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Viral Infections of Humans pp 953–970Cite as

Epstein-Barr Virus: Nasopharyngeal Carcinoma and Other Epithelial Tumors

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Abstract

Since its discovery over 45 years ago, Epstein-Barr virus (EBV) has been associated with numerous human carcinomas. Approximately 95 % of the world’s population sustain an asymptomatic lifelong infection with EBV. The virus persists in the memory B cell pool of normal healthy individuals and any disruption of this interaction results in virus-associated B cell tumors. The association of EBV with epithelial cell tumors, specifically nasopharyngeal carcinoma (NPC) and EBV-positive gastric carcinoma (EBV-GC), is less clear and is currently thought to be a consequence of the aberrant establishment of virus latency in epithelial cells displaying premalignant genetic changes. Although the precise role of EBV in the carcinogenic process is currently poorly understood, the presence of the virus in all tumor cells provides opportunities for the development of novel therapeutic and diagnostic approaches. The study of EBV and its role in carcinomas continues to provide insights into the carcinogenic process that are relevant to a broader understanding of tumor pathogenesis and to the development of targeted cancer therapies.

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Acknowledgments

The authors’ studies have been supported by Cancer Research UK, Leukaemia and Lymphoma Research, and the European Commission’s FP6 Life-Sciences-Health Programme (INCA Project: LSHC-CT-2005-018704).

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Authors and Affiliations

  1. Warwick Medical School, The University of Warwick, Coventry, CV4 7AL, UK

    Lawrence S. Young PhD, DSc

  2. School of Cancer Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK

    Christopher W. Dawson PhD & Ciaran B. J. Woodman MD

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  1. Lawrence S. Young PhD, DSc
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  3. Ciaran B. J. Woodman MD
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Correspondence to Lawrence S. Young PhD, DSc .

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Editors and Affiliations

  1. Department of Epidemiology, University of Alabama, Birmingham School of Public Health, Birmingham, Alabama, USA

    Richard A. Kaslow

  2. Departmant of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York, USA

    Lawrence R. Stanberry

  3. Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA

    James W. Le Duc

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Young, L.S., Dawson, C.W., Woodman, C.B.J. (2014). Epstein-Barr Virus: Nasopharyngeal Carcinoma and Other Epithelial Tumors. In: Kaslow, R., Stanberry, L., Le Duc, J. (eds) Viral Infections of Humans. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7448-8_41

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