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Chemical Methods for Enhancing Oral Mucosal Delivery

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Oral Mucosal Drug Delivery and Therapy

Part of the book series: Advances in Delivery Science and Technology ((ADST))

Abstract

The passage of many drugs through the mucosa of the oral cavity is inherently slow. Therefore, the enhancement of permeation, to an extent that allows the delivery of a suitable dose of the drug, is of interest. One approach to achieve this objective is the use of chemicals that promote delivery of the drug across the mucosa. This chapter reviews the different classes of compounds that may be of utility in this regard. A broad view is taken of the concept of “chemical methods for enhancing delivery.” Thus, chemicals which assist in retaining the dosage form to the mucosa for an extended time, thereby allowing a longer time for drug permeation, are included in this discussion, as are effervescent agents.

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Acknowledgment

The authors gratefully acknowledge the assistance of pharmacy student, Grant Ayvazyan, who completed an Advanced Pharmacy Practice Experience rotation with Dr. Pather.

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Authors and Affiliations

  1. College of Pharmacy, California Northstate University, 9700 West Taron Drive, 95757, Elk Grove, CA, USA

    Indiran Pather

  2. College of Pharmacy, California Health Sciences University, 120 N. Clovis Ave, 95612, Clovis, CA, USA

    Chandra Sekhar Kolli

Authors
  1. Indiran Pather
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  2. Chandra Sekhar Kolli
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Correspondence to Indiran Pather .

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Editors and Affiliations

  1. Ulti Pharmaceuticals Ltd., Hamilton, New Zealand

    Michael J. Rathbone

  2. Hacettepe University, Faculty of Pharmacy, Ankara, Turkey

    Sevda Senel

  3. California Northstate University, College of Pharmacy, Elk Grove, California, USA

    Indiran Pather

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Pather, I., Kolli, C. (2015). Chemical Methods for Enhancing Oral Mucosal Delivery. In: Rathbone, M., Senel, S., Pather, I. (eds) Oral Mucosal Drug Delivery and Therapy. Advances in Delivery Science and Technology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7558-4_3

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