Abstract
Stroke is the fourth leading cause of death in the USA. Many factors can affect an individual’s risk for stroke. Common risk factors for ischemic stroke include age, gender, and ethnicity. Other risk factors for stroke, such as hypertension, high cholesterol, artherosclerosis, and obesity, are influenced by genetics. Genetic syndromes make up about 1 % of this risk. Genetic counseling should include a discussion of manageable environmental risk factors, hereditary factors that can predispose to blood clots, as well as any family history of a Mendelian disorder. This chapter reviews the most common inherited disorders and risk factors.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Alg, V. S., Sofat, R., Houlden, H., & Werring, D. J. (2013). Genetic risk factors for intracranial aneurysms: A meta-analysis in more than 116,000 individuals. Neurology, 80(23), 2154–2165.
Biffi, A., Anderson, C. D., Falcone, G. J., Kissela, B., Norrving, B., Tirschwell, D., et al. (2013). Novel insights into the genetics of intracerebral hemorrhage. Stroke, 44(6 Suppl 1), S137.
Gelfand, A. A., Croen, L. A., Torres, A. R., & Wu, Y. W. (2013). Genetic risk factors for perinatal arteriol ischemic stroke. Pediatric Neurology, 48(1), 36–41.
Jerrard-Dunne, P., Evans, A., McGovern, R., Hajat, C., Kalra, L., Rudd, A. G., et al. (2003). Ethnic differences in markers of thrombophilia: Implications for the investigation of ischemic stroke in multiethnic populations: The South London Ethnicity and Stroke Study. Stroke, 34(8), 1821–1826.
Touzé, E., & Rothwell, P. M. (2007). Heritability of ischaemic stroke in women compared with men: A genetic epidemiological study. Lancet Neurology, 6(2), 125–133. Erratum in: (2008) Lancet Neurol, 7(1), 25.
J, V. J., & Howard, P. (2013). Reasons underlying racial differences in stroke incidence and mortality. Stroke, 44(6 Suppl 1), S126–S128.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer Science+Business Media New York
About this chapter
Cite this chapter
Workman, H. (2015). Overview of Cerebrovascular Disease and Stroke Risk Factors. In: Goldman, J. (eds) Genetic Counseling for Adult Neurogenetic Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7482-2_10
Download citation
DOI: https://doi.org/10.1007/978-1-4899-7482-2_10
Published:
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-7481-5
Online ISBN: 978-1-4899-7482-2
eBook Packages: Behavioral ScienceBehavioral Science and Psychology (R0)