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Parkinson Disease

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Genetic Counseling for Adult Neurogenetic Disease

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Abstract

Parkinson disease (PD), the second most-common neurodegenerative disease, is characterized by tremor, bradykinesia, and muscle rigidity. These characteristics, parkinsonism, may also be found in related diseases known as the Parkinson’s plus disorders and may be a component of numerous Mendelian conditions. The variety of inheritance patterns in familial parkinsonism includes autosomal dominant, autosomal recessive, autosomal dominant with reduced penetrance, and increased susceptibility due to risk genes. Additionally since PD is a common disorder, family history can be complicated by the co-occurrence of both the genetic and sporadic forms of the disease in the same pedigree.

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Author information

Authors and Affiliations

  1. Department of Genetics and Metabolism, University of Minnesota Medical Center, Fairview, 420 Delaware St SE (MMC 485), Minneapolis, MN, 55455, USA

    Matt Bower

  2. Department of Neurology, University of Minnesota Medical Center, Fairview, 420 Delaware St SE (MMC 206), Minneapolis, MN, 55455, USA

    Paul Tuite

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  1. Matt Bower
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  2. Paul Tuite
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Correspondence to Matt Bower .

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Editors and Affiliations

  1. Taub Institute, Columbia University Medical Center, New York, New York, USA

    Jill S. Goldman

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Parkinson’s disease Part 2 (MOV 190980 kb)

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Bower, M., Tuite, P. (2015). Parkinson Disease. In: Goldman, J. (eds) Genetic Counseling for Adult Neurogenetic Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7482-2_3

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