Skip to main content

Overview of Cerebrovascular Disease and Stroke Risk Factors

  • Chapter
  • First Online:
Genetic Counseling for Adult Neurogenetic Disease
  • 1354 Accesses

Abstract

Stroke is the fourth leading cause of death in the USA. Many factors can affect an individual’s risk for stroke. Common risk factors for ischemic stroke include age, gender, and ethnicity. Other risk factors for stroke, such as hypertension, high cholesterol, artherosclerosis, and obesity, are influenced by genetics. Genetic syndromes make up about 1 % of this risk. Genetic counseling should include a discussion of manageable environmental risk factors, hereditary factors that can predispose to blood clots, as well as any family history of a Mendelian disorder. This chapter reviews the most common inherited disorders and risk factors.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Alg, V. S., Sofat, R., Houlden, H., & Werring, D. J. (2013). Genetic risk factors for intracranial aneurysms: A meta-analysis in more than 116,000 individuals. Neurology, 80(23), 2154–2165.

    Article  PubMed Central  PubMed  Google Scholar 

  2. Biffi, A., Anderson, C. D., Falcone, G. J., Kissela, B., Norrving, B., Tirschwell, D., et al. (2013). Novel insights into the genetics of intracerebral hemorrhage. Stroke, 44(6 Suppl 1), S137.

    Article  PubMed  Google Scholar 

  3. Gelfand, A. A., Croen, L. A., Torres, A. R., & Wu, Y. W. (2013). Genetic risk factors for perinatal arteriol ischemic stroke. Pediatric Neurology, 48(1), 36–41.

    Article  PubMed Central  PubMed  Google Scholar 

  4. Jerrard-Dunne, P., Evans, A., McGovern, R., Hajat, C., Kalra, L., Rudd, A. G., et al. (2003). Ethnic differences in markers of thrombophilia: Implications for the investigation of ischemic stroke in multiethnic populations: The South London Ethnicity and Stroke Study. Stroke, 34(8), 1821–1826.

    Article  PubMed  Google Scholar 

  5. Touzé, E., & Rothwell, P. M. (2007). Heritability of ischaemic stroke in women compared with men: A genetic epidemiological study. Lancet Neurology, 6(2), 125–133. Erratum in: (2008) Lancet Neurol, 7(1), 25.

    Article  Google Scholar 

  6. J, V. J., & Howard, P. (2013). Reasons underlying racial differences in stroke incidence and mortality. Stroke, 44(6 Suppl 1), S126–S128.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Heather Workman .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer Science+Business Media New York

About this chapter

Cite this chapter

Workman, H. (2015). Overview of Cerebrovascular Disease and Stroke Risk Factors. In: Goldman, J. (eds) Genetic Counseling for Adult Neurogenetic Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7482-2_10

Download citation

Publish with us

Policies and ethics