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Neurobiological Risk Factors and Predictors of Vulnerability and Resilience to PTSD

  • Chapter
Future Directions in Post-Traumatic Stress Disorder

Abstract

The risk of developing PTSD following a traumatic experience depends on several vulnerability factors that may be classified into three distinct categories: pre-traumatic, peri-traumatic, and posttraumatic vulnerability factors. Accordingly, while we attempted to create a profile of the high-risk PTSD patient, the following factors should be included, among others: small hippocampus, previously altered HPA axis, vulnerable genetic profile, associated body injury, increased post-trauma noradrenergic activity. Some protective factors have been identified and included, but are not limited to coping, resources (e.g., social support, self-esteem, optimism), and finding meaning. Finally, human beings are resilient and in general are able to cope with adverse situations. Therefore, discovering possible resilience factors may assist in identifying the patients at risk and may contribute to developing the strategies to prevent the development of PTSD.

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Author information

Authors and Affiliations

  1. Department of Psychiatry, Rambam Health Care Campus, Haifa, Israel

    Marina Bar-Shai M.D., Ph.D. & Ehud Klein M.D.

  2. Faculty of Medicine, Technion IIT, Haifa, Israel

    Marina Bar-Shai M.D., Ph.D. & Ehud Klein M.D.

Authors
  1. Marina Bar-Shai M.D., Ph.D.
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  2. Ehud Klein M.D.
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Correspondence to Ehud Klein M.D. .

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Editors and Affiliations

  1. Department of Psychology, University of Haifa, Haifa, Israel

    Marilyn P. Safir

  2. Department of Psychology, University of Haifa, Haifa, Israel

    Helene S. Wallach

  3. Department of Psychiatry and School of Gerontology, University of Southern California Institute for Creative Technologies, Los Angeles, California, USA

    Albert "Skip" Rizzo

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Bar-Shai, M., Klein, E. (2015). Neurobiological Risk Factors and Predictors of Vulnerability and Resilience to PTSD. In: Safir, M., Wallach, H., Rizzo, A. (eds) Future Directions in Post-Traumatic Stress Disorder. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7522-5_2

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