glassman SD, Dimar JR, Carreon LY. The effect of obesity on clinical outcomes after lumbar fusion. Spine. 2008;33(16):1789–92.

    Article  PubMed  Google Scholar 

  15. Mogannam A, Bianchi C, Chiriano J, Patel S, Teruya TH, Lum SS, et al. Effects of prior abdominal surgery, obesity, and lumbar spine level on anterior retroperitoneal exposure of the lumbar spine anterior retroperitoneal exposure of the spine. Arch Surg. 2012;147(12):1130–4.

    Article  PubMed  Google Scholar 

  16. Patel N, Bagan B, Vadera S, Maltenfort MG, Deutsch H, Vaccaro AR, et al. Obesity and spine surgery: relation to perioperative complications. J Neurosurg Spine. 2007;6(4):291–7.

    Article  PubMed  Google Scholar 

  17. Sasso RC, Kenneth Burkus J, LeHuec J-C. Retrograde ejaculation after anterior lumbar interbody fusion: transperitoneal versus retroperitoneal exposure. Spine. 2003;28(10):1023–6.

    PubMed  Google Scholar 

  18. O’Dowd J, Mullholland R, Harris M. BAK cage: Nottingham results. San Francisco: North American Spine Society; 1998.

    Google Scholar 

  19. Ray CD. Threaded titanium cages for lumbar interbody fusions. Spine. 1997;22(6):667–79. Discussion 679–680.

    Article  CAS  PubMed  Google Scholar 

  20. Stauffer RN, Coventry MB. Anterior interbody lumbar spine fusion analysis of mayo clinic series. J Bone Joint Surg Am. 1972;54(4):756–68.

    CAS  PubMed  Google Scholar 

  21. Thalgott JS, Fogarty ME, Giuffre JM, Christenson SD, Epstein AK, Aprill C. A prospective, randomized, blinded, single-site study to evaluate the clinical and radiographic differences between frozen and freeze-dried allograft when used as part of a circumferential anterior lumbar interbody fusion procedure. Spine. 2009;34(12):1251–6.

    Article  PubMed  Google Scholar 

  22. Brantigan JW, Cunningham BW, Warden K, McAfee PC, Steffee AD. Compression strength of donor bone for posterior lumbar interbody fusion. Spine. 1993;18(9):1213–21.

    Article  CAS  PubMed  Google Scholar 

  23. Burkus JK, Gornet MF, Dickman CA, Zdeblick TA. Anterior lumbar interbody fusion using rhBMP-2 with tapered interbody cages. J Spinal Disord Tech. 2002;15(5):337–49.

    Article  PubMed  Google Scholar 

  24. Slosar PJ, Josey R, Reynolds J. Accelerating lumbar fusions by combining rhBMP-2 with allograft bone: a prospective analysis of interbody fusion rates and clinical outcomes. Spine J. 2007;7(3):301–7.

    Article  PubMed  Google Scholar 

  25. McKay WF, Peckham SM, Badura JM. A comprehensive clinical review of recombinant human bone morphogenetic protein-2 (INFUSE® bone graft). Int Orthop. 2007;31(6):729–34.

    Article  PubMed Central  PubMed  Google Scholar 

  26. Cahill KS, Chi JH, Day A, Claus EB. Prevalence, complications, and hospital charges associated with use of bone-morphogenetic proteins in spinal fusion procedures. JAMA. 2009;302(1):58–66.

    Article  CAS  PubMed  Google Scholar 

  27. Lubelski D, Abdullah KG, Steinmetz MP, Alvin MD, Amy SN, Chakka S, et al. Adverse events with the use of rhBMP-2 in thoracolumbar and lumbar spine fusions: a nine year institutional analysis. J Spinal Disord Tech. 2013;1.

    Google Scholar 

  28. Mroz TE, Wang JC, Hashimoto R, Norvell DC. Complications related to osteobiologics use in spine surgery: a systematic review. Spine. 2010;35(9 Suppl):S86–104.

    Article  PubMed  Google Scholar 

  29. Christensen FB, Bünger CE. Retrograde ejaculation after retroperitoneal lower lumbar interbody fusion. Int Orthop. 1997;21(3):176–80.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  30. Jiang S-D, Chen J-W, Jiang L-S. Which procedure is better for lumbar interbody fusion: anterior lumbar interbody fusion or transforaminal lumbar interbody fusion? Arch Orthop Trauma Surg. 2012;132(9):1259–66.

