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Characterization Methods for Oral Mucosal Drug Delivery

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Oral Mucosal Drug Delivery and Therapy

Part of the book series: Advances in Delivery Science and Technology ((ADST))

Abstract

Drug delivery across oral mucosal membranes has emerged as an excellent alternative for compounds that cannot be delivered orally. However, a standardized method to evaluate drug absorption across oral mucosal membranes, either in vitro or in vivo, still remains elusive. This chapter provides a comprehensive review of the current in vitro and in vivo methodologies employed in the literature for evaluating oral transmucosal absorption of compounds. The barrier function of oral mucosa along with the transport mechanisms is briefly reviewed. The methods to study drug absorption in vivo such as the buccal absorption test along with its refinements are discussed. In addition, a brief review of the present knowledge relating to various in vitro methods including the selection of suitable animal species, apparatus, and their limitations is given. Methods to test residence time, mucoadhesion, and drug release are also discussed in this chapter, together with a special emphasis on the use of buccal cell cultures as a means to study oral mucosal drug absorption. The need to conduct pharmacokinetic (PK) studies is also highlighted and discussed in the chapter.

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Acknowledgment

The authors gratefully acknowledge the assistance of pharmacy student, Tam Nguyen, who completed an Advanced Pharmacy Practice Experience rotation with Dr. Kolli at California Northstate University.

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Authors and Affiliations

  1. College of Pharmacy, California Health Sciences University, 120 N Clovis Ave, 95612, Clovis, CA, USA

    Chandra Sekhar Kolli

  2. College of Pharmacy, California Northstate University, 9700 West Taron Drive, 95757, Elk Grove, CA, USA

    Indiran Pather

Authors
  1. Chandra Sekhar Kolli
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  2. Indiran Pather
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Corresponding author

Correspondence to Chandra Sekhar Kolli .

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Editors and Affiliations

  1. Ulti Pharmaceuticals Ltd., Hamilton, New Zealand

    Michael J. Rathbone

  2. Hacettepe University, Faculty of Pharmacy, Ankara, Turkey

    Sevda Senel

  3. California Northstate University, College of Pharmacy, Elk Grove, California, USA

    Indiran Pather

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© 2015 Controlled Release Society

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Kolli, C., Pather, I. (2015). Characterization Methods for Oral Mucosal Drug Delivery. In: Rathbone, M., Senel, S., Pather, I. (eds) Oral Mucosal Drug Delivery and Therapy. Advances in Delivery Science and Technology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7558-4_6

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