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Oral Mucosal Drug Delivery and Therapy pp 225–245Cite as

Medical Devices for Oral Mucosal Applications

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Part of the book series: Advances in Delivery Science and Technology ((ADST))

Abstract

This chapter discusses the opportunities offered by medical devices as supportive care for oromucosal pathologies. There are still many unmet needs in the treatment of these pathologies, one such example is oral mucositis caused by cancer chemo-radiotherapy. This condition does not have a satisfactory treatment at the present time, yet it is so disabling to the patient that it may eventually lead to the discontinuation of cancer therapy.

After a brief introduction that includes definitions and relevant regulations, the oral conditions that can be treated with a medical device are considered, in particular mucositis, aphthae and xerostomia. In addition the mechanisms of action by which medical devices function are reviewed and a list of representative products available on the markets is included in the chapter. In the last section the results of authors’ ongoing research aimed at developing new improved class II medical devices are presented. These studies are currently focused on the development of suitable mucoadhesive vehicles (gels and in situ gelling spray), to be extemporaneously reconstituted with appropriate drugs or drug products, that are capable of assuring a prolonged contact with the damaged mucosa and prevent the detrimental removal effect of biological fluids.

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Author information

Authors and Affiliations

  1. Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100, Pavia, Italy

    Carla M. Caramella, Maria Cristina Bonferoni, Giuseppina Sandri, Eleonora Dellera, Silvia Rossi & Franca Ferrari

  2. Helsinn Healthcare S.A., Via Pian Scairolo 9, 6912, Lugano/Pazzallo, Switzerland

    Fabio Macchi

Authors
  1. Carla M. Caramella
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  2. Maria Cristina Bonferoni
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  3. Giuseppina Sandri
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  4. Eleonora Dellera
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  5. Silvia Rossi
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  6. Franca Ferrari
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  7. Fabio Macchi
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Corresponding author

Correspondence to Carla M. Caramella .

Editor information

Editors and Affiliations

  1. Ulti Pharmaceuticals Ltd., Hamilton, New Zealand

    Michael J. Rathbone

  2. Hacettepe University, Faculty of Pharmacy, Ankara, Turkey

    Sevda Senel

  3. California Northstate University, College of Pharmacy, Elk Grove, California, USA

    Indiran Pather

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© 2015 Controlled Release Society

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Caramella, C. et al. (2015). Medical Devices for Oral Mucosal Applications. In: Rathbone, M., Senel, S., Pather, I. (eds) Oral Mucosal Drug Delivery and Therapy. Advances in Delivery Science and Technology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7558-4_10

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