    Article  PubMed  Google Scholar 

  31. Kalb S, Perez-Orribo L, Kalani MYS, Snyder LA, Martirosyan NL, Burns K, et al. The influence of common medical conditions on the outcome of anterior lumbar interbody fusion. J Spinal Disord Tech. 2013;1

    Google Scholar 

  32. Weinstein JN, Lurie JD, Tosteson TD, Zhao W, Blood EA, Tosteson AN, Birkmeyer N, Herkowitz H, Longley M, Lenke L, Emery S, Hu SS. Surgical compared with nonoperative treatment for lumbar degenerative spondylolisthesis. Four-year results in the spine patient outcomes research trial (SPORT) randomized and observational cohorts. J Bone Joint Surg Am. 2009;91(6):1295.

    Article  PubMed Central  PubMed  Google Scholar 

  33. Weinstein JN, Lurie JD, Tosteson TD, Tosteson AN, Blood E, Abdu WA, et al. Surgical versus non-operative treatment for lumbar disc herniation: four-year results for the spine patient outcomes research trial (SPORT). Spine. 2008;33(25):2789.

    Article  PubMed Central  PubMed  Google Scholar 

  34. Weinstein JN, Tosteson TD, Lurie JD, Tosteson A, Blood E, Herkowitz H, et al. Surgical versus nonoperative treatment for lumbar spinal stenosis four-year results of the spine patient outcomes research trial. Spine. 2010;35(14):1329–38.

    PubMed Central  PubMed  Google Scholar 

  35. Takahashi K, Kitahara H, Yamagata M, Murakami M, Takata K, Miyamoto K, et al. Long-term results of anterior interbody fusion for treatment of degenerative spondylolisthesis. Spine. 1990;15(11):1211–5.

    Article  CAS  PubMed  Google Scholar 

  36. Riouallon G, Lachaniette C-H-F, Poignard A, Allain J. Outcomes of anterior lumbar interbody fusion in low-grade isthmic spondylolisthesis in adults: a continuous series of 65 cases with an average follow-up of 6.6years. Orthop Traumatol Surg Res. 2013;99(2):155–61.

    Article  CAS  PubMed  Google Scholar 

  37. Ohtori S, Koshi T, Yamashita M, Takaso M, Yamauchi K, Inoue G, et al. Single-level instrumented posterolateral fusion versus non-instrumented anterior interbody fusion for lumbar spondylolisthesis: a prospective study with a 2-year follow-up. J Orthop Sci. 2011;16(4):352–8.

    Article  PubMed  Google Scholar 

  38. Min J-H, Jang J-S, Lee S-H. Comparison of anterior- and posterior-approach instrumented lumbar interbody fusion for spondylolisthesis. J Neurosurg Spine. 2007;7(1):21–6.

    Article  PubMed  Google Scholar 

  39. Kim J-S, Lee K-Y, Lee S-H, Lee H-Y. Which lumbar interbody fusion technique is better in terms of level for the treatment of unstable isthmic spondylolisthesis? Clinical article. J Neurosurg Spine. 2010;12(2):171–7.

    Article  PubMed  Google Scholar 

  40. Polly Jr DW, Glassman SD, Schwender JD, Shaffrey CI, Branch C, Burkus JK, et al. SF-36 PCS benefit-cost ratio of lumbar fusion comparison to other surgical interventions: a thought experiment. Spine. 2007;32(11):S20–6.

    Article  PubMed  Google Scholar 

  41. Tosteson ANA, Tosteson TD, Lurie JD, Abdu W, Herkowitz H, Andersson G, et al. Comparative effectiveness evidence from the spine patient outcomes research trial: surgical versus nonoperative care for spinal stenosis, degenerative spondylolisthesis, and intervertebral disc herniation. Spine. 2011;36(24):2061–8.

    Article  PubMed Central  PubMed  Google Scholar 

  42. Inamasu J, Guiot BH. Vascular injury and complication in neurosurgical spine surgery. Acta Neurochir (Wien). 2006;148(4):375–87.

    Article  CAS  Google Scholar 

  43. Than KD, Wang AC, Rahman SU, Wilson TJ, Valdivia JM, Park P, et al. Complication avoidance and management in anterior lumbar interbody fusion. Neurosurg Focus. 2011;31(4):E6.

    Article  PubMed  Google Scholar 

  44. Brau SA, Delamarter RB, Schiffman ML, Williams LA, Watkins RG. Left iliac artery thrombosis during anterior lumbar surgery. Ann Vasc Surg. 2004;18(1):48–51.

    Article  PubMed  Google Scholar 

  45. Quraishi NA, Konig M, Booker SJ, Shafafy M, Boszczyk BM, Grevitt MP, et al. Access related complications in anterior lumbar surgery performed by spinal surgeons. Eur Spine J. 2013;22 Suppl 1:S16–20.

