Motor neuron disorders (MNDs) are a heterogeneous group of sporadic and hereditary neurologic diseases causing progressive degeneration of motor neurons. Molecular genetic testing is often essential for diagnosis of MNDs. Autosomal dominant, autosomal recessive, and X-linked inheritance patterns are all found in these disorders. This chapter focuses on hereditary spastic paraplegia, an upper motor neuron disease, Kennedy disease (SBMA), a lower motor neuron disease, and Lou Gehrig disease, amyotrophic lateral sclerosis (ALS) affecting both systems.
- Amyotrophic Lateral Sclerosis
- Motor Neuron
- Spinal Muscular Atrophy
- Motor Neuron Disease
- Lower Motor Neuron
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