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Alzheimer Disease

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Abstract

Alzheimer disease (AD) is the most common form of dementia and neurodegenerative disease. Less than 1 % of AD is due to autosomal dominant genes: PSEN 1, PSEN 2, and APP. Susceptibility genes such as APOE contribute to risk in a far larger number of cases. Predictive testing is available for the autosomal dominant genes, but is not recommended for risk genes as they are neither necessary nor sufficient to cause AD. Genetic testing is complicated by capacity to consent, lack of treatment, the need to test an affected family member before predictive testing, and family disagreements about testing.

Keywords

  • Genetic Counselor
  • Alzheimer Disease
  • Amyloid Precursor Protein
  • Cerebral Amyloid Angiopathy
  • Mini Mental Status Exam

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Fig. 7.1

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Correspondence to Jill S. Goldman .

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Early onset familial Alzheimer disease (MOV 324698 kb)

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Goldman, J.S. (2015). Alzheimer Disease. In: Goldman, J. (eds) Genetic Counseling for Adult Neurogenetic Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7482-2_7

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