    Article  PubMed  Google Scholar 

  46. Smith MW, Rahn KA, Shugart RM, Belschner CD, Stout KS, Cheng I. Comparison of perioperative parameters and complications observed in the anterior exposure of the lumbar spine by a spine surgeon with and without the assistance of an access surgeon. Spine J. 2011;11(5):389–94.

    Article  PubMed  Google Scholar 

  47. Quraishi NA, Konig M, Booker SJ, Shafafy M, Boszczyk BM, Grevitt MP, et al. Access related complications in anterior lumbar surgery performed by spinal surgeons. Eur Spine J. 2012;22(S1):16–20.

    Article  PubMed Central  Google Scholar 

  48. Sasso RC, Best NM, Mummaneni PV, Reilly TM, Hussain SM. Analysis of operative complications in a series of 471 anterior lumbar interbody fusion procedures. Spine. 2005;30(6):670–4.

    Article  PubMed  Google Scholar 

  49. Czerwein Jr JK, Thakur N, Migliori SJ, Lucas P, Palumbo M. Complications of anterior lumbar surgery. J Am Acad Orthop Surg. 2011;19(5):251–8.

    PubMed  Google Scholar 

  50. Santos ERG, Pinto MR, Lonstein JE, Denis F, Garvey TA, Perra JH, et al. Revision lumbar arthrodesis for the treatment of lumbar cage pseudoarthrosis: complications. J Spinal Disord Tech. 2008;21(6):418–21.

    Article  PubMed  Google Scholar 

  51. Schwender JD, Casnellie MT, Perra JH, Transfeldt EE, Pinto MR, Denis F, et al. Perioperative complications in revision anterior lumbar spine surgery: incidence and risk factors. Spine. 2009;34(1):87–90.

    Article  PubMed  Google Scholar 

  52. Carragee EJ, Mitsunaga KA, Hurwitz EL, Scuderi GJ. Retrograde ejaculation after anterior lumbar interbody fusion using rhBMP-2: a cohort controlled study. Spine J. 2011;11(6):511–6.

    Article  PubMed  Google Scholar 

  53. Lindley EM, McBeth ZL, Henry SE, Cooley R, Burger EL, Cain CMJ, et al. Retrograde ejaculation after anterior lumbar spine surgery. Spine. 2012;37(20):1785–9.

    Article  PubMed  Google Scholar 

  54. Tepper G, Rabbani R, Yousefzadeh M, Prince D. Quantitative assessment of retrograde ejaculation using semen analysis, comparison with a standardized qualitative questionnaire, and investigating the impact of rhBMP-2. Spine. 2013;38(10):841–5.

    Article  PubMed  Google Scholar 

  55. Shaffrey CI, Smith JS. Editorial: recombinant human bone morphogenetic protein-2. J Neurosurg Spine. 2013;18(2):109–10. Discussion 110–111.

    Article  PubMed  Google Scholar 

  56. Ghanayem AJ, Santaniello J. Anterior lumbar interbody fusion with recombinant human bone morphogenetic protein-2 and retrograde ejaculation: results from a non-industry sponsored. Spine J. 2012;12(9):S4.

    Article  Google Scholar 

  57. Kang B-U, Choi W-C, Lee S-H, Jeon SH, Park JD, Maeng DH, et al. An analysis of general surgery-related complications in a series of 412 minilaparotomic anterior lumbosacral procedures: clinical article. J Neurosurg Spine. 2009;10(1):60–5.

    Article  PubMed  Google Scholar 

  58. Pappou IP, Papadopoulos EC, Sama AA, Girardi FP, Cammisa FP. Postoperative infections in interbody fusion for degenerative spinal disease. Clin Orthop Relat Res. 2006;443:120–8.

    Article  Google Scholar 

  59. Scaduto AA, Gamradt SC, Warren DY, Huang J, Delamarter RB, Wang JC. Perioperative complications of threaded cylindrical lumbar interbody fusion devices: anterior versus posterior approach. J Spinal Disord Tech. 2003;16(6):502–7.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jacob M. Buchowski M.D., M.S. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer Science+Business Media New York

About this chapter

Cite this chapter

Zhao, J., Gum, J.L., Dimar, J.R., Buchowski, J.M. (2015). Anterior Lumbar Interbody Fusion. In: Wollowick, A., Sarwahi, V. (eds) Spondylolisthesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7575-1_14

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-7575-1_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-7574-4

  • Online ISBN: 978-1-4899-7575-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics