Abstract
Motor neuron disorders (MNDs) are a heterogeneous group of sporadic and hereditary neurologic diseases causing progressive degeneration of motor neurons. Molecular genetic testing is often essential for diagnosis of MNDs. Autosomal dominant, autosomal recessive, and X-linked inheritance patterns are all found in these disorders. This chapter focuses on hereditary spastic paraplegia, an upper motor neuron disease, Kennedy disease (SBMA), a lower motor neuron disease, and Lou Gehrig disease, amyotrophic lateral sclerosis (ALS) affecting both systems.
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© 2015 Springer Science+Business Media New York
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Schindler, A.B. (2015). Overview of Motor Neuron Diseases. In: Goldman, J. (eds) Genetic Counseling for Adult Neurogenetic Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7482-2_12
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DOI: https://doi.org/10.1007/978-1-4899-7482-2_12
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Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-7481-5
Online ISBN: 978-1-4899-7482-2
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