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Overview of the Dementias

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The dementias are a group of usually progressive conditions causing impairment in any cognitive domain and in activities of daily living. The most common causes of dementia is Alzheimer’s disease. Dementia may have associated motor symptoms that can develop before or after the cognitive dysfunction. This section reviews many of the genetic counseling issues, including complexity of family history with both sporadic and inherited forms of dementia, the clinical overlap between dementias, distinction between autosomal dominant and risk genes, determining the capacity to consent to genetic testing, and the impact of predictive testing for a fatal, untreatable disease.


  • Genetic Testing
  • Next Generation Sequencing
  • Exome Sequencing
  • Dementia Diagnosis
  • Genetic Counseling Session

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  • DOI: 10.1007/978-1-4899-7482-2_6
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  1. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders. 5th Edition: DSM-5.

    Google Scholar 

  2. HDSA. (1994). Guidelines for genetic testing. New York, NY: The Huntington’s Disease Society of America.

    Google Scholar 

  3. Quaid, K. A. (2011). Genetic counseling for frontotemporal dementias. Journal of Molecular Neuroscience, 45(3), 706–709.

    PubMed  CrossRef  Google Scholar 

  4. Fortea, J., Lladó, A., Clarimón, J., Lleó, A., Oliva, R., Peri, J., et al. (2011). PICOGEN: Five years experience with a genetic counselling program for dementia. Neurología, 26(3), 143–149.

    PubMed  CrossRef  Google Scholar 

  5. Hedera, P. (2001). Ethical principles and pitfalls of genetic testing for dementia. Journal of Geriatric Psychiatry and Neurology, 14(4), 213–221.

    PubMed  CrossRef  Google Scholar 

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Correspondence to Jill S. Goldman .

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© 2015 Springer Science+Business Media New York

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Goldman, J.S. (2015). Overview of the Dementias. In: Goldman, J. (eds) Genetic Counseling for Adult Neurogenetic Disease. Springer, Boston, MA.

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